PE20170921A1 - Composiciones farmaceuticas de accion prolongada para la hepatitis c - Google Patents

Composiciones farmaceuticas de accion prolongada para la hepatitis c

Info

Publication number
PE20170921A1
PE20170921A1 PE2017000832A PE2017000832A PE20170921A1 PE 20170921 A1 PE20170921 A1 PE 20170921A1 PE 2017000832 A PE2017000832 A PE 2017000832A PE 2017000832 A PE2017000832 A PE 2017000832A PE 20170921 A1 PE20170921 A1 PE 20170921A1
Authority
PE
Peru
Prior art keywords
hepatitis
long
compound
pharmaceutical composition
pharmaceutical compositions
Prior art date
Application number
PE2017000832A
Other languages
English (en)
Inventor
Zhi Hong
Martin R Leivers
Original Assignee
Glaxosmithkline Intellectual Property (No 2) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54478190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20170921(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Intellectual Property (No 2) Ltd filed Critical Glaxosmithkline Intellectual Property (No 2) Ltd
Publication of PE20170921A1 publication Critical patent/PE20170921A1/es

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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se refiere a una composicion farmaceutica parenteral de liberacion prolongada (LAP) que comprende al compuesto 6-(N-(7-cloro-1-hidroxi-1,3-dihidrobenzo[c][1,2]oxaborol-5-il)metilsulfonamido-5-ciclopropil-2-(4-fluorofenil)-N-metilbenzofuran-3-carboxamida de formula I en combinacion con un compuesto de formulas IIA o IIB, donde R es un oligonucleotido anti-miR-122 en 5'-3' y el anillo A es cicloalquilo o heterociclilo. Ademas, comprende un sistema tensioactivo que comprende un tensioactivo tal como esteres de acidos grasos de polioxietileno sorbitan, poloxameros, entre otros; un estabilizador tal como polietilenglicoles, carboximetilcelulosa de calcio, entre otros y una sal tamponadora. Dicha composicion farmaceutica es util en el tratamiento de infecciones causadas por el virus de la hepatitis C (VHC)
PE2017000832A 2014-11-10 2015-10-30 Composiciones farmaceuticas de accion prolongada para la hepatitis c PE20170921A1 (es)

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180071276A (ko) * 2015-09-29 2018-06-27 얀센 파마슈티칼즈, 인코포레이티드 Hcv 치료를 위한 조합물 요법 투약법
CN109833480B (zh) * 2019-03-22 2021-09-07 中国科学院上海巴斯德研究所 靶向nk细胞免疫检查点治疗感染性疾病的方法
US20230285435A1 (en) * 2020-07-17 2023-09-14 The Regents Of The University Of California Compositions and methods for treating viral infections

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118800A (en) 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
FR2567892B1 (fr) 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
US5591722A (en) 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
ATE190981T1 (de) 1989-10-24 2000-04-15 Isis Pharmaceuticals Inc 2'-modifizierte nukleotide
US5646265A (en) 1990-01-11 1997-07-08 Isis Pharmceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
GB9009980D0 (en) 1990-05-03 1990-06-27 Amersham Int Plc Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
EP0455905B1 (en) 1990-05-11 1998-06-17 Microprobe Corporation Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides
DE59208572D1 (de) 1991-10-17 1997-07-10 Ciba Geigy Ag Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
US5359044A (en) 1991-12-13 1994-10-25 Isis Pharmaceuticals Cyclobutyl oligonucleotide surrogates
FR2687679B1 (fr) 1992-02-05 1994-10-28 Centre Nat Rech Scient Oligothionucleotides.
EP0577558A2 (de) 1992-07-01 1994-01-05 Ciba-Geigy Ag Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
AU6449394A (en) 1993-03-30 1994-10-24 Sterling Winthrop Inc. Acyclic nucleoside analogs and oligonucleotide sequences containing them
DE4311944A1 (de) 1993-04-10 1994-10-13 Degussa Umhüllte Natriumpercarbonatpartikel, Verfahren zu deren Herstellung und sie enthaltende Wasch-, Reinigungs- und Bleichmittelzusammensetzungen
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5627053A (en) 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5792747A (en) 1995-01-24 1998-08-11 The Administrators Of The Tulane Educational Fund Highly potent agonists of growth hormone releasing hormone
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
ES2242291T5 (es) 1997-09-12 2016-03-11 Exiqon A/S Análogos de nucleósidos bicíclicos y tricíclicos, nucleótidos y oligonucleótidos
TW200524915A (en) * 2003-09-26 2005-08-01 Tanabe Seiyaku Co Carbamoyl-type benzofuran derivatives
EP2500431A3 (en) 2004-05-04 2013-12-18 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for reducing viral genome amounts in a target cell
RU2453548C2 (ru) * 2006-01-17 2012-06-20 Вертекс Фармасьютикалз Инкорпорейтед Азаиндолы, полезные в качестве ингибиторов янус-киназ
WO2008041246A2 (en) * 2006-10-05 2008-04-10 Panacea Biotec Ltd. Injectable depot composition and its' process of preparation
AU2009234266B2 (en) 2008-04-11 2015-08-06 Tekmira Pharmaceuticals Corporation Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
UY32099A (es) * 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
CA2772579C (en) * 2009-09-10 2015-12-08 Youzhi Tong Thioimidazolidinone androgen receptor antagonists and uses thereof
US20130236968A1 (en) 2010-06-21 2013-09-12 Alnylam Pharmaceuticals, Inc. Multifunctional copolymers for nucleic acid delivery
US8445497B2 (en) * 2010-06-30 2013-05-21 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
JP6166721B2 (ja) * 2011-07-22 2017-07-19 ケモセントリックス， インコーポレイテッド ４−ｔｅｒｔ−ブチル−Ｎ−［４−クロロ−２−（１−オキシ−ピリジン−４−カルボニル）−フェニル］−ベンゼンスルホンアミドのナトリウム塩の多形
CN103929965B (zh) * 2011-08-17 2016-08-17 葛兰素史克有限责任公司 治疗方法
JP6367712B2 (ja) * 2011-08-19 2018-08-01 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｃ型肝炎ウイルス感染の治療のためのベンゾフラン化合物
EP2747569A4 (en) * 2011-08-24 2015-07-08 Glaxosmithkline Llc COMBINATION TREATMENTS FOR HEPATITIS C
WO2014118272A1 (en) * 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
SG11201508925WA (en) * 2013-05-01 2015-11-27 Regulus Therapeutics Inc Microrna compounds and methods for modulating mir-122
AU2015344741A1 (en) * 2014-11-10 2017-05-25 Glaxosmithkline Intellectual Property (No.2) Limited Combination long acting compositions and methods for hepatitis C

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