PE36098A1 - NEW HETEROARILOXAZOLIDINONES - Google Patents
NEW HETEROARILOXAZOLIDINONESInfo
- Publication number
- PE36098A1 PE36098A1 PE1997000072A PE00007297A PE36098A1 PE 36098 A1 PE36098 A1 PE 36098A1 PE 1997000072 A PE1997000072 A PE 1997000072A PE 00007297 A PE00007297 A PE 00007297A PE 36098 A1 PE36098 A1 PE 36098A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- compounds
- phenyl
- piridyl
- alcoxi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIEREN A LOS COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES D-R2, -CO-R3 o -CO-NR4R5, EN DONDE: "D" ES CO2 o SO2; R2 ES FENILO O ALQUILO C1-C7; R3 ES CF3 o ALQUILO C1-C6 QUE ESTA SUSTITUIDO CON HALOGENO O CF3; R4 Y R5 SON HIDROGENO, FENILO O ALQUILO C1-C5; "A" PREFERENTEMENTE ES TIENILO, PIRIDILO O QUINOLILO QUE EVENTUALMENTE ESTA SUSTITUIDO CON Cl, Br, ALQUILO C1-C5, ALCOXI C1-C5, o CON FENILO, PIRIDAZINILO, PIRIMIDILO O PIRIDILO QUE A SU VEZ PUEDEN ESTAR SUSTITUIDO CON ALQUILO C1-C5 o ALCOXI C1-C5, ENTRE OTROS. TAMBIEN SE REFIERE A LOS COMPUESTOS INTERMEDIOS EN LA PREPARACION Y AL PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS DE FORMULA (I). LOS COMPUESTOS OBTENIDOS PRESENTAN UNA BAJA TOXICIDAD CON UN AMPLIO ESPECTRO ANTIBACTERIANO, ESPECIALMENTE FRENTE A BACTERIAS GRAM POSITIVAS Y MICOBACTERIAS, ENTRE OTRASTHEY REFER TO THE COMPOUNDS OF FORMULA (I), WHERE: R1 IS D-R2, -CO-R3 or -CO-NR4R5, WHERE: "D" IS CO2 or SO2; R2 IS PHENYL OR C1-C7 ALKYL; R3 IS CF3 or C1-C6 ALKYL WHICH IS REPLACED WITH HALOGEN OR CF3; R4 AND R5 ARE HYDROGEN, PHENYL OR C1-C5 ALKYL; "A" PREFERABLY IS TIENYL, PIRIDYL, OR QUINOLYL THAT IS EVENTUALLY SUBSTITUTED WITH Cl, Br, C1-C5-ALKYL, ALCOXI C1-C5, OR WITH PHENYL, PIRIDAZINYL, OR PIRIDYL WHICH MAY BE SUARCOLATED o ALCOXI C1-C5, AMONG OTHERS. IT ALSO REFERS TO THE INTERMEDIATE COMPOUNDS IN THE PREPARATION AND TO THE PREPARATION PROCEDURE OF THE FORMULA COMPOUNDS (I). THE COMPOUNDS OBTAINED PRESENT A LOW TOXICITY WITH A WIDE ANTIBACTERIAL SPECTRUM, ESPECIALLY AGAINST POSITIVE GRAM BACTERIA AND MICOBACTERIA, AMONG OTHERS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19604224 | 1996-02-06 | ||
| DE19649095A DE19649095A1 (en) | 1996-02-06 | 1996-11-27 | New 5-(acyl-aminomethyl)-3-hetero-aryl-oxazolidinone compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE36098A1 true PE36098A1 (en) | 1998-08-29 |
Family
ID=7784634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000072A PE36098A1 (en) | 1996-02-06 | 1997-02-05 | NEW HETEROARILOXAZOLIDINONES |
Country Status (10)
| Country | Link |
|---|---|
| KR (1) | KR970061891A (en) |
| AR (1) | AR005704A1 (en) |
| CO (1) | CO4761067A1 (en) |
| DE (1) | DE19649095A1 (en) |
| PE (1) | PE36098A1 (en) |
| SV (1) | SV1997000010A (en) |
| TN (1) | TNSN97033A1 (en) |
| TW (1) | TW362974B (en) |
| YU (1) | YU4497A (en) |
| ZA (1) | ZA97928B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| DE19802239A1 (en) * | 1998-01-22 | 1999-07-29 | Bayer Ag | New oxazolidinone derivatives useful as antimicrobial agents against Gram-positive and some Gram-negative bacteria, mycobacteria, etc. |
| WO1999037630A1 (en) | 1998-01-23 | 1999-07-29 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US6562844B2 (en) | 1998-01-23 | 2003-05-13 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US7002020B1 (en) | 1998-01-23 | 2006-02-21 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| WO2006106426A1 (en) * | 2005-04-06 | 2006-10-12 | Pharmacia & Upjohn Company Llc | An oxindole oxazolidinone as antibacterial agent |
| AU2006231919A1 (en) | 2005-04-06 | 2006-10-12 | Pharmacia & Upjohn Company Llc | 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents |
| WO2008021337A1 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Oxazinan-2-one derivatives useful as pr modulators |
| TW200815428A (en) | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
-
1996
- 1996-11-27 DE DE19649095A patent/DE19649095A1/en not_active Withdrawn
-
1997
- 1997-02-04 AR ARP970100440A patent/AR005704A1/en unknown
- 1997-02-04 TN TNTNSN97033A patent/TNSN97033A1/en unknown
- 1997-02-04 TW TW086101260A patent/TW362974B/en active
- 1997-02-05 PE PE1997000072A patent/PE36098A1/en not_active Application Discontinuation
- 1997-02-05 YU YU4497A patent/YU4497A/en unknown
- 1997-02-05 KR KR1019970003609A patent/KR970061891A/en not_active Application Discontinuation
- 1997-02-05 ZA ZA9700928A patent/ZA97928B/en unknown
- 1997-02-06 CO CO97006152A patent/CO4761067A1/en unknown
- 1997-02-06 SV SV1997000010A patent/SV1997000010A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA97928B (en) | 1997-08-05 |
| SV1997000010A (en) | 1997-10-23 |
| KR970061891A (en) | 1997-09-12 |
| AR005704A1 (en) | 1999-07-14 |
| CO4761067A1 (en) | 1999-04-27 |
| TW362974B (en) | 1999-07-01 |
| DE19649095A1 (en) | 1997-08-07 |
| YU4497A (en) | 1999-09-27 |
| TNSN97033A1 (en) | 2005-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |