PH12014502410A1 - Breast cancer prognosis, prediction of progesterone receptor subtype and|prediction of response to antiprogestin treatment based on gene expression - Google Patents
Breast cancer prognosis, prediction of progesterone receptor subtype and|prediction of response to antiprogestin treatment based on gene expressionInfo
- Publication number
- PH12014502410A1 PH12014502410A1 PH12014502410A PH12014502410A PH12014502410A1 PH 12014502410 A1 PH12014502410 A1 PH 12014502410A1 PH 12014502410 A PH12014502410 A PH 12014502410A PH 12014502410 A PH12014502410 A PH 12014502410A PH 12014502410 A1 PH12014502410 A1 PH 12014502410A1
- Authority
- PH
- Philippines
- Prior art keywords
- prediction
- gene expression
- progesterone receptor
- response
- breast cancer
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 5
- 230000000708 anti-progestin effect Effects 0.000 title abstract 2
- 239000003418 antiprogestin Substances 0.000 title abstract 2
- 102000003998 progesterone receptors Human genes 0.000 title abstract 2
- 108090000468 progesterone receptors Proteins 0.000 title abstract 2
- 206010006187 Breast cancer Diseases 0.000 title 1
- 208000026310 Breast neoplasm Diseases 0.000 title 1
- 238000004393 prognosis Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101150010487 are gene Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261639407P | 2012-04-27 | 2012-04-27 | |
| PCT/US2013/032677 WO2013162776A1 (en) | 2012-04-27 | 2013-03-15 | Breast cancer prognosis, prediction of progesterone receptor subtype and|prediction of response to antiprogestin treatment based on gene expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12014502410A1 true PH12014502410A1 (en) | 2015-01-12 |
Family
ID=48045769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12014502410A PH12014502410A1 (en) | 2012-04-27 | 2014-10-27 | Breast cancer prognosis, prediction of progesterone receptor subtype and|prediction of response to antiprogestin treatment based on gene expression |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10501800B2 (https=) |
| EP (1) | EP2841594A1 (https=) |
| JP (1) | JP2015516155A (https=) |
| KR (1) | KR20150028232A (https=) |
| AU (1) | AU2013252913A1 (https=) |
| CA (1) | CA2871590A1 (https=) |
| HK (1) | HK1208057A1 (https=) |
| IL (1) | IL235351A0 (https=) |
| MX (1) | MX2014013044A (https=) |
| NZ (1) | NZ701652A (https=) |
| PH (1) | PH12014502410A1 (https=) |
| RU (1) | RU2014147625A (https=) |
| WO (1) | WO2013162776A1 (https=) |
| ZA (1) | ZA201407853B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2014013044A (es) | 2012-04-27 | 2015-06-23 | Univ Minnesota | Pronostico de cancer de mamas, prediccion de subtipo de receptor de progesterona y prediccion de respuesta a tratamiento de antiprogestina basado en la expresion de genes. |
| US20140363425A1 (en) * | 2013-03-13 | 2014-12-11 | J. Dinny Graham | Systems and methods for identifying cancers having activated progesterone receptors |
| US20150276767A1 (en) * | 2014-03-12 | 2015-10-01 | The University Of Sydney | Systems and methods for identifying cancers having activated progesterone receptors |
| CN113559075A (zh) | 2014-11-17 | 2021-10-29 | 康泰科思特生物制药公司 | 奥那司酮延长释放组合物和方法 |
| AU2016326657B2 (en) | 2015-09-25 | 2019-10-24 | Context Biopharma, Inc. | Methods of making onapristone intermediates |
| EP3389632A4 (en) | 2015-12-15 | 2019-11-06 | Context Biopharma Inc. | AMORPHIC ONAPRISTON COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF |
| WO2018102369A1 (en) | 2016-11-30 | 2018-06-07 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
| US10942183B2 (en) | 2017-04-05 | 2021-03-09 | Regents Of The University Of Minnesota | Methods of detecting progesterone receptor and of detecting an expression level |
| EP3822368A1 (en) | 2019-11-14 | 2021-05-19 | Koninklijke Philips N.V. | Assessment of pr cellular signaling pathway activity using mathematical modelling of target gene expression |
| EP4121964A1 (en) * | 2020-03-17 | 2023-01-25 | Regeneron Pharmaceuticals, Inc. | Methods and systems for determining responders to treatment |
| JP7619556B2 (ja) * | 2020-10-08 | 2025-01-22 | 藤倉化成株式会社 | 動脈病変を検出し、並びに、脳心臓血管障害、糖尿病、慢性腎臓病、又は固形癌を検出する、体液抗体バイオマーカー |
| US20250005743A1 (en) * | 2023-06-30 | 2025-01-02 | Mackay Memorial Hospital | Method and system for identifying hormone receptor status |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6750015B2 (en) * | 2000-06-28 | 2004-06-15 | Kathryn B. Horwitz | Progesterone receptor-regulated gene expression and methods related thereto |
| AU2001271579A1 (en) | 2000-06-28 | 2002-01-08 | University Technology Corporation | Progesterone receptor-regulated gene expression and methods related thereto |
| MX2014013044A (es) | 2012-04-27 | 2015-06-23 | Univ Minnesota | Pronostico de cancer de mamas, prediccion de subtipo de receptor de progesterona y prediccion de respuesta a tratamiento de antiprogestina basado en la expresion de genes. |
-
2013
- 2013-03-15 MX MX2014013044A patent/MX2014013044A/es unknown
- 2013-03-15 KR KR20147033298A patent/KR20150028232A/ko not_active Withdrawn
- 2013-03-15 HK HK15108666.9A patent/HK1208057A1/xx unknown
- 2013-03-15 US US13/843,482 patent/US10501800B2/en active Active
- 2013-03-15 WO PCT/US2013/032677 patent/WO2013162776A1/en not_active Ceased
- 2013-03-15 EP EP13714144.6A patent/EP2841594A1/en not_active Withdrawn
- 2013-03-15 AU AU2013252913A patent/AU2013252913A1/en not_active Abandoned
- 2013-03-15 CA CA2871590A patent/CA2871590A1/en not_active Abandoned
- 2013-03-15 RU RU2014147625A patent/RU2014147625A/ru not_active Application Discontinuation
- 2013-03-15 NZ NZ701652A patent/NZ701652A/en not_active IP Right Cessation
- 2013-03-15 JP JP2015508975A patent/JP2015516155A/ja active Pending
-
2014
- 2014-10-27 IL IL235351A patent/IL235351A0/en unknown
- 2014-10-27 PH PH12014502410A patent/PH12014502410A1/en unknown
- 2014-10-28 ZA ZA2014/07853A patent/ZA201407853B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013252913A1 (en) | 2014-11-27 |
| WO2013162776A1 (en) | 2013-10-31 |
| US20130316992A1 (en) | 2013-11-28 |
| IL235351A0 (en) | 2014-12-31 |
| EP2841594A1 (en) | 2015-03-04 |
| ZA201407853B (en) | 2015-12-23 |
| US10501800B2 (en) | 2019-12-10 |
| KR20150028232A (ko) | 2015-03-13 |
| RU2014147625A (ru) | 2016-06-20 |
| CA2871590A1 (en) | 2013-10-31 |
| HK1208057A1 (en) | 2016-02-19 |
| JP2015516155A (ja) | 2015-06-11 |
| MX2014013044A (es) | 2015-06-23 |
| NZ701652A (en) | 2016-09-30 |
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