AU2011326566B2 - Crystalline solids of a MetAP-2 inhibitor and methods of making and using same - Google Patents

Crystalline solids of a MetAP-2 inhibitor and methods of making and using same Download PDF

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Publication number
AU2011326566B2
AU2011326566B2 AU2011326566A AU2011326566A AU2011326566B2 AU 2011326566 B2 AU2011326566 B2 AU 2011326566B2 AU 2011326566 A AU2011326566 A AU 2011326566A AU 2011326566 A AU2011326566 A AU 2011326566A AU 2011326566 B2 AU2011326566 B2 AU 2011326566B2
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AU
Australia
Prior art keywords
crystalline
dimethylaminoethoxy
crystalline form
ray diffraction
diffraction pattern
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011326566A
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English (en)
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AU2011326566A1 (en
Inventor
Thomas Crawford
Hayley A. Reece
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Larimar Therapeutics Inc
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Zafgen Inc
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Publication of AU2011326566A1 publication Critical patent/AU2011326566A1/en
Application granted granted Critical
Publication of AU2011326566B2 publication Critical patent/AU2011326566B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/32—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2011326566A 2010-11-09 2011-11-09 Crystalline solids of a MetAP-2 inhibitor and methods of making and using same Ceased AU2011326566B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41165510P 2010-11-09 2010-11-09
US61/411,655 2010-11-09
PCT/US2011/059966 WO2012064838A1 (en) 2010-11-09 2011-11-09 Crystalline solids of a metap-2 inhibitor and methods of making and using same

Publications (2)

Publication Number Publication Date
AU2011326566A1 AU2011326566A1 (en) 2013-05-30
AU2011326566B2 true AU2011326566B2 (en) 2016-12-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011326566A Ceased AU2011326566B2 (en) 2010-11-09 2011-11-09 Crystalline solids of a MetAP-2 inhibitor and methods of making and using same

Country Status (18)

Country Link
US (4) US8349891B2 (enExample)
EP (1) EP2638023B1 (enExample)
JP (1) JP6239977B2 (enExample)
KR (1) KR101892768B1 (enExample)
CN (2) CN106905267A (enExample)
AU (1) AU2011326566B2 (enExample)
BR (1) BR112013011550A2 (enExample)
CA (1) CA2817199C (enExample)
EA (1) EA029941B1 (enExample)
ES (1) ES2610216T3 (enExample)
IL (1) IL226238B (enExample)
MX (1) MX2013005208A (enExample)
MY (1) MY177039A (enExample)
NZ (1) NZ610569A (enExample)
PH (1) PH12013500934A1 (enExample)
SG (1) SG190688A1 (enExample)
UA (1) UA111479C2 (enExample)
WO (1) WO2012064838A1 (enExample)

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WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
US9320805B2 (en) 2010-05-25 2016-04-26 Syndevrx, Inc. Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
US9895449B2 (en) 2010-05-25 2018-02-20 Syndevrx, Inc. Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
KR20130043207A (ko) 2010-07-22 2013-04-29 자프겐 인크. 트리시클릭 화합물 및 이의 제조 및 사용 방법
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CA2825408A1 (en) 2011-01-26 2012-08-02 Zafgen, Inc. Tetrazole compounds and methods of making and using same
KR101979039B1 (ko) 2011-05-06 2019-05-15 자프겐 인크. 부분 포화된 삼환식 화합물 및 그리고 그의 제조방법 및 그를 이용하는 방법
BR112013028666A2 (pt) 2011-05-06 2017-08-08 Zafgen Inc compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo
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CN104918615B (zh) 2012-11-05 2018-10-12 扎夫根股份有限公司 治疗肝病的方法
BR112015010225A2 (pt) 2012-11-05 2017-07-11 Zafgen Inc compostos tricíclicos e seus métodos de produção e utilização
US9868717B2 (en) 2012-11-05 2018-01-16 Zafgen, Inc. Tricyclic sulphonamide compounds and methods of making and using same
WO2014118180A1 (en) * 2013-01-30 2014-08-07 Sandoz Ag Crystalline form of linaclotide
PT2958916T (pt) * 2013-02-21 2018-11-21 Pfizer Formas sólidas de um inibidor de cdk4/6 seletivo
AU2014236528A1 (en) 2013-03-14 2015-09-24 Zafgen, Inc. Methods of treating renal disease and other disorders
BR112015025892A2 (pt) 2013-04-10 2017-07-25 Syndevrx Inc inibidores de metap2 e métodos para tratar obesidade
AR101608A1 (es) * 2014-08-22 2016-12-28 Zafgen Inc Formulaciones que contienen un inhibidor de metap-2
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KR102849342B1 (ko) 2015-12-10 2025-08-21 신데브알엑스, 인크. 푸마길롤 유도체 및 그의 다형체
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JP2022512826A (ja) 2018-10-26 2022-02-07 シンデブルックス，インコーポレイティド ＭｅｔＡＰ２阻害剤のバイオマーカーとその応用

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Also Published As

Publication number Publication date
EP2638023A1 (en) 2013-09-18
AU2011326566A1 (en) 2013-05-30
IL226238A0 (en) 2013-07-31
KR101892768B1 (ko) 2018-08-28
CA2817199C (en) 2019-01-15
JP2013543867A (ja) 2013-12-09
EA029941B1 (ru) 2018-06-29
ES2610216T3 (es) 2017-04-26
WO2012064838A1 (en) 2012-05-18
US8735447B2 (en) 2014-05-27
US8349891B2 (en) 2013-01-08
NZ610569A (en) 2015-06-26
US20170087119A1 (en) 2017-03-30
MX2013005208A (es) 2013-08-01
MY177039A (en) 2020-09-03
PH12013500934A1 (en) 2022-10-24
CN103347870A (zh) 2013-10-09
CA2817199A1 (en) 2012-05-18
US20150018413A1 (en) 2015-01-15
CN106905267A (zh) 2017-06-30
IL226238B (en) 2019-02-28
US20130197078A1 (en) 2013-08-01
EA201390675A1 (ru) 2013-08-30
JP6239977B2 (ja) 2017-11-29
EP2638023B1 (en) 2016-09-07
KR20140009994A (ko) 2014-01-23
UA111479C2 (uk) 2016-05-10
US20120316233A1 (en) 2012-12-13
SG190688A1 (en) 2013-07-31
US9827221B2 (en) 2017-11-28
BR112013011550A2 (pt) 2017-10-24
US9371312B2 (en) 2016-06-21

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