PH12013500934A1 - Crystalline solids of a metap-2 inhibitor and methods of making and using same - Google Patents
Crystalline solids of a metap-2 inhibitor and methods of making and using sameInfo
- Publication number
- PH12013500934A1 PH12013500934A1 PH1/2013/500934A PH12013500934A PH12013500934A1 PH 12013500934 A1 PH12013500934 A1 PH 12013500934A1 PH 12013500934 A PH12013500934 A PH 12013500934A PH 12013500934 A1 PH12013500934 A1 PH 12013500934A1
- Authority
- PH
- Philippines
- Prior art keywords
- metap
- inhibitor
- making
- methods
- same
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- CEVCTNCUIVEQOY-UHFFFAOYSA-N Fumagillol Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(O)CCC21CO2 CEVCTNCUIVEQOY-UHFFFAOYSA-N 0.000 abstract 1
- CEVCTNCUIVEQOY-STXHBLNNSA-N fumagillol Chemical compound C([C@@H](O)[C@H](C1[C@]2(C)[C@H](O2)CC=C(C)C)OC)C[C@@]21CO2 CEVCTNCUIVEQOY-STXHBLNNSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/32—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41165510P | 2010-11-09 | 2010-11-09 | |
| PCT/US2011/059966 WO2012064838A1 (en) | 2010-11-09 | 2011-11-09 | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12013500934A1 true PH12013500934A1 (en) | 2022-10-24 |
Family
ID=45048246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2013/500934A PH12013500934A1 (en) | 2010-11-09 | 2010-11-09 | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US8349891B2 (enExample) |
| EP (1) | EP2638023B1 (enExample) |
| JP (1) | JP6239977B2 (enExample) |
| KR (1) | KR101892768B1 (enExample) |
| CN (2) | CN103347870A (enExample) |
| AU (1) | AU2011326566B2 (enExample) |
| BR (1) | BR112013011550A2 (enExample) |
| CA (1) | CA2817199C (enExample) |
| EA (1) | EA029941B1 (enExample) |
| ES (1) | ES2610216T3 (enExample) |
| IL (1) | IL226238B (enExample) |
| MX (1) | MX2013005208A (enExample) |
| MY (1) | MY177039A (enExample) |
| NZ (1) | NZ610569A (enExample) |
| PH (1) | PH12013500934A1 (enExample) |
| SG (1) | SG190688A1 (enExample) |
| UA (1) | UA111479C2 (enExample) |
| WO (1) | WO2012064838A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010009374A1 (en) * | 2008-07-18 | 2010-01-21 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| MX337575B (es) | 2009-10-09 | 2016-03-10 | Zafgen Corp | Compuestos de sulfona y métodos para lafabricación y uso de éstos. |
| WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
| US8772333B2 (en) | 2010-01-08 | 2014-07-08 | Zafgen, Inc. | Fumigillol type compounds and methods of making and using same |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| EP2576638B1 (en) | 2010-05-25 | 2020-12-23 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| WO2012012642A1 (en) | 2010-07-22 | 2012-01-26 | Zafgen Corporation | Tricyclic compounds and methds of making and using same |
| PH12013500934A1 (en) | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| BR112013013411A2 (pt) | 2010-11-29 | 2016-09-13 | Zafgen Inc | tratamento de obesidade usando administração não diária de 6-0-(4-dimetilaminoetxi) cinamoil fumagilol |
| CN103402989B (zh) | 2011-01-26 | 2016-04-06 | 扎夫根股份有限公司 | 四唑化合物及其制备和使用方法 |
| BR112013028665A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
| WO2012154676A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen Corporation | Partially saturated tricyclic compounds and methods of making and using same |
| KR20140040739A (ko) | 2011-05-06 | 2014-04-03 | 자프겐 인크. | 삼환식 피라졸 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법 |
| EP2763671A2 (en) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
| MX2014008706A (es) | 2012-01-18 | 2015-03-05 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos. |
| BR112014017780A8 (pt) | 2012-01-18 | 2017-07-11 | Zafgen Inc | Compostos de sulfona tricíclicos e métodos para fazer e usar os mesmos |
