PH12013501321A1 - Phenoxymethyl heterocyclic compounds - Google Patents

Phenoxymethyl heterocyclic compounds

Info

Publication number
PH12013501321A1
PH12013501321A1 PH12013501321A PH12013501321A PH12013501321A1 PH 12013501321 A1 PH12013501321 A1 PH 12013501321A1 PH 12013501321 A PH12013501321 A PH 12013501321A PH 12013501321 A PH12013501321 A PH 12013501321A PH 12013501321 A1 PH12013501321 A1 PH 12013501321A1
Authority
PH
Philippines
Prior art keywords
heterocyclic compounds
compounds
phenoxymethyl
phenoxymethyl heterocyclic
phosphodiesterase
Prior art date
Application number
PH12013501321A
Other languages
English (en)
Other versions
PH12013501321B1 (en
Inventor
Gideon Shapiro
Amy Ripka
Richard Chesworth
Original Assignee
Envivo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Envivo Pharmaceuticals Inc filed Critical Envivo Pharmaceuticals Inc
Publication of PH12013501321B1 publication Critical patent/PH12013501321B1/en
Publication of PH12013501321A1 publication Critical patent/PH12013501321A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH12013501321A 2009-05-07 2013-06-20 Phenoxymethyl heterocyclic compounds PH12013501321A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17641309P 2009-05-07 2009-05-07
PCT/US2009/068644 WO2010128995A1 (en) 2009-05-07 2009-12-18 Phenoxymethyl heterocyclic compounds

Publications (2)

Publication Number Publication Date
PH12013501321B1 PH12013501321B1 (en) 2014-08-27
PH12013501321A1 true PH12013501321A1 (en) 2014-08-27

Family

ID=41549054

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12013501321A PH12013501321A1 (en) 2009-05-07 2013-06-20 Phenoxymethyl heterocyclic compounds

Country Status (32)

