PE20090626A1 - Nuevos polimorfos del compuesto acido 2-{2-cloro-5-{[(2s)-3-(5-cloro-1'h,3h-espiro[1-benzofurano-2,4'-piperidin]-1'-il)-2-hidroxipropil]oxi}-4-[(metilamino)carbonil]fenoxi}-2-metilpropanoico, y sus sales clorhidrato e hidroxido de sodio, y del compue - Google Patents

Nuevos polimorfos del compuesto acido 2-{2-cloro-5-{[(2s)-3-(5-cloro-1'h,3h-espiro[1-benzofurano-2,4'-piperidin]-1'-il)-2-hidroxipropil]oxi}-4-[(metilamino)carbonil]fenoxi}-2-metilpropanoico, y sus sales clorhidrato e hidroxido de sodio, y del compue

Info

Publication number
PE20090626A1
PE20090626A1 PE2008001217A PE2008001217A PE20090626A1 PE 20090626 A1 PE20090626 A1 PE 20090626A1 PE 2008001217 A PE2008001217 A PE 2008001217A PE 2008001217 A PE2008001217 A PE 2008001217A PE 20090626 A1 PE20090626 A1 PE 20090626A1
Authority
PE
Peru
Prior art keywords
chloro
methylpropanoic
benzofuran
piperidin
methylamine
Prior art date
Application number
PE2008001217A
Other languages
English (en)
Inventor
Svetlana Ivanova
Martin Hemmerling
Hakan Schulz
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38957025&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090626(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090626A1 publication Critical patent/PE20090626A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C07D303/23—Oxiranylmethyl ethers of compounds having one hydroxy group bound to a six-membered aromatic ring, the oxiranylmethyl radical not being further substituted, i.e.
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE ACIDO 2-{2-CLORO-5-{[(2S)-3-(5-CLORO-1´H,3H-ESPIRO[1-BENZOFURANO-2,4´-PIPERIDIN]-1´IL-)-2-HIDROXIPROPIL]OXI}-4-[(METILAMINO)CARBONIL]FENOXI}-2-METILPROPANOICO Y ACIDO 2-{2-CLORO-5-{[(2R)-3-(5-CLORO-1´H,3H-ESPIRO[1-BENZOFURANO-2,4´-PIPERIDIN]-1´IL)-2-HIDROXIPROPIL]OXI}-4-[(METILAMINO)CARBONIL]FENOXI}-2-METILPROPANOICO CARACTERIZADO POR UN PICO DE DIFRACCION POR POLVO DE RAYOS X (EXPRESADOS EN GRADOS 2 TETA): 10,2; 15,4; 17,0; 21,2 Y 27,1. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS, INFLAMATORIAS, EPOC Y/O ASMA
PE2008001217A 2006-07-19 2008-07-17 Nuevos polimorfos del compuesto acido 2-{2-cloro-5-{[(2s)-3-(5-cloro-1'h,3h-espiro[1-benzofurano-2,4'-piperidin]-1'-il)-2-hidroxipropil]oxi}-4-[(metilamino)carbonil]fenoxi}-2-metilpropanoico, y sus sales clorhidrato e hidroxido de sodio, y del compue PE20090626A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83177606P 2006-07-19 2006-07-19
PCT/SE2007/000694 WO2008010765A1 (en) 2006-07-19 2007-07-17 Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity

Publications (1)

Publication Number Publication Date
PE20090626A1 true PE20090626A1 (es) 2009-06-20

Family

ID=38957025

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001217A PE20090626A1 (es) 2006-07-19 2008-07-17 Nuevos polimorfos del compuesto acido 2-{2-cloro-5-{[(2s)-3-(5-cloro-1'h,3h-espiro[1-benzofurano-2,4'-piperidin]-1'-il)-2-hidroxipropil]oxi}-4-[(metilamino)carbonil]fenoxi}-2-metilpropanoico, y sus sales clorhidrato e hidroxido de sodio, y del compue

Country Status (17)

