PE20212178A1 - Compuestos de hexahidro-1h-pirazino[1,2-a]pirazina para el tratamiento de una enfermedad autoinmunitaria - Google Patents
Compuestos de hexahidro-1h-pirazino[1,2-a]pirazina para el tratamiento de una enfermedad autoinmunitariaInfo
- Publication number
- PE20212178A1 PE20212178A1 PE2021001647A PE2021001647A PE20212178A1 PE 20212178 A1 PE20212178 A1 PE 20212178A1 PE 2021001647 A PE2021001647 A PE 2021001647A PE 2021001647 A PE2021001647 A PE 2021001647A PE 20212178 A1 PE20212178 A1 PE 20212178A1
- Authority
- PE
- Peru
- Prior art keywords
- hexahydro
- pyrazino
- treatment
- autoimmune disease
- pyrazine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019081900 | 2019-04-09 | ||
| CN2019121598 | 2019-11-28 | ||
| CN2020078225 | 2020-03-06 | ||
| PCT/EP2020/059831 WO2020207991A1 (en) | 2019-04-09 | 2020-04-07 | Hexahydro-1h-pyrazino[1,2-a]pyrazine compounds for the treatment of autoimmune disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20212178A1 true PE20212178A1 (es) | 2021-11-09 |
Family
ID=70228042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2021001647A PE20212178A1 (es) | 2019-04-09 | 2020-04-07 | Compuestos de hexahidro-1h-pirazino[1,2-a]pirazina para el tratamiento de una enfermedad autoinmunitaria |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20220340597A1 (https=) |
| EP (1) | EP3953356B1 (https=) |
| JP (1) | JP7692838B2 (https=) |
| KR (1) | KR20210149163A (https=) |
| CN (1) | CN113710672B (https=) |
| AU (1) | AU2020272467A1 (https=) |
| BR (1) | BR112021020297A2 (https=) |
| CA (1) | CA3135129A1 (https=) |
| CL (1) | CL2021002621A1 (https=) |
| CO (1) | CO2021013166A2 (https=) |
| CR (1) | CR20210513A (https=) |
| IL (1) | IL286870A (https=) |
| MA (1) | MA55594A (https=) |
| MX (1) | MX2021012223A (https=) |
| PE (1) | PE20212178A1 (https=) |
| PH (1) | PH12021552533A1 (https=) |
| SG (1) | SG11202110401WA (https=) |
| TW (1) | TW202104230A (https=) |
| WO (1) | WO2020207991A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021084022A1 (en) * | 2019-10-31 | 2021-05-06 | F. Hoffmann-La Roche Ag | Hydropyrazino[1,2-d][1,4]diazepine compounds for the treatment of autoimmune disease |
| CN114728959B (zh) * | 2019-11-12 | 2024-11-12 | 豪夫迈·罗氏有限公司 | 用于治疗自身免疫性疾病的氢吡嗪并[1,2-b]异喹啉化合物 |
| US12503471B2 (en) | 2019-11-19 | 2025-12-23 | Hoffmann-La Roche Inc. | Triazatricycle compounds for the treatment of autoimmune disease |
| CN114728976B (zh) | 2019-11-19 | 2024-08-16 | 豪夫迈·罗氏有限公司 | 用于治疗自身免疫性疾病的氢-1H-吡咯并[1,2-a]吡嗪化合物 |
| KR20220122637A (ko) | 2019-11-28 | 2022-09-02 | 바이엘 악티엔게젤샤프트 | 면역 활성화를 위한 dgk알파 억제제로서의 치환된 아미노퀴놀론 |
| WO2021110614A1 (en) * | 2019-12-03 | 2021-06-10 | F. Hoffmann-La Roche Ag | HYDROPYRIDO[1,2-α]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE |
| US20240317735A1 (en) * | 2020-07-14 | 2024-09-26 | Hoffmann-La Roche Inc. | Hydroisoquinoline or hydronaphthyridine compounds for the treatment of autoimmune disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103562201B (zh) * | 2011-01-12 | 2016-10-19 | 帆德制药股份有限公司 | 作为toll样受体调节剂的取代的苯并氮杂卓 |
| RS56747B1 (sr) | 2012-09-14 | 2018-03-30 | Hoffmann La Roche | Pirazol derivati karboksamida kao taar modulatori za upotrebu u lečenju nekoliko poremećaja, kao što su depresija, dijabetes i parkinsonova bolest |
| CN105992766A (zh) * | 2013-12-13 | 2016-10-05 | 武田药品工业株式会社 | 作为tlr抑制剂的吡咯并[3,2-c]吡啶衍生物 |
| CA3005766A1 (en) | 2015-12-17 | 2017-06-22 | Merck Patent Gmbh | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders |
| EP3807271A1 (en) * | 2018-06-13 | 2021-04-21 | F. Hoffmann-La Roche AG | Pyridinyl heterocyclyl compounds for the treatment of autoimmune disease |
| JP2022501401A (ja) * | 2018-09-27 | 2022-01-06 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 自己免疫疾患の治療のためのヘテロシクリル化合物 |
-
2020
- 2020-04-07 MX MX2021012223A patent/MX2021012223A/es unknown
- 2020-04-07 MA MA055594A patent/MA55594A/fr unknown
- 2020-04-07 CA CA3135129A patent/CA3135129A1/en active Pending
- 2020-04-07 CN CN202080030189.2A patent/CN113710672B/zh active Active
- 2020-04-07 CR CR20210513A patent/CR20210513A/es unknown
- 2020-04-07 BR BR112021020297A patent/BR112021020297A2/pt not_active Application Discontinuation
