PH12014501815B1 - Purinone compounds as kinase inhibitors - Google Patents

Purinone compounds as kinase inhibitors Download PDF

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Publication number
PH12014501815B1
PH12014501815B1 PH12014501815A PH12014501815A PH12014501815B1 PH 12014501815 B1 PH12014501815 B1 PH 12014501815B1 PH 12014501815 A PH12014501815 A PH 12014501815A PH 12014501815 A PH12014501815 A PH 12014501815A PH 12014501815 B1 PH12014501815 B1 PH 12014501815B1
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Philippines
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substituted
unsubstituted
compound
formula
cycloalkyl
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PH12014501815A
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PH12014501815A1 (en
Inventor
Wei Chen
David J Loury
Shunqi Yan
Longcheng Wang
Leah Lynn Frye
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Pharmacyclics Inc
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Publication of PH12014501815A1 publication Critical patent/PH12014501815A1/en
Publication of PH12014501815B1 publication Critical patent/PH12014501815B1/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
PH12014501815A 2012-01-31 2014-07-31 Purinone compounds as kinase inhibitors PH12014501815B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261593146P 2012-01-31 2012-01-31
US201261637765P 2012-04-24 2012-04-24
US13/460,524 US8501724B1 (en) 2012-01-31 2012-04-30 Purinone compounds as kinase inhibitors
PCT/US2013/023918 WO2013116382A1 (en) 2012-01-31 2013-01-30 Purinone compounds as kinase inhibitors

Publications (2)

Publication Number Publication Date
PH12014501815A1 PH12014501815A1 (en) 2014-11-17
PH12014501815B1 true PH12014501815B1 (en) 2014-11-17

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ID=48870746

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Application Number Title Priority Date Filing Date
PH12014501815A PH12014501815B1 (en) 2012-01-31 2014-07-31 Purinone compounds as kinase inhibitors

Country Status (14)

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US (3) US8501724B1 (https=)
EP (2) EP2809672A4 (https=)
JP (3) JP6095075B2 (https=)
KR (2) KR101841325B1 (https=)
CN (2) CN106279172A (https=)
AU (3) AU2013215166B2 (https=)
BR (1) BR112014018728A8 (https=)
CA (2) CA2940039A1 (https=)
HK (1) HK1203489A1 (https=)
IL (1) IL261282A (https=)
MX (1) MX2014009219A (https=)
PH (1) PH12014501815B1 (https=)
RU (2) RU2018118216A (https=)
WO (1) WO2013116382A1 (https=)

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