PE20211976A1 - Composiciones de liberacion retardada de linaclotida - Google Patents
Composiciones de liberacion retardada de linaclotidaInfo
- Publication number
- PE20211976A1 PE20211976A1 PE2021000748A PE2021000748A PE20211976A1 PE 20211976 A1 PE20211976 A1 PE 20211976A1 PE 2021000748 A PE2021000748 A PE 2021000748A PE 2021000748 A PE2021000748 A PE 2021000748A PE 20211976 A1 PE20211976 A1 PE 20211976A1
- Authority
- PE
- Peru
- Prior art keywords
- linaclotide
- delayed release
- composition
- histidine
- coated tablet
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000003111 delayed effect Effects 0.000 title abstract 3
- KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 abstract 4
- 229960000812 linaclotide Drugs 0.000 abstract 4
- 108010024409 linaclotide Proteins 0.000 abstract 4
- 206010010774 Constipation Diseases 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 239000002662 enteric coated tablet Substances 0.000 abstract 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 abstract 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 abstract 2
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 abstract 2
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract 1
- 229920002907 Guar gum Polymers 0.000 abstract 1
- 235000021355 Stearic acid Nutrition 0.000 abstract 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 abstract 1
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000002702 enteric coating Substances 0.000 abstract 1
- 238000009505 enteric coating Methods 0.000 abstract 1
- 239000000665 guar gum Substances 0.000 abstract 1
- 235000010417 guar gum Nutrition 0.000 abstract 1
- 229960002154 guar gum Drugs 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- RYXDAMAEMNKYMP-UHFFFAOYSA-N methyl 2,5-dimethyl-4-oxohexa-2,5-dienoate Chemical compound COC(=O)C(C)=CC(=O)C(C)=C RYXDAMAEMNKYMP-UHFFFAOYSA-N 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 abstract 1
- 239000000661 sodium alginate Substances 0.000 abstract 1
- 235000010413 sodium alginate Nutrition 0.000 abstract 1
- 229940005550 sodium alginate Drugs 0.000 abstract 1
- 239000008117 stearic acid Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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- A61K9/2022—Organic macromolecular compounds
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- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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- A61K9/4825—Proteins, e.g. gelatin
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914951P | 2013-12-11 | 2013-12-11 | |
| US201361914952P | 2013-12-11 | 2013-12-11 | |
| PCT/US2014/069838 WO2015089326A1 (en) | 2013-12-11 | 2014-12-11 | Delayed release compositions of linaclotide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20211976A1 true PE20211976A1 (es) | 2021-10-05 |
Family
ID=52293217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2021000748A PE20211976A1 (es) | 2013-12-11 | 2014-12-11 | Composiciones de liberacion retardada de linaclotida |
| PE2016000804A PE20161373A1 (es) | 2013-12-11 | 2014-12-11 | Composiciones de liberacion retardada de linaclotida |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016000804A PE20161373A1 (es) | 2013-12-11 | 2014-12-11 | Composiciones de liberacion retardada de linaclotida |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US20160310559A1 (enExample) |
| EP (2) | EP3079669B1 (enExample) |
| JP (4) | JP6964380B2 (enExample) |
| KR (3) | KR102337809B1 (enExample) |
| CN (3) | CN112569199A (enExample) |
| AU (3) | AU2014362220B2 (enExample) |
| CA (1) | CA2933587C (enExample) |
| CL (1) | CL2016001424A1 (enExample) |
| CY (1) | CY1123953T1 (enExample) |
| DK (1) | DK3079669T3 (enExample) |
| EA (1) | EA201691216A1 (enExample) |
| EC (2) | ECSP16059106A (enExample) |