- 2020-04-07 SG SG11202110401WA patent/SG11202110401WA/en unknown
- 2020-04-07 AU AU2020272467A patent/AU2020272467A1/en not_active Abandoned
- 2020-04-07 PH PH1/2021/552533A patent/PH12021552533A1/en unknown
- 2020-04-07 PE PE2021001647A patent/PE20212178A1/es unknown
- 2020-04-07 JP JP2021559754A patent/JP7692838B2/ja active Active
- 2020-04-07 EP EP20717841.9A patent/EP3953356B1/en active Active
- 2020-04-07 KR KR1020217036391A patent/KR20210149163A/ko not_active Withdrawn
- 2020-04-07 WO PCT/EP2020/059831 patent/WO2020207991A1/en not_active Ceased
- 2020-04-07 US US17/602,057 patent/US20220340597A1/en not_active Abandoned
- 2020-04-08 TW TW109111749A patent/TW202104230A/zh unknown
-
2021
- 2021-09-30 CO CONC2021/0013166A patent/CO2021013166A2/es unknown
- 2021-09-30 IL IL286870A patent/IL286870A/en unknown
- 2021-10-06 CL CL2021002621A patent/CL2021002621A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12021552533A1 (en) | 2022-06-20 |
| CN113710672A (zh) | 2021-11-26 |
| AU2020272467A1 (en) | 2021-10-14 |
| EP3953356A1 (en) | 2022-02-16 |
| CO2021013166A2 (es) | 2021-12-10 |
| SG11202110401WA (en) | 2021-10-28 |
| CR20210513A (es) | 2021-11-02 |
| IL286870A (en) | 2021-10-31 |
| TW202104230A (zh) | 2021-02-01 |
| WO2020207991A1 (en) | 2020-10-15 |
| KR20210149163A (ko) | 2021-12-08 |
| BR112021020297A2 (pt) | 2021-12-14 |
| CA3135129A1 (en) | 2020-10-15 |
| CN113710672B (zh) | 2025-01-03 |
| EP3953356B1 (en) | 2023-07-26 |
| US20220340597A1 (en) | 2022-10-27 |
| MA55594A (fr) | 2022-02-16 |
| JP2022527588A (ja) | 2022-06-02 |
| JP7692838B2 (ja) | 2025-06-16 |
| CL2021002621A1 (es) | 2022-05-13 |
| MX2021012223A (es) | 2021-11-03 |
| EP3953356C0 (en) | 2023-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20212178A1 (es) | Compuestos de hexahidro-1h-pirazino[1,2-a]pirazina para el tratamiento de una enfermedad autoinmunitaria | |
| PE20190656A1 (es) | Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 | |
| PE20170189A1 (es) | Nuevos derivados de pirazolo pirimidina y su uso como inhibidores de malt1 | |
| CY1126367T1 (el) | Παραγωγο βενζαζεπινης, μεθοδος παρασκευης, φαρμακευτικη συνθεση και χρηση αυτης | |
| CL2019002032A1 (es) | Procesos para preparar un inhibidor de jak1 (divisional de solicitud 1790-2018). | |
| PE20190518A1 (es) | Inhibidores de diacilglicerol aciltransferasa 2 | |
| CY1121231T1 (el) | Παραγωγο τετραϋδροϊμιδαζο[1,5-d][1,4]οξαζεπινης | |
| PE20210131A1 (es) | COMPUESTOS TETRAHIDRO-1H-PIRAZINO[2,1-a]ISOINDOLILQUINOLINA PARA EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES | |
| PE20241068A1 (es) | Moduladores de profarmacos de la via de estres integrada | |
| PE20181093A1 (es) | Compuestos heterociclicos y usos de los mismos | |
| PE20210163A1 (es) | Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 | |
| PE20200936A1 (es) | Dihidrooxadiazinonas | |
| PE20191613A1 (es) | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret | |
| CL2017001426A1 (es) | Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales. | |
| PE20190326A1 (es) | Isoquinolin-3-il-carboxamidas y preparacion y uso de las mismas | |
| PE20190395A1 (es) | Pirimidin-2-ilamino-1h-pirazoles como inhibidores de lrrk2 para el uso en el tratamiento de trastornos neurodegenerativos | |
| AR041184A1 (es) | Derivados de benzopiranonas, inhibidores de las cinasas dependientes de ciclinas y su uso | |
| PE20160005A1 (es) | Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades | |
| AR071833A1 (es) | Inhibidores de quinasas (limk2), composiciones que los comprenden y metodos para tratar o prevenir enfermedades | |
| PE20011371A1 (es) | Derivados de 3-(3-isopropil-5-metil-4h-1,2,4-triazol-4-il)-exo-8-azabiciclo[3.2.1]octano como antagonistas de los receptores de quimiocina ccr5 | |
| AR054560A1 (es) | Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
| PE20070805A1 (es) | Imidazopirazinas como inhibidores de proteinquinasa | |
| PE20220567A1 (es) | Nuevos derivados piperidinilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
| PE20200341A1 (es) | Composiciones y compuestos terapeuticos y metodos para utilizarlos | |
| PE20171348A1 (es) | Compuestos de benzoxaborol 4-sustituidos y uso de los mismos |