PE20091087A1 - COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO COMO INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K - Google Patents
COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO COMO INHIBIDORES DE CATEPSINA S Y/O CATEPSINA KInfo
- Publication number
- PE20091087A1 PE20091087A1 PE2008001179A PE2008001179A PE20091087A1 PE 20091087 A1 PE20091087 A1 PE 20091087A1 PE 2008001179 A PE2008001179 A PE 2008001179A PE 2008001179 A PE2008001179 A PE 2008001179A PE 20091087 A1 PE20091087 A1 PE 20091087A1
- Authority
- PE
- Peru
- Prior art keywords
- catepsin
- carbonitrile
- imidazo
- pyridine
- phenyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H O ALQUILO(C1-C3); R3 ES HALOGENO o ALQUILO (C1-C4) OPCIONALMENTE SUSTITUIDO POR UNO o MAS HALOGENOS; R4 ES H, HALOGENO o CN; X ES C2, O o S; Y ES OH, CN, ALQUILO(C1-C3)CARBONILO, ENTRE OTROS, n ES DE 1-5. SON COMPUESTOS PREFERIDOS: 6-[4-(3-DIMETILAMINOPROPOXI)-3-(TRIFLUOROMETIL)-FENIL]-1-METIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO; 1-METIL-6-[4-(3-PIRROLIDIN-1-ILPROPOXI)-3-(TRIFLUOROMETIL)-FENIL]-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO, 6-[4-(3-N,N-DIETILAMINO-PROPOXI)-3-(TRIFLUOROMETIL)-FENIL]-1-METIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K SIENDO UTILES PARA EL TRATMIENTO DE OSTEOPOROSIS, ATEROESCLEROSIS, ARTRITIS REUMATODE, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07112517 | 2007-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091087A1 true PE20091087A1 (es) | 2009-07-20 |
Family
ID=38846911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001179A PE20091087A1 (es) | 2007-07-16 | 2008-07-14 | COMPUESTOS DERIVADOS DE 6-FENIL-1H-IMIDAZO[4,5-c]PIRIDINA-4-CARBONITRILO COMO INHIBIDORES DE CATEPSINA S Y/O CATEPSINA K |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP2178873B1 (es) |
JP (1) | JP5371976B2 (es) |
KR (1) | KR20100043235A (es) |
CN (1) | CN101842373B (es) |
AR (1) | AR067530A1 (es) |
AT (1) | ATE492546T1 (es) |
AU (1) | AU2008277679B2 (es) |
BR (1) | BRPI0813587A2 (es) |
CA (1) | CA2693887A1 (es) |
CL (1) | CL2008002082A1 (es) |
DE (1) | DE602008004167D1 (es) |
EC (1) | ECSP109966A (es) |
ES (1) | ES2356279T3 (es) |
HK (1) | HK1142323A1 (es) |
IL (1) | IL202769A0 (es) |
PE (1) | PE20091087A1 (es) |
RU (1) | RU2485119C2 (es) |
TW (1) | TW200911803A (es) |
WO (1) | WO2009010491A1 (es) |
ZA (1) | ZA200909132B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7932251B2 (en) | 2007-07-16 | 2011-04-26 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
TW201035094A (en) * | 2009-01-16 | 2010-10-01 | Organon Nv | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
US8026236B2 (en) | 2009-01-16 | 2011-09-27 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
WO2011086125A1 (en) | 2010-01-15 | 2011-07-21 | N.V. Organon | 1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES |
WO2013018733A1 (ja) | 2011-07-29 | 2013-02-07 | 富士フイルム株式会社 | 1,5-ナフチリジン誘導体又はその塩 |
EP2840083B1 (en) * | 2012-04-17 | 2017-09-13 | Astellas Pharma Inc. | Nitrogenated bicyclic aromatic heterocyclic compound |
WO2020201572A1 (en) | 2019-04-05 | 2020-10-08 | Université De Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
MX2022008875A (es) | 2020-01-20 | 2022-08-11 | Genzyme Corp | Inhibidores terapeuticos de tirosina quinasa para esclerosis multiple recidivante (emr). |
