PE20090739A1 - Derivados de fenilcondensados con actividad sobre el colageno - Google Patents
Derivados de fenilcondensados con actividad sobre el colagenoInfo
- Publication number
- PE20090739A1 PE20090739A1 PE2008001140A PE2008001140A PE20090739A1 PE 20090739 A1 PE20090739 A1 PE 20090739A1 PE 2008001140 A PE2008001140 A PE 2008001140A PE 2008001140 A PE2008001140 A PE 2008001140A PE 20090739 A1 PE20090739 A1 PE 20090739A1
- Authority
- PE
- Peru
- Prior art keywords
- benzoxazole
- fluor
- vinyl
- alkyl
- reduction
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A COMPUESTOS ESTROGENICOS DERIVADOS DE FORMULA I, COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN DICHOS COMPUESTOS, METODOS PARA LA PREVENCION, TRATAMIENTO, O INHIBICION DE ENFERMEDADES, TRASTORNOS, O AFECCIONES ASOCIADOS CON LA DISMINUCION DE COLAGENO, TAL COMO FOTOENVEJECIMIENTO, ENVEJECIMIENTO CUTANEO CRONOLOGICO, DERMATITIS, PSORIASIS, ENTRE OTROS. ASIMISMO, LOS COMPUESTOS ESTROGENICOS DE LA PRESENTE INVENCION SUPRIMEN LA ACTIVIDAD DE MMP1, IL1B, Y/O IL8. DONDE Q1 Y Q2 SON H, UN RESTO DE AZUCAR SELECCIONADO DE UN RESIDUO DE HEXOSA NO MODIFICADO O MODIFICADO, O S(O)t-OH, SIEMPRE QUE Q1 Y Q2 NO SEAN AMBOS H; t ES 0, 1 O 2; R1 ES ALQUENILO C2-C7, SUSTITUIDO OPCIONALMENTE CON OH, -CN, HALOGENO, TRIFLUOROALQUILO C1-C6, ENTRE OTROS; R2 Y R2a SON H, OH, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; R3 Y R3a SON H, ALQUILO C1-6, ALQUENILO C2-C7, ALQUINILO C2-C7, ENTRE OTROS; X ES O, S, O NR7; R7 ES H, ALQUILO C1-C6, ARILO C6-C10, ENTRE OTROS. EN ALGUNAS REALIZACIONES EL COMPUESTO DE FORMULA I ESTA SELECCIONADO DE 2-(GLUCURONIDO 3'-FLUOR-4'-FENIL)-7-VINIL-1,3-BENZOXAZOL-5-OL; 2-(SULFATO 3'-FLUOR-4'-FENIL)-7-VINIL-1,3-BENZOXAZOL-5-OL; 2-(3'-FLUOR-4'-HIDROXIFENIL)-7-VINIL-1,3-BENZOXAZOL-5-GLUCORONICO; 2-(3'-FLUOR-4'-HIDROXIFENIL)-7-VINIL-1,3-BENZOXAZOL-5-SULFATO; ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94824807P | 2007-07-06 | 2007-07-06 | |
US95095107P | 2007-07-20 | 2007-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090739A1 true PE20090739A1 (es) | 2009-07-17 |
Family
ID=39736935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001140A PE20090739A1 (es) | 2007-07-06 | 2008-07-07 | Derivados de fenilcondensados con actividad sobre el colageno |
Country Status (6)
Country | Link |
---|---|
US (1) | US20090010884A1 (es) |
AR (1) | AR067452A1 (es) |
CL (1) | CL2008001985A1 (es) |
PE (1) | PE20090739A1 (es) |
TW (1) | TW200908960A (es) |
WO (1) | WO2009009417A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US9044477B2 (en) * | 2007-12-12 | 2015-06-02 | Allergan, Inc. | Botulinum toxin formulation |
WO2011022721A1 (en) * | 2009-08-21 | 2011-02-24 | Microbiotix, Inc | Inhibitors of botulinum neurotoxins |
WO2011041483A2 (en) * | 2009-09-30 | 2011-04-07 | Toxcure, Inc. | Use of botulinum neurotoxin to treat substance addictions |
CN103242273B (zh) * | 2012-02-09 | 2015-06-03 | 中国科学院上海药物研究所 | 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途 |
CN104327088A (zh) * | 2014-09-24 | 2015-02-04 | 大连理工大学 | 一种7-氯-6H-苯并吡喃[4,3-b]喹啉及其衍生物的制备方法 |
CN104262357B (zh) * | 2014-09-24 | 2017-05-03 | 大连理工大学 | 一种7‑氯‑6H‑苯并噻喃[4,3‑b]喹啉及其衍生物的制备方法 |
CN104292243A (zh) * | 2014-09-24 | 2015-01-21 | 大连理工大学 | 一种苯并噻喃[4,3-b]喹啉及其衍生物的制备方法 |
MX2019005833A (es) | 2016-11-21 | 2019-10-30 | Eirion Therapeutics Inc | Administracion transdermica de agentes grandes. |
WO2022123336A1 (en) * | 2020-12-07 | 2022-06-16 | Subramanya Gopal Hegde | Chromeno [4,3-b] quinoline compounds and their synthesis by using silicotungstic acid [h4siw12o40] |
CN116143741A (zh) * | 2023-03-07 | 2023-05-23 | 中国林业科学研究院林产化学工业研究所 | 一种具有抑菌活性的漆酚二聚体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6093706A (en) * | 1992-03-04 | 2000-07-25 | Bioresponse, L.L.C. | Combined dehydroepiandrosterone and retinoid therapy for epithelial disorders |
UA83620C2 (ru) * | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
US6903238B2 (en) * | 2001-12-13 | 2005-06-07 | Wyeth | Substituted indenones as estrogenic agents |
PE20060503A1 (es) * | 2004-08-26 | 2006-07-20 | Wyeth Corp | Prodroga de benzoxazoles substituidos como agentes estrogenicos |
BRPI0608689A2 (pt) * | 2005-03-08 | 2010-01-19 | Wyeth Corp | composto, composiÇço, processos para preparar monoidrato e a forma de cristal, e, uso de um monoidrato ou de uma forma de cristal |
AR064030A1 (es) * | 2006-11-30 | 2009-03-04 | Wyeth Corp | Proceso para la sintesis de derivados monosulfatados de benzoxazoles sustituidos |
-
2008
- 2008-07-03 US US12/167,850 patent/US20090010884A1/en not_active Abandoned
- 2008-07-03 WO PCT/US2008/069146 patent/WO2009009417A2/en active Application Filing
- 2008-07-04 AR ARP080102906A patent/AR067452A1/es unknown
- 2008-07-04 CL CL2008001985A patent/CL2008001985A1/es unknown
- 2008-07-04 TW TW097125249A patent/TW200908960A/zh unknown
- 2008-07-07 PE PE2008001140A patent/PE20090739A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20090010884A1 (en) | 2009-01-08 |
WO2009009417A3 (en) | 2009-07-02 |
AR067452A1 (es) | 2009-10-14 |
WO2009009417A2 (en) | 2009-01-15 |
CL2008001985A1 (es) | 2008-11-03 |
TW200908960A (en) | 2009-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |