PE20091087A1 - COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO COMO INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K - Google Patents

COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO COMO INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K

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Publication number
PE20091087A1
PE20091087A1 PE2008001179A PE2008001179A PE20091087A1 PE 20091087 A1 PE20091087 A1 PE 20091087A1 PE 2008001179 A PE2008001179 A PE 2008001179A PE 2008001179 A PE2008001179 A PE 2008001179A PE 20091087 A1 PE20091087 A1 PE 20091087A1
Authority
PE
Peru
Prior art keywords
catepsin
carbonitrile
imidazo
pyridine
phenyl
Prior art date
Application number
PE2008001179A
Other languages
English (en)
Inventor
Zoran Rankovic
Philip Stephen Jones
David Jonathan Bennett
Jiaqiang Cai
Xavier Fradera
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of PE20091087A1 publication Critical patent/PE20091087A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H O ALQUILO(C1-C3); R3 ES HALOGENO o ALQUILO (C1-C4) OPCIONALMENTE SUSTITUIDO POR UNO o MAS HALOGENOS; R4 ES H, HALOGENO o CN; X ES C2, O o S; Y ES OH, CN, ALQUILO(C1-C3)CARBONILO, ENTRE OTROS, n ES DE 1-5. SON COMPUESTOS PREFERIDOS: 6-[4-(3-DIMETILAMINOPROPOXI)-3-(TRIFLUOROMETIL)-FENIL]-1-METIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO; 1-METIL-6-[4-(3-PIRROLIDIN-1-ILPROPOXI)-3-(TRIFLUOROMETIL)-FENIL]-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO, 6-[4-(3-N,N-DIETILAMINO-PROPOXI)-3-(TRIFLUOROMETIL)-FENIL]-1-METIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K SIENDO UTILES PARA EL TRATMIENTO DE OSTEOPOROSIS, ATEROESCLEROSIS, ARTRITIS REUMATODE, ENTRE OTROS
PE2008001179A 2007-07-16 2008-07-14 COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO COMO INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K PE20091087A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07112517 2007-07-16

Publications (1)

Publication Number Publication Date
PE20091087A1 true PE20091087A1 (es) 2009-07-20

Family

ID=38846911

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001179A PE20091087A1 (es) 2007-07-16 2008-07-14 COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO COMO INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K

Country Status (20)

Country Link
EP (1) EP2178873B1 (es)
JP (1) JP5371976B2 (es)
KR (1) KR20100043235A (es)
CN (1) CN101842373B (es)
AR (1) AR067530A1 (es)
AT (1) ATE492546T1 (es)
AU (1) AU2008277679B2 (es)
BR (1) BRPI0813587A2 (es)
CA (1) CA2693887A1 (es)
CL (1) CL2008002082A1 (es)
DE (1) DE602008004167D1 (es)
EC (1) ECSP109966A (es)
ES (1) ES2356279T3 (es)
HK (1) HK1142323A1 (es)
IL (1) IL202769A0 (es)
PE (1) PE20091087A1 (es)
RU (1) RU2485119C2 (es)
TW (1) TW200911803A (es)
WO (1) WO2009010491A1 (es)
ZA (1) ZA200909132B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932251B2 (en) 2007-07-16 2011-04-26 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
TW201035094A (en) * 2009-01-16 2010-10-01 Organon Nv 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
US8026236B2 (en) 2009-01-16 2011-09-27 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
WO2011086125A1 (en) 2010-01-15 2011-07-21 N.V. Organon 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES
WO2013018733A1 (ja) 2011-07-29 2013-02-07 富士フイルム株式会社 1,5-ナフチリジン誘導体又はその塩
EP2840083B1 (en) * 2012-04-17 2017-09-13 Astellas Pharma Inc. Nitrogenated bicyclic aromatic heterocyclic compound
WO2020201572A1 (en) 2019-04-05 2020-10-08 Université De Bretagne Occidentale Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning
MX2022008875A (es) 2020-01-20 2022-08-11 Genzyme Corp Inhibidores terapeuticos de tirosina quinasa para esclerosis multiple recidivante (emr).
EP3858471A1 (en) 2020-01-31 2021-08-04 Novamem AG Solvent-free production of porous polymer structures
JP2023553930A (ja) 2020-12-10 2023-12-26 ジェンザイム・コーポレーション トレブルチニブの結晶形態、その製造方法、およびその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA62972C2 (en) * 1997-07-03 2004-01-15 Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders
GB9921150D0 (en) * 1999-09-07 1999-11-10 Merck Sharp & Dohme Therapeutic agents
PA8535601A1 (es) * 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
GB0121033D0 (en) * 2001-08-30 2001-10-24 Novartis Ag Organic compounds
SE0201980D0 (sv) * 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
FR2852957B1 (fr) * 2003-03-31 2005-06-10 Sod Conseils Rech Applic Nouveaux derives d'imidazo-pyridine et leur utilisation en tant que medicament
JPWO2005085210A1 (ja) * 2004-03-10 2008-01-17 小野薬品工業株式会社 ニトリル化合物およびその化合物を有効成分として含有する医薬組成物
TW200734338A (en) * 2006-01-16 2007-09-16 Organon Nv 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives

Also Published As

Publication number Publication date
JP5371976B2 (ja) 2013-12-18
IL202769A0 (en) 2010-06-30
AU2008277679A1 (en) 2009-01-22
EP2178873A1 (en) 2010-04-28
ZA200909132B (en) 2010-08-25
ES2356279T3 (es) 2011-04-06
ATE492546T1 (de) 2011-01-15
JP2010533675A (ja) 2010-10-28
KR20100043235A (ko) 2010-04-28
RU2485119C2 (ru) 2013-06-20
CL2008002082A1 (es) 2009-01-02
HK1142323A1 (en) 2010-12-03
CA2693887A1 (en) 2009-01-22
CN101842373A (zh) 2010-09-22
ECSP109966A (es) 2010-03-31
AR067530A1 (es) 2009-10-14
EP2178873B1 (en) 2010-12-22
RU2010105234A (ru) 2011-08-27
CN101842373B (zh) 2013-12-18
DE602008004167D1 (en) 2011-02-03
TW200911803A (en) 2009-03-16
AU2008277679B2 (en) 2012-11-15
BRPI0813587A2 (pt) 2014-12-30
WO2009010491A1 (en) 2009-01-22

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