WO2008073451A3 - Benzoimidazole derivatives as sirtuin (sir) modulating compounds - Google Patents

Benzoimidazole derivatives as sirtuin (sir) modulating compounds Download PDF

Info

Publication number
WO2008073451A3
WO2008073451A3 PCT/US2007/025391 US2007025391W WO2008073451A3 WO 2008073451 A3 WO2008073451 A3 WO 2008073451A3 US 2007025391 W US2007025391 W US 2007025391W WO 2008073451 A3 WO2008073451 A3 WO 2008073451A3
Authority
WO
WIPO (PCT)
Prior art keywords
sirtuin
diseases
disorders
modulating compounds
heteroaryl
Prior art date
Application number
PCT/US2007/025391
Other languages
French (fr)
Other versions
WO2008073451A8 (en
WO2008073451A2 (en
Inventor
Jean Bemis
Chi B Vu
Joseph J Nunes
David Armistead
Original Assignee
Sirtris Pharmaceuticals Inc
Jean Bemis
Chi B Vu
Joseph J Nunes
David Armistead
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc, Jean Bemis, Chi B Vu, Joseph J Nunes, David Armistead filed Critical Sirtris Pharmaceuticals Inc
Publication of WO2008073451A2 publication Critical patent/WO2008073451A2/en
Publication of WO2008073451A3 publication Critical patent/WO2008073451A3/en
Publication of WO2008073451A8 publication Critical patent/WO2008073451A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

A. Provided herein are novel sirtuin-modulating compounds of formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent ( I ), wherein: one of R1 R2 R3 or R4 is selected from a 5- to 6-membered heteroaryl comprising 1 to 3 heteroatoms 'independently selected from N, O or S, wherein said heteroaryl is optionally benzofused or optionally fused to a second 5- to 6-membered heteroaryl comprising 1 to 3 heteroatoms independently selected from N, O or S and is bound to the rest of the compound via a carbon ring atom, wherein said heteroaryl is optionally substituted on a single carbon ring atom with a substituent selected from a solubilizing group, or a C1-C4 straight or branched alkyl.
PCT/US2007/025391 2006-12-11 2007-12-11 Benzoimidazole derivatives as sirtuin (sir) modulating compounds WO2008073451A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87433406P 2006-12-11 2006-12-11
US60/874,334 2006-12-11

Publications (3)

Publication Number Publication Date
WO2008073451A2 WO2008073451A2 (en) 2008-06-19
WO2008073451A3 true WO2008073451A3 (en) 2008-09-12
WO2008073451A8 WO2008073451A8 (en) 2008-12-11

Family

ID=39512327

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/025391 WO2008073451A2 (en) 2006-12-11 2007-12-11 Benzoimidazole derivatives as sirtuin (sir) modulating compounds

Country Status (1)

Country Link
WO (1) WO2008073451A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2599987A1 (en) 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
EP2214698A2 (en) * 2007-10-23 2010-08-11 President and Fellows of Harvard College Use of compounds activating sirt-3 for mimicking exercise
WO2009084543A1 (en) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. Nitrogen-containing heterocyclic derivative and organic electroluminescent device using the same
US8685970B2 (en) 2008-05-01 2014-04-01 GlaxoSmithKline, LLC Quinolines and related analogs as sirtuin modulators
BRPI0914006A2 (en) 2008-07-03 2015-10-27 Sirtris Pharmaceuticals Inc benzimidazoles and related analogues as sirtuin modulators
RU2011109190A (en) * 2008-08-12 2012-09-20 Сертрис Фармасьютикалз, Инк. (Us) BENZOXAZOLE, BENZTHIAZOLE AND RELATED ANALOGUES AS SIRTUIN MODULATORS
KR101679089B1 (en) 2008-09-29 2016-11-23 서트리스 파마슈티컬즈, 인코포레이티드 Chromenone analogs as sirtuin modulators
WO2010054382A1 (en) * 2008-11-10 2010-05-14 Elixir Pharmaceuticals, Inc. Compounds, compositions, and methods for treating malaria or leishmaniasis
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
WO2010071853A1 (en) 2008-12-19 2010-06-24 Sirtris Pharmaceuticals, Inc. Thiazolopyridine sirtuin modulating compounds
AU2010233917B2 (en) * 2009-04-02 2015-07-02 Merck Serono S.A. Dihydroorotate dehydrogenase inhibitors
ES2484169T3 (en) * 2009-05-29 2014-08-11 Sumitomo Chemical Company, Limited Agent for the treatment or prevention of diseases associated with the activity of neurotrophic factors
KR20120092141A (en) 2009-10-29 2012-08-20 서트리스 파마슈티컬즈, 인코포레이티드 Bicyclic pyridines and analogs as sirtuin modulators
CA2801274C (en) 2010-06-01 2021-06-15 Summit Corporation Plc Compounds for the treatment of clostridium difficile-associated disease
GB2480815A (en) * 2010-06-01 2011-12-07 Summit Corp Plc Compounds for the treatment of clostridium difficile-associated disease
US8829200B2 (en) * 2010-10-29 2014-09-09 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9351973B2 (en) 2011-09-22 2016-05-31 Merck Sharp & Dohme Corp. Pyrazolopyridyl compounds as aldosterone synthase inhibitors
EP2757882B1 (en) 2011-09-22 2020-11-04 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
EP2757883B1 (en) 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
WO2014055595A1 (en) 2012-10-05 2014-04-10 Merck Sharp & Dohme Corp. Indoline compounds as aldosterone synthase inhibitiors related applications
US9246108B2 (en) 2012-12-28 2016-01-26 Dow Global Technologies Llc Quinoline-benzoxazole derived compounds for electronic films and devices
WO2018013776A1 (en) 2016-07-14 2018-01-18 Bristol-Myers Squibb Company Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors
JP6990228B2 (en) 2016-07-14 2022-01-13 ブリストル－マイヤーズ スクイブ カンパニー Bicyclic heteroaryl substituted compound
US11384081B2 (en) 2016-09-20 2022-07-12 Centre Leon Berard Benzoimidazole derivatives as anticancer agents

