PE20240689A1 - Anticuerpos y peptidos de union a antigenos para inhibidores del factor xia y uso de los mismos - Google Patents
Anticuerpos y peptidos de union a antigenos para inhibidores del factor xia y uso de los mismosInfo
- Publication number
- PE20240689A1 PE20240689A1 PE2023002024A PE2023002024A PE20240689A1 PE 20240689 A1 PE20240689 A1 PE 20240689A1 PE 2023002024 A PE2023002024 A PE 2023002024A PE 2023002024 A PE2023002024 A PE 2023002024A PE 20240689 A1 PE20240689 A1 PE 20240689A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- amino acid
- acid sequence
- group
- sequence selected
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 6
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 102000003827 Plasma Kallikrein Human genes 0.000 abstract 1
- 108090000113 Plasma Kallikrein Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invencion proporciona peptidos de union a antigenos, tales como un anticuerpo o fragmento de anticuerpo, que se unen especificamente a inhibidores selectivos de FXIa y/o inhibidores duales de FXIa y calicreina plasmatica. Ademas, se refiere a metodos para reducir el efecto antitrombotico de los inhibidores de FXIa mediante la administracion a un sujeto de una dosis farmaceuticamente eficaz de los peptidos de union a antigeno proporcionados en el presente documento. Tambien proporciona reactivos de deteccion y metodos para detectar el nivel de inhibidores de FXIa en una muestra biologica. En particular, la presente invencion se refiere a un peptido de union a antigeno aislado que comprende al menos una region variable de cadena pesada (VH) y al menos una region variable de cadena ligera (VL), en donde al menos una VH comprende al menos uno de: (a) una region determinante de complementariedad de VH 1 (VH-CDR1) que comprende una secuencia de aminoacidos seleccionada del grupo que consiste en las SEQ ID NO: 1-12; (b) una VH-CDR2 que comprende una secuencia de aminoacidos seleccionada del grupo que consta de SEQ ID NO: 13-22; o (c) una VH-CDR3 que comprende una secuencia de aminoacidos seleccionada del grupo que consta de SEQ ID NO: 23-28; y en donde el al menos una VL comprende al menos una de: (d) una VL-CDR1 que comprende una secuencia de aminoacidos seleccionada del grupo que consta de SEQ ID NO: 29-37; (e) una VL-CDR2 que comprende una secuencia de aminoacidos seleccionada del grupo que consta de SEQ ID NO: 38-43; o (f) una VL-CDR3 que comprende una secuencia de aminoacidos seleccionada del grupo que consta de SEQ ID NO: 44-51.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163135016P | 2021-01-08 | 2021-01-08 | |
| US202163148767P | 2021-02-12 | 2021-02-12 | |
| US202163152595P | 2021-02-23 | 2021-02-23 | |
| US202163153045P | 2021-02-24 | 2021-02-24 | |
| PCT/US2022/011669 WO2022150624A1 (en) | 2021-01-08 | 2022-01-07 | Antibodies and antigen binding peptides for factor xia inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240689A1 true PE20240689A1 (es) | 2024-04-10 |
Family
ID=82322604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023002024A PE20240689A1 (es) | 2021-01-08 | 2022-01-07 | Anticuerpos y peptidos de union a antigenos para inhibidores del factor xia y uso de los mismos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220220220A1 (es) |
| EP (1) | EP4274854A1 (es) |
| JP (1) | JP2024505390A (es) |
| KR (1) | KR20230142724A (es) |
| AU (1) | AU2022205370A1 (es) |
| CA (1) | CA3204552A1 (es) |
| CL (1) | CL2023001997A1 (es) |
| CO (1) | CO2023010266A2 (es) |
| IL (1) | IL304210A (es) |
| MX (1) | MX2023008142A (es) |
| PE (1) | PE20240689A1 (es) |
| TW (1) | TW202241964A (es) |
| WO (1) | WO2022150624A1 (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039067A1 (es) * | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| BRPI0607238B8 (pt) * | 2005-01-27 | 2021-05-25 | Novimmune Sa | anticorpos anti-interferon gama humano, usos dos mesmos na preparação de medicamentos e composições farmacêuticas |
| CN101522716B (zh) * | 2006-10-02 | 2013-03-20 | 瑞泽恩制药公司 | 抗人il-4受体的高亲和力人抗体 |
| GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| CA2874083C (en) * | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
| CN114470192A (zh) * | 2015-10-13 | 2022-05-13 | 优瑞科生物技术公司 | 对人类cd19具有专一性的抗体药剂和其用途 |
-
2022
- 2022-01-07 CA CA3204552A patent/CA3204552A1/en active Pending
- 2022-01-07 JP JP2023541614A patent/JP2024505390A/ja active Pending
- 2022-01-07 EP EP22737195.2A patent/EP4274854A1/en active Pending
- 2022-01-07 KR KR1020237026819A patent/KR20230142724A/ko unknown
- 2022-01-07 AU AU2022205370A patent/AU2022205370A1/en active Pending
- 2022-01-07 MX MX2023008142A patent/MX2023008142A/es unknown
- 2022-01-07 TW TW111100748A patent/TW202241964A/zh unknown
- 2022-01-07 WO PCT/US2022/011669 patent/WO2022150624A1/en active Application Filing
- 2022-01-07 US US17/570,649 patent/US20220220220A1/en active Pending
- 2022-01-07 PE PE2023002024A patent/PE20240689A1/es unknown
-
2023
- 2023-07-03 IL IL304210A patent/IL304210A/en unknown
- 2023-07-07 CL CL2023001997A patent/CL2023001997A1/es unknown
- 2023-08-01 CO CONC2023/0010266A patent/CO2023010266A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL304210A (en) | 2023-09-01 |
| CL2023001997A1 (es) | 2023-12-15 |
| CA3204552A1 (en) | 2022-07-14 |
| MX2023008142A (es) | 2023-09-08 |
| CO2023010266A2 (es) | 2023-09-18 |
| KR20230142724A (ko) | 2023-10-11 |
| WO2022150624A1 (en) | 2022-07-14 |
| TW202241964A (zh) | 2022-11-01 |
| US20220220220A1 (en) | 2022-07-14 |
| JP2024505390A (ja) | 2024-02-06 |
| AU2022205370A1 (en) | 2023-08-24 |
| EP4274854A1 (en) | 2023-11-15 |
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