PE20090704A1 - Derivados heterociclicos triciclicos - Google Patents
Derivados heterociclicos triciclicosInfo
- Publication number
- PE20090704A1 PE20090704A1 PE2008001616A PE2008001616A PE20090704A1 PE 20090704 A1 PE20090704 A1 PE 20090704A1 PE 2008001616 A PE2008001616 A PE 2008001616A PE 2008001616 A PE2008001616 A PE 2008001616A PE 20090704 A1 PE20090704 A1 PE 20090704A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- tricycle
- hexahydroisocromene
- pirrol
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE HETEROCICLICOS TRICICLICOS DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C6), ALQUENILO(C2-C6), ALQUINILO(C2-C6), ENTRE OTROS; R2 ES H, CICLOALQUILO(C3-C7), ALQUILO C1.C6, CICLOALQUILO(C3-C7)-ALQUILO(C1-C2), ENTRE OTROS; R3 ES H, ALQUILO(C1-C6), ALCOXI(C1-C4)-ALQUILO(C1-C2),ENTE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS; X ES O, S, SO, SO2, ENTRE OTROS; Y1 ES N, CR6; Y2 ES N, CR7; Y3 ES N, CR8; Y4 ES N, CR9, DONDE NO MAS DE UNO DE Y1-Y4 PUEDE SER SIMULTANEAMENTE N; R6, R7 Y R8 SON CADA UNO H, ALQUENILO(C2-C6), ALQUILOXI(C1-C6), ENTRE OTROS; R9 ES H, HALO, CN, ALQUILOXI(C1-C6), ENTRE OTROS; m ES DE 1-2; n ES DE 0-1. SON COMPUESTOS PREFERIDOS: CIS-6-CLORO-1,2,3a,5,9b-HEXAHIDROISOCROMENO[3,4-c]PIRROL; CIS-6-(TRIFLUOROMETIL)-1,2,3,3a,5,9b-HEXAHIDROISOCROMENO[3,4-c]PIRROL; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS MODULADORES DEL RECEPTOR 5-HT2, UTILES EN EL TRATAMIENTO DE LA OBESIDAD, ESQUIZOFRENIA Y DISFUNCION COGNITIVA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07116561 | 2007-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090704A1 true PE20090704A1 (es) | 2009-06-20 |
Family
ID=39718515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001616A PE20090704A1 (es) | 2007-09-17 | 2008-09-16 | Derivados heterociclicos triciclicos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20100210680A1 (es) |
| EP (1) | EP2203454A1 (es) |
| JP (1) | JP5447380B2 (es) |
| KR (1) | KR20100072027A (es) |
| CN (1) | CN101801980B (es) |
| AR (1) | AR068521A1 (es) |
| AU (1) | AU2008300607B2 (es) |
| BR (1) | BRPI0816992A2 (es) |
| CA (1) | CA2698436A1 (es) |
| CL (1) | CL2008002767A1 (es) |
| CO (1) | CO6260138A2 (es) |
| MX (1) | MX2010002900A (es) |
| NZ (1) | NZ583627A (es) |
| PE (1) | PE20090704A1 (es) |
| RU (1) | RU2010115337A (es) |
| TW (1) | TW200924752A (es) |
| WO (1) | WO2009037220A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8518933B2 (en) * | 2009-04-23 | 2013-08-27 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
| US8546377B2 (en) * | 2009-04-23 | 2013-10-01 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
| SG10201706590VA (en) * | 2009-05-22 | 2017-09-28 | Abbvie Inc | Modulators of 5-ht receptors and methods of use thereof |
| KR101770979B1 (ko) * | 2010-05-21 | 2017-08-24 | 애브비 인코포레이티드 | 5ｈｔ 수용체의 조절제 및 이의 사용방법 |
| WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| US20120309796A1 (en) | 2011-06-06 | 2012-12-06 | Fariborz Firooznia | Benzocycloheptene acetic acids |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| US20210017174A1 (en) | 2018-03-07 | 2021-01-21 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitor |
| WO2024091983A1 (en) * | 2022-10-25 | 2024-05-02 | Artus Therapeutics, Inc. | Therapeutic agents for enhancing epithelial and/or endothelial barrier function |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132710A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| US4132709A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna & Harrison, Ltd. | [2]Benzopyrano[4,3-c]pyridine derivatives and process therefor |
| NL8005754A (nl) | 1980-10-18 | 1982-05-17 | Akzo Nv | Benzo 4,5 pyrano 2,3-c pyrrool derivaten. |
| US4666916A (en) * | 1985-11-08 | 1987-05-19 | Ciba-Geigy Corporation | Hexahydro-(1)-benzo-(pyrano and thiopyrano) (4,3-C)pyridines, useful as serotin-2 blocking agents |
| ES2090119T3 (es) * | 1988-12-15 | 1996-10-16 | Abbott Lab | Agentes selectivos de 5-ht. |
| US5049564A (en) * | 1989-11-17 | 1991-09-17 | Abbott Laboratories | 5-HT selective agents |
| GB8917333D0 (en) * | 1989-07-28 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| JPH07500333A (ja) * | 1991-10-24 | 1995-01-12 | ジ・アップジョン・カンパニー | ベンゾ−イソキノリン誘導体 |
| FR2722194B1 (fr) * | 1994-07-06 | 1996-08-23 | Adir | Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent |
-
2008
- 2008-09-10 TW TW097134706A patent/TW200924752A/zh unknown
- 2008-09-15 KR KR1020107008334A patent/KR20100072027A/ko not_active Application Discontinuation
- 2008-09-15 BR BRPI0816992 patent/BRPI0816992A2/pt not_active Application Discontinuation
- 2008-09-15 NZ NZ583627A patent/NZ583627A/en not_active IP Right Cessation
- 2008-09-15 RU RU2010115337/04A patent/RU2010115337A/ru unknown
- 2008-09-15 MX MX2010002900A patent/MX2010002900A/es not_active Application Discontinuation
- 2008-09-15 CA CA2698436A patent/CA2698436A1/en not_active Abandoned
- 2008-09-15 WO PCT/EP2008/062229 patent/WO2009037220A1/en active Application Filing
- 2008-09-15 EP EP08804190A patent/EP2203454A1/en not_active Withdrawn
- 2008-09-15 JP JP2010524519A patent/JP5447380B2/ja not_active Expired - Fee Related
- 2008-09-15 CN CN200880107460.7A patent/CN101801980B/zh not_active Expired - Fee Related
- 2008-09-15 AU AU2008300607A patent/AU2008300607B2/en not_active Ceased
- 2008-09-15 US US12/678,184 patent/US20100210680A1/en not_active Abandoned
- 2008-09-16 PE PE2008001616A patent/PE20090704A1/es not_active Application Discontinuation
- 2008-09-16 CL CL2008002767A patent/CL2008002767A1/es unknown
- 2008-09-16 AR ARP080104015A patent/AR068521A1/es unknown
-
2010
- 2010-03-17 CO CO10031803A patent/CO6260138A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5447380B2 (ja) | 2014-03-19 |
| RU2010115337A (ru) | 2011-10-27 |
| CA2698436A1 (en) | 2009-03-26 |
| JP2010539139A (ja) | 2010-12-16 |
| CN101801980A (zh) | 2010-08-11 |
| NZ583627A (en) | 2011-08-26 |
| WO2009037220A1 (en) | 2009-03-26 |
| TW200924752A (en) | 2009-06-16 |
| BRPI0816992A2 (pt) | 2015-03-24 |
| AU2008300607B2 (en) | 2013-08-22 |
| EP2203454A1 (en) | 2010-07-07 |
| CO6260138A2 (es) | 2011-03-22 |
| US20100210680A1 (en) | 2010-08-19 |
| AU2008300607A1 (en) | 2009-03-26 |
| CL2008002767A1 (es) | 2009-03-06 |
| AR068521A1 (es) | 2009-11-18 |
| KR20100072027A (ko) | 2010-06-29 |
| MX2010002900A (es) | 2010-03-31 |
| CN101801980B (zh) | 2014-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |