CO4761067A1 - NEW HETEROALIOXAZOLIDINONES - Google Patents

NEW HETEROALIOXAZOLIDINONES

Info

Publication number
CO4761067A1
CO4761067A1 CO97006152A CO97006152A CO4761067A1 CO 4761067 A1 CO4761067 A1 CO 4761067A1 CO 97006152 A CO97006152 A CO 97006152A CO 97006152 A CO97006152 A CO 97006152A CO 4761067 A1 CO4761067 A1 CO 4761067A1
Authority
CO
Colombia
Prior art keywords
straight
carbon atoms
substituted
different
same
Prior art date
Application number
CO97006152A
Other languages
Spanish (es)
Inventor
Bernd Riedl
Dieter Habich
Andreas Stolle
Martin Ruppelt
Stephan Bartel
Walter Guarnieri
Amm Raomer Emder
Hein-Peter Kroll
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CO4761067A1 publication Critical patent/CO4761067A1/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Heteroariloxazolidinonas de fórmula general (I)en la queR1 es un resto de fórmula -D-R2 , -CO-R3 o -CO-NR4 R5 ,dondeD es el grupo CO2 o el grupo SO2 ,R2 es fenilo o alquilo de cadena lineal o ramificada con hasta 7 átomos de carbono,R3 es trifluorometilo o alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono, que está sustituido con halógeno o trifluorometilo,R4 y R5 son iguales o diferentes y son hidrógeno, fenilo o alquilo de cadena lineal o ramificada con hasta 5 átomos de carbono,A es un heterociclo aromático de 6 elementos unido directamente por un átomo de carbono, con al menos un átomo de nitrógeno, o es en su caso un resto aromático bicíclico o tricíclico de 6 elementos cada uno, unido directamente por un átomo de carbono, con al menos un anillo que contiene nitrógeno, o es ß-carbonil-3-ilo o es indolizinilo unido directamente por el anillo de 6 elementos, o es un heterociclo aromático de 5 elementos unido directamente por un átomo de carbono, con hasta 3 heteroátomos de la serie del S, N y/u O, que adicionalmente puede tener fusionado un anillo de benceno o de naftilo, en el que todos los ciclos están eventualmente sustituidos hasta 3 veces cada uno de ellos de forma igual o distinta con carboxi, halógeno, ciano,mercapto, formilo, trifluorometilo, nitro, alcoxi, alcoxicarbonilo, tioalquilo o acilo de cadena lineal o ramificada, cada uno deellos con hasta 6 átomos de carbono o están sustituidos con alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono, que a su vez puede estar sustituido con hidroxi, con alcoxi o acilo de cadena lineal o ramificada con hasta 5 átomos de carbono o con un grupo de fórmula -NR6´ R7´ ,en la que R6 y R7 son iguales o distintos y son hidrógeno, cicloalquilo con 3 hasta 6 átomos de carbono o alquilo de cadena lineal o ramificada con hasta 5 átomos de carbono o fenilo, o junto con el átomo de nitrógeno forman un heterociclo saturado de 5 a 6 elementos eventualmente con otro heteroátomo de la serie del N, S y/u O, que a su vez eventualmente puede estar sustituido en otro átomo de nitrógeno con un alquilo o acilo de cadena lineal o ramificada con hasta 3 átomos de carbono, y/olos ciclos están sustituidos eventualmente con un grupo de fórmula -NR6 R7 ,en la queR6´ y R7´ son iguales o distintos y tienen el significado anteriormente citado de R6 y R7 y pueden ser iguales o distintos a éstos,y/olos ciclos están sustituidos eventualmente con un alquenil(C2 -C8 )fenilo, fenilo o con un heterociclo saturado o insaturado de 5 ó 6 elementos con hasta 3 heteroátomos de la serie del S, N y/u O, que a su vez está sustituido eventualmente con un grupo de fórmula -CO-NR8 R9 , NR10 R11 , NR12 -S(O)2 -R13 , R14 R15 N-SO2 o R16 -S(O)a ,a es el número 0, 1 ó 2,R8 , R9 , R12 , R14 y R15 son iguales o distintos y son hidrógeno, alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono o fenilo,R10 y R11 son iguales o distintos y son lo citado anteriormente para R6 y R7 y pueden ser iguales o distintos a éstos,R13 y R16 son iguales o distintos y son alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono o fenilo, que eventualmente está sustituido con alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono,y/o a su vez puede estar eventualmente sustituido hasta dos veces de forma igual o distinta con carboxi, halógeno, ciano, mercapto, formilo, trifluorometilo, nitro, fenilo, alcoxi, alcoxi carbonilo, tioalquilo o acilo de cadena lineal o ramificada, cada uno de ellos con hasta 6 átomos de carbono o están sustituidos con alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono, que a su vez puede estar sustituido con hidroxi, con alcoxi o acilo de cadena lineal o ramificada con hasta 5 átomos de carbono o con un grupo de fórmula AND#8209;NR17 R18 ,en la queR17 y R18 tienen el significado citado anteriormente para R6 y R7 y pueden ser iguales o distintos a éstos,y/olos ciclos eventualmente están sustituidos con un resto de fórmuladondenes el número 0, 1 ó 2y sus estereoisómeros, mezclas de estereoisómeros y sus sales.Heteroaryloxazolidinones of general formula (I) in which R1 is a residue of formula -D-R2, -CO-R3 or -CO-NR4 R5, where D is the group CO2 or the group SO2, R2 is phenyl or straight chain alkyl or branched with up to 7 carbon atoms, R3 is trifluoromethyl or straight chain alkyl or branched with up to 6 carbon atoms, which is substituted by halogen or trifluoromethyl, R4 and R5 are the same or different and are hydrogen, phenyl or straight chain alkyl or branched with up to 5 carbon atoms, A is a 6-element aromatic heterocycle linked directly by a carbon atom, with at least one nitrogen atom, or is in its case a bicyclic or tricyclic aromatic moiety of 6 elements each, directly attached by a carbon atom, with at least one nitrogen-containing ring, is either ß-carbonyl-3-yl or is indoxyzinyl directly linked by the 6-element ring, or is a 5-element aromatic heterocycle directly linked by a carbon atom, with up to 3 heteroatoms of the S, N and / or O series, which may additionally have a benzene or naphthyl ring fused, in which all the cycles are eventually substituted up to 3 times each in the same or different way with carboxy, halogen, cyano, mercapto, formyl, trifluoromethyl, nitro, alkoxy, alkoxycarbonyl, thioalkyl or straight or branched chain acyl, each containing up to 6 carbon atoms or substituted by straight or branched chain alkyl with up to 6 carbon atoms, which in turn can be substituted with hydroxy, with alkoxy or acyl of straight or branched chain with up to 5 carbon atoms or with a group of formula -NR6´ R7´, in which R6 and R7 are the same or different and are hydrogen, cycloalkyl with 3 to 6 carbon atoms or straight or branched chain alkyl with up to 5 carbon or phenyl atoms, or together with the nitrogen atom they form a saturated heterocycle of 5 to 6 elements, eventually with another hetero atom of the N, S and / or O series, which in turn may eventually be substituted on another nitrogen atom with a straight or branched chain alkyl or acyl with up to 3 carbon atoms, and / or the cycles are substituted optionally with a group of the formula -NR6 R7, in which R6 'and R7' are the same or different and have the aforementioned meaning of R6 and R7 and may be the same or different from these, and / or the cycles are optionally substituted with an alkenyl (C2-C8) phenyl, phenyl or with a saturated or unsaturated 5- or 6-membered heterocycle with up to 3 heteroatoms of the S, N and / or O series, which in turn is optionally substituted with a group of the formula -CO -NR8 R9, NR10 R11, NR12 -S (O) 2 -R13, R14 R15 N-SO2 or R16 -S (O) a, a is the number 0, 1 or 2, R8, R9, R12, R14 and R15 are the same or different and are hydrogen, straight or branched chain alkyl with up to 6 carbon or phenyl atoms, R10 and R11 are the same or different and are as cited Subsequently for R6 and R7 and may be the same or different from these, R13 and R16 are the same or different and are straight or branched chain alkyl with up to 4 carbon atoms or phenyl, which is optionally substituted with straight or branched chain alkyl with up to 4 carbon atoms, and / or in turn may optionally be substituted up to twice equally or differently with carboxy, halogen, cyano, mercapto, formyl, trifluoromethyl, nitro, phenyl, alkoxy, alkoxycarbonyl, thioalkyl or chain acyl linear or branched, each containing up to 6 carbon atoms or substituted with straight or branched chain alkyl with up to 6 carbon atoms, which in turn may be substituted by hydroxy, alkoxy or straight or branched chain acyl with up to 5 carbon atoms or with a group of the formula AND # 8209; NR17 R18, in which R17 and R18 have the meaning mentioned above for R6 and R7 and may be the same or different from these, and / or the event cycles ually they are substituted with a residue of the formula where the number is 0, 1 or 2 and their stereoisomers, mixtures of stereoisomers and their salts.

