PE20071323A1 - {6- [4- (4-ETHYL-PIPERAZIN-1-ILMRTIL) -PHENYL] -7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL} - ((R) -1-PHENYL-ETHYL) - AMINE IN THE TREATMENT OF CANCER - Google Patents

{6- [4- (4-ETHYL-PIPERAZIN-1-ILMRTIL) -PHENYL] -7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL} - ((R) -1-PHENYL-ETHYL) - AMINE IN THE TREATMENT OF CANCER

Info

Publication number
PE20071323A1
PE20071323A1 PE2007000072A PE2007000072A PE20071323A1 PE 20071323 A1 PE20071323 A1 PE 20071323A1 PE 2007000072 A PE2007000072 A PE 2007000072A PE 2007000072 A PE2007000072 A PE 2007000072A PE 20071323 A1 PE20071323 A1 PE 20071323A1
Authority
PE
Peru
Prior art keywords
phenyl
ethyl
ilmrtil
piperazin
amine
Prior art date
Application number
PE2007000072A
Other languages
Spanish (es)
Inventor
Michael Mutz
Reto Fisher
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37946476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071323(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20071323A1 publication Critical patent/PE20071323A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

SE REFIERE A UNA FORMA CRISTALINA DE {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDN-4-IL}-((R)-1-FENIL-ETIL)-AMINA, CARACTERIZADA POR UN PATRON DE DIFRACCION DE RAYOS X, EXPRESADO EN TERMINOS DE 2 THETA ANGULOS, QUE INCLUYE 5 O MAS PICOS SELECCIONADOS DE 4.4; 8.8; 9.1; 13.2; 14.2; 17.2; 18.2; 19.4+-0.2. Y UN ESPECTRO DE ABSORCION INFRARROJA CON BANDAS DE ABSORCION A APROXIMADAMENTE 695, 802, 836, 923, 1013, 1095, 1146, 1165, 1207, 1229, 1292, 1300, 1310, 1348, 1358, 1507, 1546, 1595, Y 3269 +-2 cm-1. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHO COMPUESTO INHIBE A EFG Y VEGF UTILES EN EL CANCER DE MAMA, CANCER DE COLON, OVARIO, ENTRE OTROSREFERS TO A CRYSTALLINE FORM OF {6- [4- (4-ETHYL-PIPERAZIN-1-ILMRTIL) -PHENYL] -7H-PIRROLO [2,3-d] PYRIMIDN-4-IL} - ((R) - 1-PHENYL-ETHYL) -AMINE, CHARACTERIZED BY AN X-RAY DIFFRACTION PATTERN, EXPRESSED IN TERMS OF 2 THETA ANGLE, INCLUDING 5 OR MORE SELECTED PEAKS OF 4.4; 8.8; 9.1; 13.2; 14.2; 17.2; 18.2; 19.4 + -0.2. AND AN INFRARED ABSORPTION SPECTRUM WITH ABSORPTION BANDS AT APPROXIMATELY 695, 802, 836, 923, 1013, 1095, 1146, 1165, 1207, 1229, 1292, 1300, 1310, 1348, 1358, 1507, 1546, 1595, AND 3269 + -2 cm-1. ALSO REFERRED TO A PREPARATION PROCEDURE. SAID COMPOUND INHIBITS USEFUL EFG AND VEGF IN BREAST CANCER, COLON CANCER, OVARY, AMONG OTHERS

PE2007000072A 2006-01-23 2007-01-23 {6- [4- (4-ETHYL-PIPERAZIN-1-ILMRTIL) -PHENYL] -7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL} - ((R) -1-PHENYL-ETHYL) - AMINE IN THE TREATMENT OF CANCER PE20071323A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76122406P 2006-01-23 2006-01-23

Publications (1)

Publication Number Publication Date
PE20071323A1 true PE20071323A1 (en) 2008-02-15

Family

ID=37946476

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000072A PE20071323A1 (en) 2006-01-23 2007-01-23 {6- [4- (4-ETHYL-PIPERAZIN-1-ILMRTIL) -PHENYL] -7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL} - ((R) -1-PHENYL-ETHYL) - AMINE IN THE TREATMENT OF CANCER