Country Link
US (3) US8343973B2 (en, 2012)
EP (3) EP2617420B1 (en, 2012)
JP (2) JP5628902B2 (en, 2012)
KR (1) KR101662699B1 (en, 2012)
CN (2) CN102459242B (en, 2012)
AU (1) AU2009345802B2 (en, 2012)
BR (1) BRPI0924617A8 (en, 2012)
CA (1) CA2761032A1 (en, 2012)
CL (1) CL2011002792A1 (en, 2012)
CO (1) CO6460744A2 (en, 2012)
CR (1) CR20110648A (en, 2012)
DK (2) DK2617420T3 (en, 2012)
EC (1) ECSP11011479A (en, 2012)
ES (2) ES2554788T3 (en, 2012)
HR (2) HRP20130482T1 (en, 2012)
HU (1) HUE026238T2 (en, 2012)
IL (2) IL216149A (en, 2012)
ME (1) ME02375B (en, 2012)
MX (1) MX2011011755A (en, 2012)
MY (1) MY183910A (en, 2012)
NZ (1) NZ596753A (en, 2012)
PE (1) PE20120900A1 (en, 2012)
PH (1) PH12013501321A1 (en, 2012)
PL (2) PL2427454T3 (en, 2012)
PT (2) PT2617420E (en, 2012)
RS (2) RS54529B1 (en, 2012)
RU (1) RU2531274C2 (en, 2012)
SG (1) SG175900A1 (en, 2012)
SI (2) SI2617420T1 (en, 2012)
SM (2) SMT201300070B (en, 2012)
WO (1) WO2010128995A1 (en, 2012)
ZA (1) ZA201108920B (en, 2012)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071595B2 (en) 2008-06-25 2011-12-06 Envivo Pharmaceuticals, Inc. 1,2-disubstituted heterocyclic compounds
RS54529B1 (en) 2009-05-07 2016-06-30 Forum Pharmaceuticals Inc. PHENOXIMETHYL HETEROCYCLIC COMPOUNDS
KR20140009372A (ko) 2011-02-18 2014-01-22 알러간, 인코포레이티드 포스포다이에스테라제 10(pde10a)의 억제제로서의 치환된 6,7-다이알콕시-3-아이소퀴놀리놀 유도체
RU2632915C2 (ru) 2012-06-12 2017-10-11 Эббви Инк. Производные пиридинона и пиридазинона
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
ES2480341B1 (es) 2013-01-24 2015-01-22 Palobiofarma S.L Nuevos derivados de pirimidina como inhibidores de la fosfodiesterasa 10 (PDE-10)
TW201512201A (zh) * 2013-03-14 2015-04-01 Forum Pharmaceuticals Inc 化合物的多晶型及鹽類
TWI634114B (zh) * 2013-05-08 2018-09-01 永恒生物科技公司 作為激酶抑制劑之呋喃酮化合物
WO2015006689A1 (en) 2013-07-12 2015-01-15 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60026348T2 (de) * 1999-11-05 2006-10-19 Societe De Conseils De Recherches Et D`Applications Scientifiques (S.C.R.A.S.) Heterocyclische verbindungen und ihre verwendung als medikamente
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
JPWO2004002484A1 (ja) 2002-06-26 2005-10-27 協和醗酵工業株式会社 ホスホジエステラーゼ阻害剤
JP4302762B2 (ja) * 2005-01-07 2009-07-29 ファイザー・プロダクツ・インク 複素環式芳香族キノリン化合物およびｐｄｅ１０阻害剤としてのその使用
NL2000397C2 (nl) * 2006-01-05 2007-10-30 Pfizer Prod Inc Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
JP2009535394A (ja) 2006-05-02 2009-10-01 ファイザー・プロダクツ・インク Ｐｄｅ１０阻害剤としての二環式ヘテロアリール化合物
WO2008033455A2 (en) 2006-09-13 2008-03-20 The Institutes For Pharmaceutical Discovery, Llc Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors
FR2928924B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
US8071595B2 (en) * 2008-06-25 2011-12-06 Envivo Pharmaceuticals, Inc. 1,2-disubstituted heterocyclic compounds
RS54529B1 (en) 2009-05-07 2016-06-30 Forum Pharmaceuticals Inc. PHENOXIMETHYL HETEROCYCLIC COMPOUNDS
MX2012002596A (es) * 2009-09-03 2012-07-03 Allergan Inc Compuestos como moduladores de tirosina cinasas.
RU2016124136A (ru) * 2010-08-18 2018-12-03 СЭМЬЮМЕД, ЭлЭлСи Дикетоны и гидроксикетоны в качестве активатора сигнального пути катенина

Also Published As

Publication number Publication date
RS52838B (en) 2013-10-31
CA2761032A1 (en) 2010-11-11
US20130143888A1 (en) 2013-06-06
EP2427454B1 (en) 2013-03-20
CN105125547A (zh) 2015-12-09
EP2427454A1 (en) 2012-03-14
RU2531274C2 (ru) 2014-10-20
CO6460744A2 (es) 2012-06-15
AU2009345802A1 (en) 2011-12-15
CN102459242A (zh) 2012-05-16
PT2617420E (pt) 2015-12-18
SMT201300070B (it) 2013-09-06
SMT201600031B (it) 2016-02-25
ZA201108920B (en) 2012-08-29
RU2011149637A (ru) 2013-06-20
SI2427454T1 (sl) 2013-08-30
DK2427454T3 (da) 2013-06-17
NZ596753A (en) 2013-09-27
PL2427454T3 (pl) 2013-09-30
EP2617420B1 (en) 2015-09-23
EP2617420A1 (en) 2013-07-24
HK1186981A1 (en) 2014-03-28
RS54529B1 (en) 2016-06-30
ES2409404T3 (es) 2013-06-26
PH12013501321B1 (en) 2014-08-27
DK2617420T3 (da) 2015-12-07
MY183910A (en) 2021-03-17
IL216149A (en) 2016-02-29
HUE026238T2 (en) 2016-06-28
AU2009345802B2 (en) 2016-05-26
US8343973B2 (en) 2013-01-01
PE20120900A1 (es) 2012-08-14
BRPI0924617A8 (pt) 2017-10-03
MX2011011755A (es) 2012-03-16
IL244059A0 (en) 2016-04-21
JP2015038112A (ja) 2015-02-26
EP3020716A1 (en) 2016-05-18
ECSP11011479A (es) 2011-12-30
ES2554788T3 (es) 2015-12-23
PT2427454E (pt) 2013-06-20
KR101662699B1 (ko) 2016-10-05
JP5943053B2 (ja) 2016-06-29
WO2010128995A1 (en) 2010-11-11
HK1167402A1 (en) 2012-11-30
US20100292238A1 (en) 2010-11-18
CR20110648A (es) 2012-03-28
SI2617420T1 (sl) 2016-02-29
JP2012526107A (ja) 2012-10-25
HRP20151273T1 (hr) 2016-01-29
KR20120027268A (ko) 2012-03-21
CL2011002792A1 (es) 2012-06-01
SG175900A1 (en) 2011-12-29
JP5628902B2 (ja) 2014-11-19
IL216149A0 (en) 2012-01-31
US20150322069A1 (en) 2015-11-12
PL2617420T3 (pl) 2016-04-29
BRPI0924617A2 (en, 2012) 2017-07-11
CN102459242B (zh) 2015-08-26
ME02375B (me) 2016-06-20
US8946222B2 (en) 2015-02-03
HRP20130482T1 (en) 2013-08-31

Similar Documents

Publication Publication Date Title
PH12013501321B1 (en) Phenoxymethyl heterocyclic compounds
TN2014000016A1 (en) 4 - piperidinyl compounds for use as tankyrase inhibitors
NZ705135A (en) Heteroaryl compounds and methods of use thereof
IL243574B (en) A pharmaceutical preparation for use in the treatment of a disease treatable by blocking purine receptors
UA113051C2 (xx) Гетероциклічні похідні та їх застосування у лікуванні неврологічних розладів
NZ708864A (en) Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors
GEP20146146B (en) Pyrrolopyrimidine compounds as inhibitors of cdk4/6
MX2011011854A (es) Dihidropirimidinonas para uso como inhibidores de la bace2.
SG179034A1 (en) 2 -aminodihydro [1, 3] thiazines as bace 2 inhibitors for the treatment of diabetes
PH12014501514A1 (en) New azetidine derivatives, pharmaceutical compositions and uses thereof
CR20200286A (es) DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294)
GB2511685A (en) Muscarinic m1 receptor agonists
PH12014501967B1 (en) Benzodioxanes in combination with other actives for inhibiting leukotriene production
GEP20166483B (en) Phenyl-3-aza-bicyclo[3.1.0] hex-3-yl-methanones and the use thereof as medicament
MX2014004858A (es) Compuestos de 3,4-diamino-3-ciclobuten-1,2-diona disustituidos utiles en el tratamiento de patologias mediadas por quimiocinas.
MX2014000964A (es) Derivados aza heterociclicos sustituidos.
MX342924B (es) Nuevos compuestos disustituidos de 3,4-diamino-3-ciclobuteno-1,2-d iona para uso en el tratamiento de patologias mediadas por quimiocinas.
MX2010009462A (es) Derivados de indazol.
PH12013500644A1 (en) Co-crystals and salts of ccr3-inhibitors
GEP20135806B (en) Lactams as beta secretase inhibitors
MX360330B (es) Regimen de administracion para nitrocatecoles.
MY178583A (en) Hydantoin derivative
MY152040A (en) Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments
MY148732A (en) Triazolium salts as par1 inhibitors, production thereof, and use as medicaments
NZ702239A (en) Heteroaryl compounds and methods of use thereof