PE20152028A1 - Composiciones farmaceuticas - Google Patents

Composiciones farmaceuticas

Info

Publication number
PE20152028A1
PE20152028A1 PE2015002552A PE2015002552A PE20152028A1 PE 20152028 A1 PE20152028 A1 PE 20152028A1 PE 2015002552 A PE2015002552 A PE 2015002552A PE 2015002552 A PE2015002552 A PE 2015002552A PE 20152028 A1 PE20152028 A1 PE 20152028A1
Authority
PE
Peru
Prior art keywords
phenyl
formula
pharmaceutical compositions
propanamide
triazolo
Prior art date
Application number
PE2015002552A
Other languages
English (en)
Inventor
Michael Bruning
Detlef Stockigt
Volker Schulze
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48569985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20152028(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of PE20152028A1 publication Critical patent/PE20152028A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Referida a una composicion farmaceutica que comprende un compuesto derivado de triazolopiridina sustituida de formula general (I), donde: R1 es la formula a); R2 es la formula b); R3, R4 y R5 son H; R5a es alcoxi C1-C4, etc; R5b ES -C(=O)NHR8, etc; R6 es la formula c); R9 es alquilo C1-C3. Son compuestos preferidos: (2R)-2-(4-fluorofenil)-N-[4-(2-{[2-metoxi-4-(metilsulfonil)fenil]amino}[1,2,4]triazolo[1,5-a]piridin-6-il)fenil]propanamida, (2R)-N-[4-(2-{[2-etoxi-4-(metilsulfonil)fenil]amino}[1,2,4]triazolo[1,5-a]piridin-6-il)fenil]-2-(4-fluorofenil)propanamida, entre otros.
PE2015002552A 2013-06-06 2014-06-05 Composiciones farmaceuticas PE20152028A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13170754 2013-06-06

Publications (1)

Publication Number Publication Date
PE20152028A1 true PE20152028A1 (es) 2016-02-07

Family

ID=48569985

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015002552A PE20152028A1 (es) 2013-06-06 2014-06-05 Composiciones farmaceuticas

Country Status (35)

Country Link
US (1) US20160120854A1 (es)
EP (1) EP3003381B1 (es)
JP (1) JP2016523229A (es)
KR (1) KR20160018513A (es)
CN (1) CN105263526A (es)
AP (1) AP2015008890A0 (es)
AR (1) AR096469A1 (es)
AU (1) AU2014276870A1 (es)
BR (1) BR112015030292A2 (es)
CA (1) CA2914439A1 (es)
CL (1) CL2015003535A1 (es)
CR (1) CR20150641U (es)
CU (1) CU24283B1 (es)
CY (1) CY1119666T1 (es)
DK (1) DK3003381T3 (es)
DO (1) DOP2015000295A (es)
EA (1) EA201501177A1 (es)
ES (1) ES2652149T3 (es)
HK (1) HK1219906A1 (es)
HR (1) HRP20171888T1 (es)
HU (1) HUE034883T2 (es)
LT (1) LT3003381T (es)
MA (1) MA38642A1 (es)
NI (1) NI201500172A (es)
NO (1) NO3003381T3 (es)
PE (1) PE20152028A1 (es)
PH (1) PH12015502703A1 (es)
PL (1) PL3003381T3 (es)
PT (1) PT3003381T (es)
RS (1) RS56666B1 (es)
SG (1) SG11201509114TA (es)
SI (1) SI3003381T1 (es)
TN (1) TN2015000524A1 (es)
UY (1) UY35600A (es)
WO (1) WO2014195408A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105377848A (zh) * 2013-06-11 2016-03-02 拜耳制药股份公司 取代的三唑并吡啶的前体药物衍生物
TW201800408A (zh) 2016-06-15 2018-01-01 拜耳製藥公司 Mps-1抑制劑

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030212102A1 (en) * 2001-06-12 2003-11-13 Koretke Todd W Novel solid dispersion compositions
WO2006026501A1 (en) * 2004-08-27 2006-03-09 Bayer Pharmaceuticals Corporation New pharmaceutical compositions for the treatment of cancer
CN101125124B (zh) * 2006-08-16 2011-04-20 沈阳药科大学 一种亲脂性药物固体分散体的制备方法
EP2343295A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
EP2343294A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
UA112096C2 (uk) * 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
CN102512358B (zh) * 2011-12-16 2013-04-10 南京农业大学 家畜用利福昔明阴道栓剂及其制备方法
CN102626384A (zh) * 2012-04-12 2012-08-08 临沂大学 一种姜黄素混悬剂及其制备方法

Also Published As

Publication number Publication date
CR20150641U (es) 2016-01-29
SG11201509114TA (en) 2015-12-30
WO2014195408A1 (en) 2014-12-11
PT3003381T (pt) 2017-12-20
CL2015003535A1 (es) 2016-07-08
SI3003381T1 (en) 2018-01-31
HUE034883T2 (hu) 2018-03-28
ES2652149T3 (es) 2018-01-31
KR20160018513A (ko) 2016-02-17
NO3003381T3 (es) 2018-02-10
CY1119666T1 (el) 2018-04-04
AU2014276870A1 (en) 2015-11-19
CA2914439A1 (en) 2014-12-11
AR096469A1 (es) 2015-12-30
EP3003381A1 (en) 2016-04-13
CU24283B1 (es) 2017-11-07
US20160120854A1 (en) 2016-05-05
CN105263526A (zh) 2016-01-20
NI201500172A (es) 2016-01-06
EP3003381B1 (en) 2017-09-13
AP2015008890A0 (en) 2015-11-30
UY35600A (es) 2015-01-30
LT3003381T (lt) 2017-12-27
DOP2015000295A (es) 2016-03-15
DK3003381T3 (en) 2017-12-11
PH12015502703A1 (en) 2016-03-14
JP2016523229A (ja) 2016-08-08
PL3003381T3 (pl) 2018-02-28
EA201501177A1 (ru) 2016-06-30
CU20150170A7 (es) 2016-03-31
RS56666B1 (sr) 2018-03-30
MA38642A1 (fr) 2017-10-31
TN2015000524A1 (en) 2017-04-06
HK1219906A1 (zh) 2017-04-21
HRP20171888T1 (hr) 2018-01-12
BR112015030292A2 (pt) 2017-07-25

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