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004776A1 (en) * 1995-07-28 1997-02-13 The Inner And Eastern Health Care Network Radioprotectors
WO1999033824A1 (en) * 1997-12-31 1999-07-08 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
WO2003074516A1 (en) * 2002-03-06 2003-09-12 Oxford Glycosciences (Uk) Ltd Phthalimide carboxylic acid derivatives
EP1460067A1 (en) * 2001-11-26 2004-09-22 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
WO2006113458A1 (en) * 2005-04-15 2006-10-26 Bristol-Myers Squibb Company Heterocyclic inhibitors of protein arginine methyl transferases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004776A1 (en) * 1995-07-28 1997-02-13 The Inner And Eastern Health Care Network Radioprotectors
WO1999033824A1 (en) * 1997-12-31 1999-07-08 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
EP1460067A1 (en) * 2001-11-26 2004-09-22 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
WO2003074516A1 (en) * 2002-03-06 2003-09-12 Oxford Glycosciences (Uk) Ltd Phthalimide carboxylic acid derivatives
WO2006113458A1 (en) * 2005-04-15 2006-10-26 Bristol-Myers Squibb Company Heterocyclic inhibitors of protein arginine methyl transferases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUANG ET AL: "Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 14, no. 17, 1 September 2006 (2006-09-01), pages 6106 - 6119, XP005570395, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
WO2008073451A8 (en) 2008-12-11
WO2008073451A2 (en) 2008-06-19

Similar Documents

Publication Publication Date Title
WO2008073451A8 (en) Benzoimidazole derivatives as sirtuin (sir) modulating compounds
MX2010004965A (en) Amide derivatives as sirtuin modulators.
WO2009063202A3 (en) Use of crth2 antagonist compounds
WO2006094209A3 (en) N-benzimidazolylalkyl-substituted amide sirtuin modulators
WO2007019344A8 (en) Imidazo [2,1-b] thiazole derivatives as sirtuin modulating compounds
MX2011006555A (en) Thiazolopyridine sirtuin modulating compounds.
ATE537830T1 (en) NICOTINAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTICS
MY149316A (en) Sirtuin modulating imidazohiazole compounds
WO2005075425A3 (en) Substituted bisarylurea derivatives as kinase inhibitors
DK1780197T3 (en) 5-Substituted 2-phenylamino-benzamides as MEK inhibitors
MX2010005186A (en) Solubilized thiazolopyridines.
BRPI0513433A (en) hydantoin derivatives for the treatment of inflammatory disorders
NO20060981L (en) Pyridazine derivatives and their use as therapeutic agents
EA200802223A1 (en) 1,5-DIPHENYLPYRAZOLES II AS HSP90 INHIBITORS
WO2007046867A3 (en) Piperidine derivatives and their uses as therapeutic agents
WO2006094210A3 (en) Tetrahydroquinoxalinone sirtuin modulators
NO20072389L (en) Substituted benzoquinoline derivatives
ATE307810T1 (en) IMIDAZOLE-2-CARBONIC ACID AMIDE DERIVATIVES AS RAF-KINASE INHIBITORS
DE502005001315D1 (en) HETEROCYCLICALLY SUBSTITUTED 7-AMINO-4-CHINOLONE-3-CARBOXYLIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS
WO2007006534A3 (en) Piperidine derivatives useful in the diagnostic and therapeutic treatment of diseases depending on renin activity
WO2004046122A3 (en) Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
DE502005008351D1 (en) CHINOLINE DERIVATIVE, THEIR USE, MANUFACTURE AND MEDICAMENT CONTAINING THEREOF
DE502005003310D1 (en) CYCLOALKYL SUBSTITUTED 7-AMINO-4-CHINOLONE-3-CARBOXYLIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICAMENT
DE602006014022D1 (en) 5-SUBSTITUTED INDOL-2-CARBOXYL ACID AMID DERIVATIVES
DE60335404D1 (en) USE OF 4-AMINOCHINOLIN COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY ILLNESSES OF THE EYE

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07862800

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 07862800

Country of ref document: EP

Kind code of ref document: A2