PE98998A1 - Marcfortinas y parahercuamidas 25-metilen y 24, 25 -epoxi substituidas - Google Patents
Marcfortinas y parahercuamidas 25-metilen y 24, 25 -epoxi substituidasInfo
- Publication number
- PE98998A1 PE98998A1 PE1997000686A PE00068697A PE98998A1 PE 98998 A1 PE98998 A1 PE 98998A1 PE 1997000686 A PE1997000686 A PE 1997000686A PE 00068697 A PE00068697 A PE 00068697A PE 98998 A1 PE98998 A1 PE 98998A1
- Authority
- PE
- Peru
- Prior art keywords
- cooh
- parahercuamidas
- marcfortines
- methylene
- alkylmarcfortine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (VII) o (VIII), QUE COMPRENDEN: (I) MARCFORTINA A, EN DONDE: n ES 1; R14 ES R14O:R14�; R15 ES R15O:R15�; R14 Y R15 SON H; (II) PARAHERCUAMIDA A, EN DONDE: n ES O; R14 ES R14O:R14�, DONDE R14O ES OH Y R14� ES CH3; R15 ES R15O:R15�, SIENDO R15 H; (III) 14-HIDROXI-14-ALQUILMARCFORTINA A, EN DONDE: n ES 1; R14 ES R14O:R14�, DONDE: R14O ES OH Y R14� ES ALQUILO C1-C4; R15 ES R15O:R15�, SIENDO R15 H; (IV) 14-HIDROXI-15-ALQUILMARCFORTINA A, EN DONDE: n ES 1; R14O:R14�, DONDE R14O ES OH Y R14� ES H; R15 ES R15O:R15�, DONDE R15O ES ALQUILO C1-C4 Y R15� ES H; Y A LAS SALES DE (VII) o (VIII) DEL GRUPO CONSTITUIDO DE LOS ACIDOS METANSULFONICO, HCl, HBr, H2SO4, H3PO4, HNO3, BENZOICO, CITRICO, TARTARICO, FUMARICO, MALEICO, CH3-(CH2)n-COOH Y COOH-(CH2)n-COOH, EN LOS CUALES n ES 0; 1; 2; 3 o 4. ESTOS COMPUESTOS SON UTILES COMO AGENTES ANTIPARASITOS CONTRA ENDOPARASITOS Y ECTOPARASITOS DE PREFERENCIA HELMINTOS (NEMATODOS) Y ARTROPODOS (GARRAPATAS Y ACAROS), CUYOS HUESPEDES SON HUMANOS, ANIMALES Y PLANTAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2598396P | 1996-09-09 | 1996-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE98998A1 true PE98998A1 (es) | 1998-12-24 |
Family
ID=21829160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000686A PE98998A1 (es) | 1996-09-09 | 1997-08-06 | Marcfortinas y parahercuamidas 25-metilen y 24, 25 -epoxi substituidas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5886180A (es) |
| EP (1) | EP0929555A1 (es) |
| JP (1) | JP2001500494A (es) |
| KR (1) | KR20000068471A (es) |
| CN (1) | CN1230188A (es) |
| AU (1) | AU4094597A (es) |
| BR (1) | BR9711721A (es) |
| CA (1) | CA2264052A1 (es) |
| CO (1) | CO4900069A1 (es) |
| CZ (1) | CZ51999A3 (es) |
| HU (1) | HUP0000264A2 (es) |
| NO (1) | NO991123L (es) |
| PE (1) | PE98998A1 (es) |
| PL (1) | PL332044A1 (es) |
| SK (1) | SK27499A3 (es) |
| TR (1) | TR199900496T2 (es) |
| WO (1) | WO1998009971A1 (es) |
| ZA (1) | ZA976761B (es) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075307A (en) * | 1987-07-28 | 1991-12-24 | Merck & Co., Inc. | Paraherquamide and dihydroparaherquamide as antihelminthic agents |
| US4873247A (en) * | 1987-11-27 | 1989-10-10 | Goegelman Robert T | Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents |
| US4978656A (en) * | 1988-08-12 | 1990-12-18 | Merck & Co., Inc. | Synthetic derivatives of paraherquamide |
| US4866060A (en) * | 1988-08-19 | 1989-09-12 | Merck & Co., Inc. | Use of the natural product marcfortines as antiparasitic agents |
| US4923867A (en) * | 1988-08-24 | 1990-05-08 | Merck & Co., Inc. | Synthetic marcfortine derivatives useful as antiparasitic agents |
| NZ233043A (en) * | 1989-03-30 | 1992-09-25 | Merck & Co Inc | Anthelmintic heterocyclic compounds prepared by action of cunninghamella blakesleeana on (dihydro)paraherquamide |
| IE904606A1 (en) * | 1989-12-21 | 1991-07-03 | Beecham Group Plc | Novel products |
| GB9014194D0 (en) * | 1990-06-26 | 1990-08-15 | Pfizer Ltd | Antiparasitic agents |
| WO1992022555A1 (en) * | 1991-06-17 | 1992-12-23 | Beecham Group Plc | Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents |
| TW410227B (en) * | 1993-06-16 | 2000-11-01 | Upjohn Co | 14-substituted marcfortines and derivatives useful as antiparasitic agents |
| TW334436B (en) * | 1995-07-21 | 1998-06-21 | Upjohn Co | Antiparasitic marcfortines and paraherquamides |
-
1997
- 1997-07-29 ZA ZA976761A patent/ZA976761B/xx unknown
- 1997-08-06 PE PE1997000686A patent/PE98998A1/es not_active Application Discontinuation
- 1997-09-05 BR BR9711721A patent/BR9711721A/pt not_active Application Discontinuation
- 1997-09-05 PL PL97332044A patent/PL332044A1/xx unknown
- 1997-09-05 US US08/924,347 patent/US5886180A/en not_active Expired - Fee Related
- 1997-09-05 AU AU40945/97A patent/AU4094597A/en not_active Abandoned
- 1997-09-05 CZ CZ99519A patent/CZ51999A3/cs unknown
- 1997-09-05 CN CN97197774A patent/CN1230188A/zh active Pending
- 1997-09-05 JP JP10512769A patent/JP2001500494A/ja active Pending
- 1997-09-05 CO CO97051585A patent/CO4900069A1/es unknown
- 1997-09-05 KR KR1019997001856A patent/KR20000068471A/ko not_active Application Discontinuation
- 1997-09-05 EP EP97938665A patent/EP0929555A1/en not_active Withdrawn
- 1997-09-05 HU HU0000264A patent/HUP0000264A2/hu unknown
- 1997-09-05 CA CA002264052A patent/CA2264052A1/en not_active Abandoned
- 1997-09-05 SK SK274-99A patent/SK27499A3/sk unknown
- 1997-09-05 WO PCT/US1997/015309 patent/WO1998009971A1/en not_active Application Discontinuation
- 1997-09-05 TR TR1999/00496T patent/TR199900496T2/xx unknown
-
1999
- 1999-03-08 NO NO991123A patent/NO991123L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA976761B (en) | 1999-01-29 |
| CA2264052A1 (en) | 1998-03-12 |
| PL332044A1 (en) | 1999-08-16 |
| CZ51999A3 (cs) | 1999-05-12 |
| KR20000068471A (ko) | 2000-11-25 |
| US5886180A (en) | 1999-03-23 |
| TR199900496T2 (xx) | 1999-06-21 |
| JP2001500494A (ja) | 2001-01-16 |
| AU4094597A (en) | 1998-03-26 |
| CO4900069A1 (es) | 2000-03-27 |
| WO1998009971A1 (en) | 1998-03-12 |
| HUP0000264A2 (hu) | 2000-06-28 |
| SK27499A3 (en) | 2000-02-14 |
| CN1230188A (zh) | 1999-09-29 |
| BR9711721A (pt) | 1999-08-24 |
| EP0929555A1 (en) | 1999-07-21 |
| NO991123D0 (no) | 1999-03-08 |
| NO991123L (no) | 1999-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |