PE20071323A1 - {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-((R)-1-FENIL-ETIL)-AMINA EN EL TRATAMIENTO DE CANCER - Google Patents

{6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-((R)-1-FENIL-ETIL)-AMINA EN EL TRATAMIENTO DE CANCER

Info

Publication number
PE20071323A1
PE20071323A1 PE2007000072A PE2007000072A PE20071323A1 PE 20071323 A1 PE20071323 A1 PE 20071323A1 PE 2007000072 A PE2007000072 A PE 2007000072A PE 2007000072 A PE2007000072 A PE 2007000072A PE 20071323 A1 PE20071323 A1 PE 20071323A1
Authority
PE
Peru
Prior art keywords
phenyl
ethyl
ilmrtil
piperazin
amine
Prior art date
Application number
PE2007000072A
Other languages
English (en)
Inventor
Michael Mutz
Reto Fisher
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37946476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071323(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20071323A1 publication Critical patent/PE20071323A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UNA FORMA CRISTALINA DE {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDN-4-IL}-((R)-1-FENIL-ETIL)-AMINA, CARACTERIZADA POR UN PATRON DE DIFRACCION DE RAYOS X, EXPRESADO EN TERMINOS DE 2 THETA ANGULOS, QUE INCLUYE 5 O MAS PICOS SELECCIONADOS DE 4.4; 8.8; 9.1; 13.2; 14.2; 17.2; 18.2; 19.4+-0.2. Y UN ESPECTRO DE ABSORCION INFRARROJA CON BANDAS DE ABSORCION A APROXIMADAMENTE 695, 802, 836, 923, 1013, 1095, 1146, 1165, 1207, 1229, 1292, 1300, 1310, 1348, 1358, 1507, 1546, 1595, Y 3269 +-2 cm-1. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHO COMPUESTO INHIBE A EFG Y VEGF UTILES EN EL CANCER DE MAMA, CANCER DE COLON, OVARIO, ENTRE OTROS
PE2007000072A 2006-01-23 2007-01-23 {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-((R)-1-FENIL-ETIL)-AMINA EN EL TRATAMIENTO DE CANCER PE20071323A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76122406P 2006-01-23 2006-01-23

Publications (1)

Publication Number Publication Date
PE20071323A1 true PE20071323A1 (es) 2008-02-15

Family

ID=37946476

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000072A PE20071323A1 (es) 2006-01-23 2007-01-23 {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-((R)-1-FENIL-ETIL)-AMINA EN EL TRATAMIENTO DE CANCER

Country Status (13)

Country Link
EP (1) EP1979357A1 (es)
JP (1) JP2009523768A (es)
KR (1) KR20080095859A (es)
CN (1) CN101370814A (es)
AR (1) AR059090A1 (es)
AU (1) AU2007206925A1 (es)
BR (1) BRPI0706729A2 (es)
CA (1) CA2636954A1 (es)
PE (1) PE20071323A1 (es)
RU (1) RU2008134314A (es)
TN (1) TNSN08312A1 (es)
TW (1) TW200738719A (es)
WO (1) WO2007082946A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011349A1 (es) * 2000-06-16 2002-01-19 Upjohn Co 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
GB0119249D0 (en) * 2001-08-07 2001-10-03 Novartis Ag Organic compounds
EP1441736A2 (en) * 2001-10-29 2004-08-04 Novartis AG Use of 7h-pyrrolo[2,3-d]pyrimidine derivatives in the treatment of solid tumor diseases
US20080227980A1 (en) * 2005-08-05 2008-09-18 Novartis Ag Preparation of a 7H-Pyrrolo [2,3-D] Pyrimidine Derivative

Also Published As

Publication number Publication date
JP2009523768A (ja) 2009-06-25
BRPI0706729A2 (pt) 2011-04-05
TW200738719A (en) 2007-10-16
CN101370814A (zh) 2009-02-18
WO2007082946A1 (en) 2007-07-26
TNSN08312A1 (en) 2009-12-29
EP1979357A1 (en) 2008-10-15
KR20080095859A (ko) 2008-10-29
AR059090A1 (es) 2008-03-12
AU2007206925A1 (en) 2007-07-26
RU2008134314A (ru) 2010-02-27
CA2636954A1 (en) 2007-07-26

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