EP3858471A1 (en) | 2020-01-31 | 2021-08-04 | Novamem AG | Solvent-free production of porous polymer structures |
JP2023553930A (ja) | 2020-12-10 | 2023-12-26 | ジェンザイム・コーポレーション | トレブルチニブの結晶形態、その製造方法、およびその使用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA62972C2 (en) * | 1997-07-03 | 2004-01-15 | Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders | |
GB9921150D0 (en) * | 1999-09-07 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
GB0121033D0 (en) * | 2001-08-30 | 2001-10-24 | Novartis Ag | Organic compounds |
SE0201980D0 (sv) * | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
FR2852957B1 (fr) * | 2003-03-31 | 2005-06-10 | Sod Conseils Rech Applic | Nouveaux derives d'imidazo-pyridine et leur utilisation en tant que medicament |
JPWO2005085210A1 (ja) * | 2004-03-10 | 2008-01-17 | 小野薬品工業株式会社 | ニトリル化合物およびその化合物を有効成分として含有する医薬組成物 |
TW200734338A (en) * | 2006-01-16 | 2007-09-16 | Organon Nv | 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives |
-
2008
- 2008-06-18 TW TW097122685A patent/TW200911803A/zh unknown
- 2008-07-14 JP JP2010516481A patent/JP5371976B2/ja not_active Expired - Fee Related
- 2008-07-14 BR BRPI0813587-8A2A patent/BRPI0813587A2/pt not_active Application Discontinuation
- 2008-07-14 ES ES08786128T patent/ES2356279T3/es active Active
- 2008-07-14 CN CN200880024871XA patent/CN101842373B/zh not_active Expired - Fee Related
- 2008-07-14 RU RU2010105234/04A patent/RU2485119C2/ru not_active IP Right Cessation
- 2008-07-14 DE DE602008004167T patent/DE602008004167D1/de active Active
- 2008-07-14 EP EP08786128A patent/EP2178873B1/en active Active
- 2008-07-14 AR ARP080103015A patent/AR067530A1/es unknown
- 2008-07-14 KR KR1020107003287A patent/KR20100043235A/ko not_active Application Discontinuation
- 2008-07-14 PE PE2008001179A patent/PE20091087A1/es not_active Application Discontinuation
- 2008-07-14 AT AT08786128T patent/ATE492546T1/de not_active IP Right Cessation
- 2008-07-14 CA CA2693887A patent/CA2693887A1/en not_active Abandoned
- 2008-07-14 WO PCT/EP2008/059172 patent/WO2009010491A1/en active Application Filing
- 2008-07-14 AU AU2008277679A patent/AU2008277679B2/en not_active Ceased
- 2008-07-15 CL CL2008002082A patent/CL2008002082A1/es unknown
-
2009
- 2009-12-16 IL IL202769A patent/IL202769A0/en unknown
- 2009-12-21 ZA ZA200909132A patent/ZA200909132B/xx unknown
-
2010
- 2010-02-12 EC EC2010009966A patent/ECSP109966A/es unknown
- 2010-09-16 HK HK10108808.3A patent/HK1142323A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5371976B2 (ja) | 2013-12-18 |
IL202769A0 (en) | 2010-06-30 |
AU2008277679A1 (en) | 2009-01-22 |
EP2178873A1 (en) | 2010-04-28 |
ZA200909132B (en) | 2010-08-25 |
ES2356279T3 (es) | 2011-04-06 |
ATE492546T1 (de) | 2011-01-15 |
JP2010533675A (ja) | 2010-10-28 |
KR20100043235A (ko) | 2010-04-28 |
RU2485119C2 (ru) | 2013-06-20 |
CL2008002082A1 (es) | 2009-01-02 |
HK1142323A1 (en) | 2010-12-03 |
CA2693887A1 (en) | 2009-01-22 |
CN101842373A (zh) | 2010-09-22 |
ECSP109966A (es) | 2010-03-31 |
AR067530A1 (es) | 2009-10-14 |
EP2178873B1 (en) | 2010-12-22 |
RU2010105234A (ru) | 2011-08-27 |
CN101842373B (zh) | 2013-12-18 |
DE602008004167D1 (en) | 2011-02-03 |
TW200911803A (en) | 2009-03-16 |
AU2008277679B2 (en) | 2012-11-15 |
BRPI0813587A2 (pt) | 2014-12-30 |
WO2009010491A1 (en) | 2009-01-22 |
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