Country Link
US (2) US20080167332A1 (es)
EP (1) EP2069355A4 (es)
JP (1) JP2009543860A (es)
KR (1) KR20090030347A (es)
CN (1) CN101553493B (es)
AR (2) AR061923A1 (es)
AU (1) AU2007275931B2 (es)
BR (1) BRPI0714463A2 (es)
CA (1) CA2657639A1 (es)
CL (2) CL2007002099A1 (es)
IL (1) IL196323A0 (es)
MX (1) MX2009000475A (es)
NO (1) NO20090760L (es)
PE (1) PE20090626A1 (es)
TW (2) TW200821316A (es)
UY (1) UY30493A1 (es)
WO (1) WO2008010765A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
EP2069355A4 (en) * 2006-07-19 2010-03-24 Astrazeneca Ab NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
GB0702456D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab New combination
WO2008103125A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2008103126A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2009082343A1 (en) 2007-12-20 2009-07-02 Astrazeneca Ab Dispenser and method for entraining powder in an airflow 537
GB0808709D0 (en) * 2008-05-13 2008-06-18 Astrazeneca Ab New combination 295
EP2300464A1 (en) 2008-05-13 2011-03-30 AstraZeneca AB Quinuclidine derivatives as muscarinic m3 receptor antagonists
GB0811099D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination 376
WO2010007408A2 (en) * 2008-07-14 2010-01-21 Astrazeneca Ab Intermediates 2-(2-chloro-5-hydroxy-4-methylcarbamoylphenoxy)-2-methylpropionic acid tert-butyl ester and glycidyl benzene sulfonates or salts thereof and the process for preparation of said intermediates
GB0814729D0 (en) * 2008-08-12 2008-09-17 Argenta Discovery Ltd New combination
CN102176940B (zh) 2008-10-08 2014-10-01 阿斯利康(瑞典)有限公司 具有与盖移动相关的索引的吸入器
WO2010042033A1 (en) 2008-10-08 2010-04-15 Astrazeneca Ab Inhalation device and method of dispensing medicament
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
RU2011153723A (ru) * 2009-06-10 2013-07-20 Суновион Фармасьютикалз Инк. Обратные агонисты и антагонисты н3 рецепторов гистамина и способы их применения
WO2011002406A1 (en) 2009-07-01 2011-01-06 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
US8410139B2 (en) * 2009-10-07 2013-04-02 Bristol-Myers Squibb Company Prodrugs of a piperidinyl derivative as modulators of chemokine receptor activity
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
AR078948A1 (es) * 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
WO2011073662A1 (en) 2009-12-17 2011-06-23 Astrazeneca Ab Combination of a benzoxazinone and a further agent for treating respiratory diseases
NZ601454A (en) 2010-02-10 2014-06-27 Astrazeneca Uk Ltd Process for providing a filled canister for an inhaler
IN2013MN00222A (es) 2010-07-21 2015-05-29 Astrazeneca Ab
MX2013000687A (es) 2010-07-21 2013-01-29 Astrazeneca Ab Inhalador.
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
WO2012163848A1 (en) 2011-05-27 2012-12-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of crohn's disease
GB201115874D0 (en) 2011-09-14 2011-10-26 Astrazeneca Ab Inhaler
GB201115870D0 (en) 2011-09-14 2011-10-26 Astrazeneca Ab Inhaler
EP3730590A1 (de) * 2014-03-10 2020-10-28 Merck Patent GmbH Flüssigkristalline medien mit homöotroper ausrichtung
NL2019273B1 (nl) 2017-07-19 2019-02-25 Synbra Tech B V houder voor vloeistoffen
CN111170753B (zh) * 2020-01-21 2022-05-17 烟台大学 一种具有耐高温性能的含电路屏陶瓷吸波材料及其制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010201A (en) * 1974-04-12 1977-03-01 The Upjohn Company Organic compounds
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
GB8334494D0 (en) 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
DE3822449A1 (de) * 1988-07-02 1990-01-04 Henkel Kgaa Oxidationshaarfaerbemittel mit neuen kupplern
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
US5962462A (en) * 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
GB0015876D0 (en) 2000-06-28 2000-08-23 Novartis Ag Organic compounds
DE10050995A1 (de) 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE60224172T2 (de) 2001-03-22 2008-12-04 Glaxo Group Ltd., Greenford Formanilid-derivative als beta2-adrenorezeptor-agonisten
US7291608B2 (en) 2001-04-30 2007-11-06 Glaxo Group Limited Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α
US20030229058A1 (en) 2001-11-13 2003-12-11 Moran Edmund J. Aryl aniline beta2 adrenergic receptor agonists
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
DE10216339A1 (de) 2002-04-13 2003-10-23 Boehringer Ingelheim Pharma Neue Ester hydroxy-substituierter Stickstoffheterocyclen, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
SE0202133D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
CA2499314C (en) 2002-10-11 2010-08-24 Pfizer Inc. Indole derivatives as beta-2 agonists
US20040092529A1 (en) * 2002-10-30 2004-05-13 Pfizer Inc Methods of using piperazine derivatives
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
ATE555087T1 (de) * 2002-11-27 2012-05-15 Incyte Corp 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren
US20070021498A1 (en) * 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
SE0302811D0 (sv) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
CN100450488C (zh) 2003-11-03 2009-01-14 诺顿·希尔思凯尔有限公司 用于干粉吸入剂的软类固醇组合物
SE0303090D0 (sv) * 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303280D0 (sv) * 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
ES2257152B1 (es) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
CA2584413A1 (en) 2004-10-29 2006-05-04 Astrazeneca Ab Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases
US20060167044A1 (en) * 2004-12-20 2006-07-27 Arnaiz Damian O Piperidine derivatives and their use as anti-inflammatory agents
EP2069355A4 (en) * 2006-07-19 2010-03-24 Astrazeneca Ab NOVEL TRICYCLIC SPIROPIPERIDINE COMPOUNDS, THEIR SYNTHESIS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
WO2008103125A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
WO2008103126A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma

Also Published As

Publication number Publication date
KR20090030347A (ko) 2009-03-24
NO20090760L (no) 2009-04-14
CN101553493B (zh) 2012-07-04
CL2007002099A1 (es) 2008-02-22
AU2007275931A1 (en) 2008-01-24
IL196323A0 (en) 2009-09-22
UY30493A1 (es) 2008-02-29
TW200909433A (en) 2009-03-01
EP2069355A1 (en) 2009-06-17
US20090176815A1 (en) 2009-07-09
AR068323A1 (es) 2009-11-11
TW200821316A (en) 2008-05-16
AR061923A1 (es) 2008-10-01
US20080167332A1 (en) 2008-07-10
CN101553493A (zh) 2009-10-07
BRPI0714463A2 (pt) 2013-04-02
EP2069355A4 (en) 2010-03-24
AU2007275931B2 (en) 2011-06-16
CA2657639A1 (en) 2008-01-24
MX2009000475A (es) 2009-07-10
JP2009543860A (ja) 2009-12-10
CL2008002107A1 (es) 2009-07-17
WO2008010765A1 (en) 2008-01-24

Similar Documents

Publication Publication Date Title
PE20090626A1 (es) Nuevos polimorfos del compuesto acido 2-{2-cloro-5-{[(2s)-3-(5-cloro-1'h,3h-espiro[1-benzofurano-2,4'-piperidin]-1'-il)-2-hidroxipropil]oxi}-4-[(metilamino)carbonil]fenoxi}-2-metilpropanoico, y sus sales clorhidrato e hidroxido de sodio, y del compue
TW200736221A (en) Novel pharmaceutical salts and polymorphs of a Factor Xa inhibitor
CY1111867T1 (el) Ενωση ενεργοποιησης ppar και φαρμακευτικη συνθεση που περιεχει αυτη
SE0200979D0 (sv) New compounds
BRPI0621386B8 (pt) composição farmacêutica para o uso externo
ZA200702700B (en) Diagnostic compounds
NZ599979A (en) Flexible forehead support
NZ607794A (en) N-acylsulfonamide apoptosis promoters
TW200833682A (en) Pharmaceutical compounds
EA200970296A1 (ru) Содержащие диариловый эфир соединения мочевины
SG148177A1 (en) Novel cis-imidazolines
SI1694318T1 (sl) (S)-2-N-propilamino-5-hidroksitetralin kot terapevtsko sredstvo z agonističnim učinkom na D3
IL190551A0 (en) Novel process for the preparation of acid chlorides
MX2010003603A (es) Metodo para el tratamiento de enfermedades de riñon poliquisticas con derivados de ceramida.
PA8638201A1 (es) Forma cristalina alfa del ranelato de estroncio procedimiento para su preparacion y composiciones farmaceuticas que la contienen
IT1399590B1 (it) Apparato e kit per incapsulare almeno un composto ad uso terapeutico e/o diagnostico all'interno di eritrociti
RS53521B1 (en) PREPARATION AND THERAPY APPLICATIONS (2S, 3R) -N-2 - ((3-pyridinyl) methyl) -1-AZABICYCLO [2.2.2] OCT-3-IL) -3,5-DIFLUOROBENZAMIDE
TW200800984A (en) New compounds
EA200800324A1 (ru) Новый способ получения солей тиотропия
MXPA05013751A (es) Procedimiento e intermediarios para la preparacion de 3-(amino)-3-ciclobutilmetil-2-hidroxi-propionamida o sus sales.
MY163501A (en) Anti-biofilm carbonate compouns for use in oral care compositions
JO2781B1 (en) A new process for the synthesis of ivabradine and its addition salts with pharmaceutically acceptable acid.
MX2011012068A (es) Nucleosidos 2'-fluoro arabino y su utilizaicon.
ITMI20022394A1 (it) Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche.
SG165254A1 (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Legal Events

Date Code Title Description
FC Refusal