CO4900069A1 - Marcfortinas y parahercuamidas 25-metilen y 24,25-epoxi substituidas - Google Patents
Marcfortinas y parahercuamidas 25-metilen y 24,25-epoxi substituidasInfo
- Publication number
- CO4900069A1 CO4900069A1 CO97051585A CO97051585A CO4900069A1 CO 4900069 A1 CO4900069 A1 CO 4900069A1 CO 97051585 A CO97051585 A CO 97051585A CO 97051585 A CO97051585 A CO 97051585A CO 4900069 A1 CO4900069 A1 CO 4900069A1
- Authority
- CO
- Colombia
- Prior art keywords
- methylene
- parahercuamides
- marcfortines
- epoxy
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Abstract
Compuestos 25-metilen substituidos de la fórmula (VII) en donde(I) Marcfortina A es:[2´R-(2´a, 3´aa, 9´aa, 10´aa)] - 3,4,6´,7´, 8´, 9´, 10´, 10´a- Octahidro-1´,1´,4,4, 12´- pentametil-3-metilenespiro [2H, 8H-[1,4] dioxepino [2,3-g] indol- 8,2´(3´H) - [1H,4H-3a, 9a](iminometano) ciclopenta [b] quinolizina]- 9,11´(10H)-diona(a) n es 1, (b) R14 es R14a : R14ß , en donde R14a es -H y R14ß es -H, (c) R15 es R15a : R15ß , en donde R15a es -H YR15ß es -H;(II) Parahercuamida A es: [1´R-(1´µ, 5´aß, 7´ß,8´aß, 9´aß]-2´,3,3´, 4,8´a,9´- Hexahidro-1´-hidroxi- 1´,4, 4´, 8,8´, 11´-hexametil-3-metilenespiro[2H,8H-[1,4] dioxepino[2,3-g] indol-8,7´(8´H)-[5H,6H-5a, 9a] (iminometano) [1H] ciclopent [f] indolizina]-9,10´(10H)-diona.(a) n es 0, (b) R14 es R14a R14ß , en donde R14a es -OH y R14ß es -CH3 ,(c) R15 es R15a : R15ß , en donde R15a es -H y R15ß es -H;(III) 14-Hidroxi-14-alquilmarcfortina A (a) n es 1, (b) R14 es R14a : R14ß , en donde R14a es -OH y R14ß , es C1 -C4 alquilo; (c) R15 es R15a : R15ß , en donde R15a es -H y R15ß es -H;(IV) 14-Hidroxi-15-alquilmarcforntina A (a) n es 1, (b) R14 es R14a : R14ß , en donde R14a es -OH y R14ß es -H,(c) R15 es R15a : R15ß , en donde R15a es C1 -C4 alquilo y R15ß es -H y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2598396P | 1996-09-09 | 1996-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900069A1 true CO4900069A1 (es) | 2000-03-27 |
Family
ID=21829160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97051585A CO4900069A1 (es) | 1996-09-09 | 1997-09-05 | Marcfortinas y parahercuamidas 25-metilen y 24,25-epoxi substituidas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5886180A (es) |
| EP (1) | EP0929555A1 (es) |
| JP (1) | JP2001500494A (es) |
| KR (1) | KR20000068471A (es) |
| CN (1) | CN1230188A (es) |
| AU (1) | AU4094597A (es) |
| BR (1) | BR9711721A (es) |
| CA (1) | CA2264052A1 (es) |
| CO (1) | CO4900069A1 (es) |
| CZ (1) | CZ51999A3 (es) |
| HU (1) | HUP0000264A2 (es) |
| NO (1) | NO991123L (es) |
| PE (1) | PE98998A1 (es) |
| PL (1) | PL332044A1 (es) |
| SK (1) | SK27499A3 (es) |
| TR (1) | TR199900496T2 (es) |
| WO (1) | WO1998009971A1 (es) |
| ZA (1) | ZA976761B (es) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075307A (en) * | 1987-07-28 | 1991-12-24 | Merck & Co., Inc. | Paraherquamide and dihydroparaherquamide as antihelminthic agents |
| US4873247A (en) * | 1987-11-27 | 1989-10-10 | Goegelman Robert T | Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents |
| US4978656A (en) * | 1988-08-12 | 1990-12-18 | Merck & Co., Inc. | Synthetic derivatives of paraherquamide |
| US4866060A (en) * | 1988-08-19 | 1989-09-12 | Merck & Co., Inc. | Use of the natural product marcfortines as antiparasitic agents |
| US4923867A (en) * | 1988-08-24 | 1990-05-08 | Merck & Co., Inc. | Synthetic marcfortine derivatives useful as antiparasitic agents |
| NZ233043A (en) * | 1989-03-30 | 1992-09-25 | Merck & Co Inc | Anthelmintic heterocyclic compounds prepared by action of cunninghamella blakesleeana on (dihydro)paraherquamide |
| IE904606A1 (en) * | 1989-12-21 | 1991-07-03 | Beecham Group Plc | Novel products |
| GB9014194D0 (en) * | 1990-06-26 | 1990-08-15 | Pfizer Ltd | Antiparasitic agents |
| WO1992022555A1 (en) * | 1991-06-17 | 1992-12-23 | Beecham Group Plc | Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents |
| TW410227B (en) * | 1993-06-16 | 2000-11-01 | Upjohn Co | 14-substituted marcfortines and derivatives useful as antiparasitic agents |
| TW334436B (en) * | 1995-07-21 | 1998-06-21 | Upjohn Co | Antiparasitic marcfortines and paraherquamides |
-
1997
- 1997-07-29 ZA ZA976761A patent/ZA976761B/xx unknown
- 1997-08-06 PE PE1997000686A patent/PE98998A1/es not_active Application Discontinuation
- 1997-09-05 CA CA002264052A patent/CA2264052A1/en not_active Abandoned
- 1997-09-05 HU HU0000264A patent/HUP0000264A2/hu unknown
- 1997-09-05 KR KR1019997001856A patent/KR20000068471A/ko not_active Application Discontinuation
- 1997-09-05 CZ CZ99519A patent/CZ51999A3/cs unknown
- 1997-09-05 AU AU40945/97A patent/AU4094597A/en not_active Abandoned
- 1997-09-05 JP JP10512769A patent/JP2001500494A/ja active Pending
- 1997-09-05 PL PL97332044A patent/PL332044A1/xx unknown
- 1997-09-05 CN CN97197774A patent/CN1230188A/zh active Pending
- 1997-09-05 BR BR9711721A patent/BR9711721A/pt not_active Application Discontinuation
- 1997-09-05 WO PCT/US1997/015309 patent/WO1998009971A1/en not_active Application Discontinuation
- 1997-09-05 TR TR1999/00496T patent/TR199900496T2/xx unknown
- 1997-09-05 CO CO97051585A patent/CO4900069A1/es unknown
- 1997-09-05 SK SK274-99A patent/SK27499A3/sk unknown
- 1997-09-05 US US08/924,347 patent/US5886180A/en not_active Expired - Fee Related
- 1997-09-05 EP EP97938665A patent/EP0929555A1/en not_active Withdrawn
-
1999
- 1999-03-08 NO NO991123A patent/NO991123L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL332044A1 (en) | 1999-08-16 |
| CN1230188A (zh) | 1999-09-29 |
| SK27499A3 (en) | 2000-02-14 |
| WO1998009971A1 (en) | 1998-03-12 |
| CZ51999A3 (cs) | 1999-05-12 |
| EP0929555A1 (en) | 1999-07-21 |
| TR199900496T2 (xx) | 1999-06-21 |
| AU4094597A (en) | 1998-03-26 |
| NO991123L (no) | 1999-05-07 |
| CA2264052A1 (en) | 1998-03-12 |
| BR9711721A (pt) | 1999-08-24 |
| KR20000068471A (ko) | 2000-11-25 |
| HUP0000264A2 (hu) | 2000-06-28 |
| JP2001500494A (ja) | 2001-01-16 |
| NO991123D0 (no) | 1999-03-08 |
| PE98998A1 (es) | 1998-12-24 |
| ZA976761B (en) | 1999-01-29 |
| US5886180A (en) | 1999-03-23 |
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