| KR20150016303A (ko) | 2012-05-07 | 2015-02-11 | 자프겐 인크. | 6-o-(4-디메틸아미노에톡시) 신나모일 푸마지롤의 옥살레이트 염의 다형체 염 및 이의 제조 및 사용 방법 |
| EP2846792B1 (en) | 2012-05-08 | 2018-08-15 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
| JP6177888B2 (ja) | 2012-05-09 | 2017-08-09 | ザフゲン，インコーポレイテッド | フマギロール型化合物ならびにその製造および使用方法 |
| WO2014071363A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| US9868717B2 (en) | 2012-11-05 | 2018-01-16 | Zafgen, Inc. | Tricyclic sulphonamide compounds and methods of making and using same |
| JP6169716B2 (ja) | 2012-11-05 | 2017-07-26 | ザフゲン，インコーポレイテッド | 肝疾患を治療する方法 |
| US20150361139A1 (en) * | 2013-01-30 | 2015-12-17 | Sandoz Ag | Crystalline form of linaclotide |
| EP3431475B1 (en) * | 2013-02-21 | 2021-04-07 | Pfizer Inc | Solid forms of a selective cdk4/6 inhibitor |
| US9597309B2 (en) | 2013-03-14 | 2017-03-21 | Zafgen, Inc. | Methods of treating renal disease and other disorders |
| BR112015025892A2 (pt) | 2013-04-10 | 2017-07-25 | Syndevrx Inc | inibidores de metap2 e métodos para tratar obesidade |
| AR101608A1 (es) * | 2014-08-22 | 2016-12-28 | Zafgen Inc | Formulaciones que contienen un inhibidor de metap-2 |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| DK3386956T3 (da) | 2015-12-10 | 2021-10-11 | Syndevrx Inc | Fumagillolderivater og polymorfer deraf |
| CA3239447A1 (en) * | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| CA3117666A1 (en) | 2018-10-26 | 2020-04-30 | Syndevrx, Inc. | Biomarkers of metap2 inhibitors and applications thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164410A (en) | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| PH26256A (en) | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
| KR0138530B1 (ko) | 1988-09-01 | 1998-05-15 | 우메모또 요시마사 | 푸마길롤 유도체 |
| US5166172A (en) | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5180738A (en) | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
| DE69001187T2 (de) | 1989-03-06 | 1993-07-08 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
| US5288722A (en) | 1989-03-06 | 1994-02-22 | Takeda Chemical Industries, Ltd. | 6-amino-6-desoxyfumagillols, production and use thereof |
| US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US6017954A (en) | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
| EP0415294A3 (en) | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| TW282399B (enExample) | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| DE69330690T2 (de) | 1992-01-30 | 2002-06-20 | Takeda Chemical Industries, Ltd. | Verfahren zur Herstellung hoch-wasserlöslicher Zyklodextrinkomplexe |
| DE69311278T2 (de) | 1992-12-16 | 1997-10-30 | Takeda Chemical Industries Ltd | Stabile pharmazeutische Zubereitung mit Fumagillolderivaten |
| HU224028B1 (hu) | 1995-03-27 | 2005-05-30 | Assistance Publique-Hopitaux De Paris | Fumagillol és származékai alkalmazása bélfertőzések kezelésére szolgáló gyógyszerek előállítására |
| WO1997013509A1 (en) | 1995-10-11 | 1997-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Vascular permeation inhibitor |
| EP0799616A1 (en) | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| WO1998005293A2 (en) | 1996-08-02 | 1998-02-12 | The Children's Medical Center Corporation | Method of regulating the female reproductive system through angiogenesis inhibitors |
| US6207704B1 (en) | 1997-06-09 | 2001-03-27 | Massachusetts Institute Of Technology | Type 2 methionine aminopeptidase [MetAP2] inhibitors and uses thereof |
| JP2002502814A (ja) | 1997-10-31 | 2002-01-29 | チルドレンズ・メディカル・センター・コーポレイション | 血管化した正常組織の大きさおよび増殖の調節のための方法 |
| KR100357541B1 (ko) | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
| KR100357542B1 (ko) | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
