TNSN08312A1 - Solid forms of a pyrrolopyrimidine derivative and their use as anti-tumor agents - Google Patents

Solid forms of a pyrrolopyrimidine derivative and their use as anti-tumor agents

Info

Publication number
TNSN08312A1
TNSN08312A1 TNP2008000312A TNSN08312A TNSN08312A1 TN SN08312 A1 TNSN08312 A1 TN SN08312A1 TN P2008000312 A TNP2008000312 A TN P2008000312A TN SN08312 A TNSN08312 A TN SN08312A TN SN08312 A1 TNSN08312 A1 TN SN08312A1
Authority
TN
Tunisia
Prior art keywords
phenyl
ethyl
piperazin
pyrrolo
pyrimidin
Prior art date
Application number
TNP2008000312A
Inventor
Reto Fischer
Michael Mutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37946476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN08312(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TNSN08312A1 publication Critical patent/TNSN08312A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention relates to new crystalline forms of {6-[4-{4-ethyl-piperazin-1 - ylmethyl]- phenyl ] -7H-pyrrolo[2,3-d]pyrimidin-4-yl}-((R)-1-phenyl-ethyl)-amine, the process for the preparation of these crystalline forms of {6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H- pyrrolo[2,3-d]pyrimidin-4-yl}-((R)-1 -phenyl-ethyl)-amine, compositions containing these crystalline forms of {6-[4-(4-ethyl-piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d ]pyrimidin-4-yl}-((R)-1-phenyl-ethyl)-amine, and the use of these crystalline forms of {6-[4-(4-ethyl- piperazin-1-ylmethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-{(R)-1-phenyl-ethyl)-amine in diagnostic methods or therapeutic treatment of warm-blooded animals, especially humans.
TNP2008000312A 2006-01-23 2008-07-22 Solid forms of a pyrrolopyrimidine derivative and their use as anti-tumor agents TNSN08312A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76122406P 2006-01-23 2006-01-23
PCT/EP2007/050567 WO2007082946A1 (en) 2006-01-23 2007-01-19 Solid forms of a pyrrolopyrimidine derivative and their use as anti-tumor agents

Publications (1)

Publication Number Publication Date
TNSN08312A1 true TNSN08312A1 (en) 2009-12-29

Family

ID=37946476

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2008000312A TNSN08312A1 (en) 2006-01-23 2008-07-22 Solid forms of a pyrrolopyrimidine derivative and their use as anti-tumor agents

Country Status (13)

Country Link
EP (1) EP1979357A1 (en)
JP (1) JP2009523768A (en)
KR (1) KR20080095859A (en)
CN (1) CN101370814A (en)
AR (1) AR059090A1 (en)
AU (1) AU2007206925A1 (en)
BR (1) BRPI0706729A2 (en)
CA (1) CA2636954A1 (en)
PE (1) PE20071323A1 (en)
RU (1) RU2008134314A (en)
TN (1) TNSN08312A1 (en)
TW (1) TW200738719A (en)
WO (1) WO2007082946A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011349A1 (en) * 2000-06-16 2002-01-19 Upjohn Co 1-ARIL-4-OXO-1,4-DIHYDRO-3-QUINOLINE CARBOXAMIDES AS ANTIVIRAL AGENTS
GB0119249D0 (en) * 2001-08-07 2001-10-03 Novartis Ag Organic compounds
EP1441736A2 (en) * 2001-10-29 2004-08-04 Novartis AG Use of 7h-pyrrolo[2,3-d]pyrimidine derivatives in the treatment of solid tumor diseases
US20080227980A1 (en) * 2005-08-05 2008-09-18 Novartis Ag Preparation of a 7H-Pyrrolo [2,3-D] Pyrimidine Derivative

Also Published As

Publication number Publication date
EP1979357A1 (en) 2008-10-15
TW200738719A (en) 2007-10-16
CN101370814A (en) 2009-02-18
AU2007206925A1 (en) 2007-07-26
PE20071323A1 (en) 2008-02-15
BRPI0706729A2 (en) 2011-04-05
JP2009523768A (en) 2009-06-25
RU2008134314A (en) 2010-02-27
CA2636954A1 (en) 2007-07-26
WO2007082946A1 (en) 2007-07-26
KR20080095859A (en) 2008-10-29
AR059090A1 (en) 2008-03-12

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