PH12016501232A1 - Pyrazolo[1,5-a]pyridine derivatives and methods of their use - Google Patents
Pyrazolo[1,5-a]pyridine derivatives and methods of their useInfo
- Publication number
- PH12016501232A1 PH12016501232A1 PH12016501232A PH12016501232A PH12016501232A1 PH 12016501232 A1 PH12016501232 A1 PH 12016501232A1 PH 12016501232 A PH12016501232 A PH 12016501232A PH 12016501232 A PH12016501232 A PH 12016501232A PH 12016501232 A1 PH12016501232 A1 PH 12016501232A1
- Authority
- PH
- Philippines
- Prior art keywords
- pyrazolo
- pyridine derivatives
- methods
- pyridine
- derivatives
- Prior art date
Links
- DVUBDHRTVYLIPA-UHFFFAOYSA-N pyrazolo[1,5-a]pyridine Chemical class C1=CC=CN2N=CC=C21 DVUBDHRTVYLIPA-UHFFFAOYSA-N 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920819P | 2013-12-26 | 2013-12-26 | |
| PCT/US2014/071040 WO2015100117A1 (en) | 2013-12-26 | 2014-12-18 | Pyrazolo[1,5-a]pyridine derivatives and methods of their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12016501232A1 true PH12016501232A1 (en) | 2016-08-15 |
Family
ID=52293273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12016501232A PH12016501232A1 (en) | 2013-12-26 | 2016-06-22 | Pyrazolo[1,5-a]pyridine derivatives and methods of their use |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9914731B2 (OSRAM) |
| EP (2) | EP3309160A1 (OSRAM) |
| JP (1) | JP2017500362A (OSRAM) |
| KR (1) | KR20160110390A (OSRAM) |
| CN (1) | CN106029661B (OSRAM) |
| AU (1) | AU2014370186A1 (OSRAM) |
| BR (1) | BR112016015057A2 (OSRAM) |
| CA (1) | CA2934667A1 (OSRAM) |
| CL (1) | CL2016001604A1 (OSRAM) |
| DK (1) | DK3087070T3 (OSRAM) |
| EA (2) | EA029757B1 (OSRAM) |
| ES (1) | ES2654931T3 (OSRAM) |
| HU (1) | HUE037579T2 (OSRAM) |
| IL (1) | IL246311A0 (OSRAM) |
| MX (1) | MX2016008445A (OSRAM) |
| NO (1) | NO3014707T3 (OSRAM) |
| PH (1) | PH12016501232A1 (OSRAM) |
| PL (1) | PL3087070T3 (OSRAM) |
| PT (1) | PT3087070T (OSRAM) |
| SG (1) | SG11201605207PA (OSRAM) |
| SI (1) | SI3087070T1 (OSRAM) |
| WO (1) | WO2015100117A1 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3322706B1 (en) * | 2015-07-16 | 2020-11-11 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| CN106467541B (zh) * | 2015-08-18 | 2019-04-05 | 暨南大学 | 取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用 |
| CN106543145B (zh) * | 2016-10-28 | 2019-07-19 | 山西医科大学 | c-Met激酶抑剂3-(4-氟苯基)嘧啶酮-5-甲酸酰胺衍生物、制备方法与应用 |
| JP7193460B2 (ja) * | 2016-12-23 | 2022-12-20 | プレキシコン インコーポレーテッド | Ｃｄｋ８調節およびその適応症のための化合物および方法 |
| CN110267960B (zh) | 2017-01-18 | 2022-04-26 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物 |
| WO2019101178A1 (zh) * | 2017-11-24 | 2019-05-31 | 南京明德新药研发股份有限公司 | 作为c-MET/AXL抑制剂的尿嘧啶类化合物 |
| TW201938169A (zh) | 2018-01-18 | 2019-10-01 | 美商亞雷生物製藥股份有限公司 | 作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物 |
| CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
| WO2019143994A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| WO2020038460A1 (zh) * | 2018-08-24 | 2020-02-27 | 南京药捷安康生物科技有限公司 | 一种新型的喹啉衍生物抑制剂 |
| UY38349A (es) | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| ES2922314T3 (es) | 2018-09-10 | 2022-09-13 | Array Biopharma Inc | Compuestos heterocíclicos condensados como inhibidores de cinasa RET |
| KR20210142154A (ko) | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
| CN110467616B (zh) * | 2019-07-01 | 2021-12-21 | 江西科技师范大学 | 含杂芳基取代哒嗪酮结构的三唑并吡嗪类化合物的制备及应用 |
| CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
| US12479850B2 (en) | 2019-09-06 | 2025-11-25 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Compound having Axl and c-Met kinase inhibitory activity, preparation thereof and application thereof |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| PE20230823A1 (es) | 2020-03-30 | 2023-05-19 | Hutchison Medipharma Ltd | Compuestos de amida y usos de los mismos |
| JPWO2023286719A1 (OSRAM) * | 2021-07-13 | 2023-01-19 | ||
| IT202100022682A1 (it) * | 2021-09-01 | 2023-03-01 | Luigi Frati | Derivati pirimidinici e loro uso nel trattamento di tumori |
| CN116655626B (zh) * | 2023-05-24 | 2025-03-11 | 遵义医科大学 | 一种含咪唑并[l，2-a]吡啶骨架的环丙二酰胺化合物及其制备方法和用途 |
| WO2025034912A2 (en) | 2023-08-07 | 2025-02-13 | Cogent Biosciences, Inc. | Compounds for fgfr inhibition |
| WO2025111224A1 (en) * | 2023-11-21 | 2025-05-30 | Fmc Corporation | Linked bicyclic compounds for controlling and combating invertebrate pests |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7547782B2 (en) * | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| JP2009529047A (ja) * | 2006-03-07 | 2009-08-13 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環系ピラゾール化合物およびその使用 |
| JPWO2008072634A1 (ja) * | 2006-12-12 | 2010-04-02 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| EP1972628A1 (en) | 2007-03-21 | 2008-09-24 | Schwarz Pharma Ag | Indolizines and aza-analog derivatives thereof as CNS active compounds |
| US8455477B2 (en) | 2008-08-05 | 2013-06-04 | Merck Sharp & Dohme Corp. | Therapeutic compounds |
| ES2840454T3 (es) * | 2009-12-31 | 2021-07-06 | Hutchison Medipharma Ltd | Intermedio sintético útil en la preparación de inhibidores de c-Met triazolopiridínicos |
| JP5959541B2 (ja) * | 2011-02-25 | 2016-08-02 | ノバルティス アーゲー | Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン |
| CN102827186A (zh) * | 2011-06-16 | 2012-12-19 | 中国科学院上海药物研究所 | 一类吡啶并五元杂环衍生物及其制备方法和用途 |
| CA2844588A1 (en) * | 2011-08-10 | 2013-02-14 | Merck Patent Gmbh | Pyrido-pyrimidine derivatives |
| KR20140064971A (ko) * | 2011-09-19 | 2014-05-28 | 제넨테크, 인크. | c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료 |
| DK2780338T3 (en) * | 2011-11-14 | 2016-12-19 | Ignyta Inc | Uracil AS AXL- AND C-MET kinase inhibitors |
| WO2013180949A1 (en) * | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
-
2014
- 2014-12-18 DK DK14824711.7T patent/DK3087070T3/en active
- 2014-12-18 PT PT148247117T patent/PT3087070T/pt unknown
- 2014-12-18 EA EA201691164A patent/EA029757B1/ru not_active IP Right Cessation
- 2014-12-18 EP EP17196014.9A patent/EP3309160A1/en not_active Withdrawn
- 2014-12-18 CN CN201480075903.4A patent/CN106029661B/zh not_active Expired - Fee Related
- 2014-12-18 BR BR112016015057A patent/BR112016015057A2/pt not_active IP Right Cessation
- 2014-12-18 EP EP14824711.7A patent/EP3087070B1/en not_active Not-in-force
- 2014-12-18 MX MX2016008445A patent/MX2016008445A/es unknown
- 2014-12-18 US US15/108,400 patent/US9914731B2/en not_active Expired - Fee Related
- 2014-12-18 WO PCT/US2014/071040 patent/WO2015100117A1/en not_active Ceased
- 2014-12-18 SG SG11201605207PA patent/SG11201605207PA/en unknown
- 2014-12-18 ES ES14824711.7T patent/ES2654931T3/es active Active
- 2014-12-18 AU AU2014370186A patent/AU2014370186A1/en not_active Abandoned
- 2014-12-18 SI SI201430533T patent/SI3087070T1/en unknown
- 2014-12-18 PL PL14824711T patent/PL3087070T3/pl unknown
- 2014-12-18 EA EA201890061A patent/EA201890061A3/ru unknown
- 2014-12-18 KR KR1020167019605A patent/KR20160110390A/ko not_active Withdrawn
- 2014-12-18 HU HUE14824711A patent/HUE037579T2/hu unknown
- 2014-12-18 JP JP2016542956A patent/JP2017500362A/ja active Pending
- 2014-12-18 CA CA2934667A patent/CA2934667A1/en not_active Abandoned
-
2015
- 2015-06-23 NO NO15745380A patent/NO3014707T3/no unknown
-
2016
- 2016-06-19 IL IL246311A patent/IL246311A0/en unknown
- 2016-06-21 CL CL2016001604A patent/CL2016001604A1/es unknown
- 2016-06-22 PH PH12016501232A patent/PH12016501232A1/en unknown
-
2018
- 2018-01-24 US US15/879,175 patent/US20180148447A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SI3087070T1 (en) | 2018-01-31 |
| EP3087070A1 (en) | 2016-11-02 |
| PT3087070T (pt) | 2018-01-30 |
| CA2934667A1 (en) | 2015-07-02 |
| EP3087070B1 (en) | 2017-11-08 |
| JP2017500362A (ja) | 2017-01-05 |
| PL3087070T3 (pl) | 2018-03-30 |
| KR20160110390A (ko) | 2016-09-21 |
| MX2016008445A (es) | 2016-10-28 |
| EP3309160A1 (en) | 2018-04-18 |
| CN106029661B (zh) | 2017-11-03 |
| EA201691164A1 (ru) | 2016-12-30 |
| HUE037579T2 (hu) | 2018-09-28 |
| DK3087070T3 (en) | 2017-12-04 |
| BR112016015057A2 (pt) | 2017-08-08 |
| AU2014370186A2 (en) | 2016-07-21 |
| US20180148447A1 (en) | 2018-05-31 |
| EA201890061A3 (ru) | 2018-09-28 |
| SG11201605207PA (en) | 2016-07-28 |
| AU2014370186A1 (en) | 2016-07-14 |
| ES2654931T3 (es) | 2018-02-15 |
| CN106029661A (zh) | 2016-10-12 |
| NO3014707T3 (OSRAM) | 2018-01-06 |
| WO2015100117A1 (en) | 2015-07-02 |
| US9914731B2 (en) | 2018-03-13 |
| US20160318929A1 (en) | 2016-11-03 |
| EA201890061A2 (ru) | 2018-05-31 |
| CL2016001604A1 (es) | 2017-05-26 |
| EA029757B1 (ru) | 2018-05-31 |
| IL246311A0 (en) | 2016-08-02 |
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