| JP2000116337A (ja) | 1998-10-09 | 2000-04-25 | Nippon Shokuhin Kako Co Ltd | ペットフード |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| EE200100558A (et) | 1999-04-28 | 2002-12-16 | Aventis Pharma Deutschland Gmbh | Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine |
| US6323228B1 (en) | 2000-09-15 | 2001-11-27 | Abbott Laboratories | 3-substituted indole angiogenesis inhibitors |
| AU2002239479B2 (en) | 2000-11-01 | 2006-11-09 | Praecis Pharmaceuticals Incorporated | Peptides as Met-AP2 inhibitors |
| US6548477B1 (en) | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| DE60233420D1 (de) | 2001-09-27 | 2009-10-01 | Equispharm Co Ltd | Fumagillolderivate und verfahren zu deren herstellung |
| US6803382B2 (en) | 2001-11-09 | 2004-10-12 | Galderma Research & Development, S.N.C. | Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof |
| KR100451485B1 (ko) | 2002-03-28 | 2004-10-06 | 주식회사종근당 | 푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물 |
| US20040067266A1 (en) | 2002-10-07 | 2004-04-08 | Toppo Frank R. | Weight loss compound |
| US20040157836A1 (en) | 2002-10-08 | 2004-08-12 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
| WO2004078113A2 (en) | 2003-03-04 | 2004-09-16 | Pharmacia Corporation | Treatment and prevention of obesity with cox-2 inhibitors alone or in combination with weight-loss agents |
| US20050239878A1 (en) | 2003-12-29 | 2005-10-27 | Praecis Pharmaceuticals, Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
| KR100552043B1 (ko) * | 2004-02-28 | 2006-02-20 | 주식회사종근당 | 푸마질롤 유도체를 포함하는 비만치료용 조성물 |
| US20060045865A1 (en) | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
| JP2008528574A (ja) | 2005-01-26 | 2008-07-31 | チョン クン ダン ファーマシューティカル コープ． | フマギロール誘導体またはフマギロール誘導体の製造方法およびこれを含む医薬用組成物 |
| FR2886855B1 (fr) | 2005-06-08 | 2009-07-17 | Agronomique Inst Nat Rech | Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques |
| WO2006138475A2 (en) | 2005-06-16 | 2006-12-28 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| BRPI0820229A2 (pt) | 2007-11-28 | 2017-05-09 | A Stevenson Cheri | conjugados de análogos de fumagilina biodegradáveis biocompatíveis |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| WO2010065883A2 (en) * | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| US20120010290A1 (en) | 2008-12-04 | 2012-01-12 | Vath James E | Methods of Treating an Overweight or Obese Subject |
| WO2010065881A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| MX337575B (es) | 2009-10-09 | 2016-03-10 | Zafgen Corp | Compuestos de sulfona y métodos para lafabricación y uso de éstos. |
| PH12013500934A1 (en) * | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
-
2010
- 2010-11-09 PH PH1/2013/500934A patent/PH12013500934A1/en unknown
-
2011
- 2011-11-09 CN CN2011800600503A patent/CN103347870A/zh active Pending
- 2011-11-09 AU AU2011326566A patent/AU2011326566B2/en not_active Ceased
- 2011-11-09 UA UAA201307189A patent/UA111479C2/uk unknown
- 2011-11-09 EP EP11788684.6A patent/EP2638023B1/en active Active
- 2011-11-09 NZ NZ610569A patent/NZ610569A/en not_active IP Right Cessation
- 2011-11-09 JP JP2013538848A patent/JP6239977B2/ja not_active Expired - Fee Related
- 2011-11-09 SG SG2013035225A patent/SG190688A1/en unknown
- 2011-11-09 WO PCT/US2011/059966 patent/WO2012064838A1/en not_active Ceased
- 2011-11-09 EA EA201390675A patent/EA029941B1/ru not_active IP Right Cessation
- 2011-11-09 MX MX2013005208A patent/MX2013005208A/es active IP Right Grant
- 2011-11-09 KR KR1020137014698A patent/KR101892768B1/ko not_active Expired - Fee Related
- 2011-11-09 MY MYPI2013001644A patent/MY177039A/en unknown
- 2011-11-09 ES ES11788684.6T patent/ES2610216T3/es active Active