| ES (1) | ES2838007T3 (enExample) |
| HR (1) | HRP20201753T1 (enExample) |
| HU (1) | HUE052981T2 (enExample) |
| IL (2) | IL246155A0 (enExample) |
| LT (1) | LT3079669T (enExample) |
| MX (2) | MX386584B (enExample) |
| NZ (2) | NZ721952A (enExample) |
| PE (2) | PE20211976A1 (enExample) |
| PH (1) | PH12016501122B1 (enExample) |
| PL (1) | PL3079669T3 (enExample) |
| PT (1) | PT3079669T (enExample) |
| RS (1) | RS61133B1 (enExample) |
| SG (2) | SG10201804817TA (enExample) |
| SI (1) | SI3079669T1 (enExample) |
| SM (1) | SMT202000686T1 (enExample) |
| UA (1) | UA119335C2 (enExample) |
| WO (2) | WO2015089335A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119335C2 (uk) * | 2013-12-11 | 2019-06-10 | Айронвуд Фармасьютикалз, Інк. | Композиції лінаклотиду з затриманим вивільненням |
| WO2016020901A1 (en) | 2014-08-07 | 2016-02-11 | Acerta Pharma B.V. | Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate |
| CA2902911C (en) | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| US20180008547A1 (en) * | 2015-02-02 | 2018-01-11 | Aurobindo Pharma Ltd | Stable Compositions comprising Linaclotide |
| EP3302440B1 (en) * | 2015-06-05 | 2021-01-06 | Ironwood Pharmaceuticals, Inc. | Modified or targeted release formulations of linaclotide |
| US10588864B2 (en) | 2016-03-11 | 2020-03-17 | Gateway Pharmaceuticals LLC | Pharmaceutical compositions for colon-specific delivery |
| WO2017156214A1 (en) * | 2016-03-11 | 2017-09-14 | Gateway Pharmaceutical LLC | Pharmaceutical compositions for colon-specific delivery |
| WO2018065826A1 (en) * | 2016-10-06 | 2018-04-12 | Sucampo Ag | Multilayer beads for pharmaceutical use |
| MA47112A (fr) * | 2016-12-21 | 2019-10-30 | Ironwood Pharmaceuticals Inc | Procédés de traitement du syndrome du côlon irritable avec des formulations à libération modifiée ou retardée de linaclotide |
| KR102227486B1 (ko) * | 2017-06-30 | 2021-03-12 | 롯데정밀화학 주식회사 | 프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법 |
| WO2019183472A1 (en) * | 2018-03-23 | 2019-09-26 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| US20220241367A1 (en) * | 2019-06-10 | 2022-08-04 | Ironwood Pharmaceutical, Inc. | Treatment of Abdominal Pain Associated with Diarrhea-Predominant Irritable Bowel Syndrome |
| KR102104507B1 (ko) * | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법 |
| CN110935007B (zh) * | 2019-12-12 | 2023-06-23 | 烟台大学 | 利那洛肽复方组合物、制剂及其用途和制备方法 |
| GB202017863D0 (en) * | 2020-11-12 | 2020-12-30 | Intract Pharma Ltd | Novel compositions |
| EP4340838A4 (en) * | 2021-05-19 | 2025-04-16 | Alberto Paz | ORALLY ADMINISTERED COMPOSITIONS FOR CANCER TREATMENT |
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| US7304036B2 (en) | 2003-01-28 | 2007-12-04 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
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| CN201252259Y (zh) * | 2008-07-24 | 2009-06-03 | 富士康(昆山)电脑接插件有限公司 | 电连接器 |
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| WO2011019819A1 (en) * | 2009-08-12 | 2011-02-17 | Forest Laboratories Holdings Limited | Orally disintegrating compositions of linaclotide |
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| US20130045239A1 (en) * | 2009-08-13 | 2013-02-21 | Ironwood Pharmaceuticals, Inc. | Method for Modulating the Pharmacodynamic Effect of Orally Administered Guanylate Cyclase Receptor Agonists |
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| EP2613794A1 (en) * | 2010-09-11 | 2013-07-17 | Ironwood Pharmaceuticals, Inc. | Treatment of constipation-predominant irritable bowel syndrome |
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| UA119335C2 (uk) | 2013-12-11 | 2019-06-10 | Айронвуд Фармасьютикалз, Інк. | Композиції лінаклотиду з затриманим вивільненням |
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