CO97006152A 1996-02-06 1997-02-06 NEW HETEROALIOXAZOLIDINONES CO4761067A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19604224 1996-02-06
DE19649095A DE19649095A1 (en) 1996-02-06 1996-11-27 New 5-(acyl-aminomethyl)-3-hetero-aryl-oxazolidinone compounds

Publications (1)

Publication Number Publication Date
CO4761067A1 true CO4761067A1 (en) 1999-04-27

Family

ID=7784634

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97006152A CO4761067A1 (en) 1996-02-06 1997-02-06 NEW HETEROALIOXAZOLIDINONES

Country Status (10)

Country Link
KR (1) KR970061891A (en)
AR (1) AR005704A1 (en)
CO (1) CO4761067A1 (en)
DE (1) DE19649095A1 (en)
PE (1) PE36098A1 (en)
SV (1) SV1997000010A (en)
TN (1) TNSN97033A1 (en)
TW (1) TW362974B (en)
YU (1) YU4497A (en)
ZA (1) ZA97928B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19802239A1 (en) * 1998-01-22 1999-07-29 Bayer Ag New oxazolidinone derivatives useful as antimicrobial agents against Gram-positive and some Gram-negative bacteria, mycobacteria, etc.
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
AU764184B2 (en) * 1998-01-23 2003-08-14 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
WO2006106426A1 (en) * 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc An oxindole oxazolidinone as antibacterial agent
TW200815428A (en) 2006-08-15 2008-04-01 Wyeth Corp Oxazolidone derivatives as PR modulators
WO2008021337A1 (en) 2006-08-15 2008-02-21 Wyeth Oxazinan-2-one derivatives useful as pr modulators

Also Published As

Publication number Publication date
DE19649095A1 (en) 1997-08-07
TW362974B (en) 1999-07-01
PE36098A1 (en) 1998-08-29
AR005704A1 (en) 1999-07-14
KR970061891A (en) 1997-09-12
TNSN97033A1 (en) 2005-03-15
SV1997000010A (en) 1997-10-23
ZA97928B (en) 1997-08-05
YU4497A (en) 1999-09-27

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