- 2011-11-09 BR BR112013011550A patent/BR112013011550A2/pt not_active Application Discontinuation
- 2011-11-09 CA CA2817199A patent/CA2817199C/en not_active Expired - Fee Related
- 2011-11-09 CN CN201710158431.4A patent/CN106905267A/zh active Pending
-
2012
- 2012-08-07 US US13/568,476 patent/US8349891B2/en not_active Expired - Fee Related
- 2012-11-16 US US13/679,310 patent/US8735447B2/en not_active Expired - Fee Related
-
2013
- 2013-05-08 IL IL226238A patent/IL226238B/en active IP Right Grant
-
2014
- 2014-02-12 US US14/178,788 patent/US9371312B2/en not_active Expired - Fee Related
-
2016
- 2016-05-03 US US15/145,403 patent/US9827221B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2638023A1 (en) | 2013-09-18 |
| JP6239977B2 (ja) | 2017-11-29 |
| US8735447B2 (en) | 2014-05-27 |
| JP2013543867A (ja) | 2013-12-09 |
| US20150018413A1 (en) | 2015-01-15 |
| AU2011326566A1 (en) | 2013-05-30 |
| MX2013005208A (es) | 2013-08-01 |
| US9371312B2 (en) | 2016-06-21 |
| NZ610569A (en) | 2015-06-26 |
| BR112013011550A2 (pt) | 2017-10-24 |
| EA201390675A1 (ru) | 2013-08-30 |
| SG190688A1 (en) | 2013-07-31 |
| EP2638023B1 (en) | 2016-09-07 |
| KR20140009994A (ko) | 2014-01-23 |
| CA2817199A1 (en) | 2012-05-18 |
| ES2610216T3 (es) | 2017-04-26 |
| KR101892768B1 (ko) | 2018-08-28 |
| MY177039A (en) | 2020-09-03 |
| WO2012064838A1 (en) | 2012-05-18 |
| EA029941B1 (ru) | 2018-06-29 |
| IL226238B (en) | 2019-02-28 |
| CN106905267A (zh) | 2017-06-30 |
| US8349891B2 (en) | 2013-01-08 |
| AU2011326566B2 (en) | 2016-12-01 |
| IL226238A0 (en) | 2013-07-31 |
| CA2817199C (en) | 2019-01-15 |
| CN103347870A (zh) | 2013-10-09 |
| US9827221B2 (en) | 2017-11-28 |
| US20170087119A1 (en) | 2017-03-30 |
| UA111479C2 (uk) | 2016-05-10 |
| US20120316233A1 (en) | 2012-12-13 |
| US20130197078A1 (en) | 2013-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY177039A (en) | Crystalline solids of a metap-2 inhibitor and methods of making and using same | |
| ZA201201365B (en) | Plant pathogen inhibitor combinations and methods of use | |
| WO2011053940A3 (en) | Templated nanoconjugates | |
| IL208656A0 (en) | Cyclic inhibitors of 11 beta-hydroxysteroid dehdrogenase 1 | |
| EP2622085A4 (en) | PREPARATION OF ALPHA OLEFINES USING POLYKETIDE SYNTHESES | |
| AU329302S (en) | A television receiver | |
| AU330208S (en) | Highchair | |
| EP2515677A4 (en) | Organically chelated mineral compositions and methods thereof | |
| EP2464435A4 (en) | Configurations and methods of generating low-pressure steam | |
| IL217015A0 (en) | Biosynthesis of 1-alkenes in engineered microorganisms | |
| AU329734S (en) | A television receiver | |
| EP2622029A4 (en) | PRINTING COLORING COMPOSITIONS AND METHOD FOR THEIR USE | |
| AU330031S (en) | Router | |
| PL2465772T3 (pl) | Mikro-generator strumieniowy strumieni syntetycznych | |
| MX2014013525A (es) | Sal polimorfica de la sal de oxalato de 6-o-(4-dimetilaminoetoxi)c inamoil fumagilol y metodos para elaborarla y utilizarla. | |
| EP2185627A4 (en) | COPOLYMERIZATION OF EPOXIDES AND CYCLIC ANHYDRIDES | |
| EP2409588A4 (en) | HEADBOARD CAPABLE OF INTEGRATING A PLAYER OF MP3 MUSIC | |
| AU330335S (en) | A television receiver | |
| EP2553574A4 (en) | CHARACTERISTICS FOR INDICATING THE AUDIO RECEIVABILITY OF A DRAWING DEVICE | |
| EP2545461A4 (en) | Dynamic grouping of domain objects via smart groups | |
| HK1189878A (en) | Crystalline solids of a metap-2 inhibitor and methods of making and using same | |
| GB0817434D0 (en) | Methods of obtaining novel plants and plants obtainable thereby | |
| IL215249A0 (en) | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | |
| CL2015003187A1 (es) | Combinaciones de inhibidor de patógenos de planta y métodos de uso. | |
| AU2009901029A0 (en) | Pre-Treatment of Aqueous Flotation Pulp |