Country Status (13)

Country Link
EP (1) EP1979357A1 (en)
JP (1) JP2009523768A (en)
KR (1) KR20080095859A (en)
CN (1) CN101370814A (en)
AR (1) AR059090A1 (en)
AU (1) AU2007206925A1 (en)
BR (1) BRPI0706729A2 (en)
CA (1) CA2636954A1 (en)
PE (1) PE20071323A1 (en)
RU (1) RU2008134314A (en)
TN (1) TNSN08312A1 (en)
TW (1) TW200738719A (en)
WO (1) WO2007082946A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011349A1 (en) * 2000-06-16 2002-01-19 Upjohn Co 1-ARIL-4-OXO-1,4-DIHYDRO-3-QUINOLINE CARBOXAMIDES AS ANTIVIRAL AGENTS
GB0119249D0 (en) * 2001-08-07 2001-10-03 Novartis Ag Organic compounds
EP1441736A2 (en) * 2001-10-29 2004-08-04 Novartis AG Use of 7h-pyrrolo[2,3-d]pyrimidine derivatives in the treatment of solid tumor diseases
US20080227980A1 (en) * 2005-08-05 2008-09-18 Novartis Ag Preparation of a 7H-Pyrrolo [2,3-D] Pyrimidine Derivative

Also Published As

Publication number Publication date
EP1979357A1 (en) 2008-10-15
TNSN08312A1 (en) 2009-12-29
TW200738719A (en) 2007-10-16
CN101370814A (en) 2009-02-18
AU2007206925A1 (en) 2007-07-26
BRPI0706729A2 (en) 2011-04-05
JP2009523768A (en) 2009-06-25
RU2008134314A (en) 2010-02-27
CA2636954A1 (en) 2007-07-26
WO2007082946A1 (en) 2007-07-26
KR20080095859A (en) 2008-10-29
AR059090A1 (en) 2008-03-12

Similar Documents

Publication Publication Date Title
AR063347A1 (en) DOCETAXEL CRYSTAL FORMS AND PROCESS FOR PREPARATION
LTC2100614I2 (en) Antibody against PDGFR-alpha for use in the treatment of tumors
PE20080974A1 (en) NEW PYROZOLOPYRIMIDINES AS CYCLINE-DEPENDENT KINASE INHIBITORS
WO2007120654A3 (en) Process for making contained layers and devices made with same
HK1129948A1 (en) Organic double-heterostructure photovoltaic cells having reciprocal-carrier exciton blocking layer
EP1857520A4 (en) Composition for heat-storage object formation, heat-storage object, and process for producing heat-storage object
EP2040099A4 (en) Photochromic film, photochromic lens having the same, and process for producing photochromic lens
IL185049A0 (en) Organic silver complexes, their preparation methods and their methods for forming thin layers
EP1917220A4 (en) Synthesized hybrid rock composition, method, and article formed by the method
EP2216312A4 (en) Process for producing organic compound and organic compound obtained by the same
DE502008000766D1 (en) Blowing machine with garniture holder, as well as garniture holder
NL1031626A1 (en) Compounds useful in therapy.
ZA200709177B (en) Combined multi-layered water soluble film and process for producing the same
EP1743915A4 (en) Oriented film, process for producing the same and laminate thereof
JP2012036197A5 (en)
EP1967518A4 (en) Process for producing propylene oxide
EP1951222A4 (en) Method of treating breast cancer using 17-aag or 17-ag or a prodrug of either in combination with a her2 inhibitor
EP2075091A4 (en) Laminate, abrasive and grinding materials made by using the same, and process for formation of the laminate
EP2048141A4 (en) Optical pure dihydropyrimidine compounds, their uses in the manufacture of a medicamnent for the treatment or the prevention of virosis diseases
DE502006009099D1 (en) CONSTRUCTION MACHINE, AS WELL AS SWIVELING DEVICE
EP1846422A4 (en) Organic silver complexes, their preparation methods and their methods for forming thin layers
EP1952811A4 (en) The use of eriocalyxin b in the manufacture of medicaments for treating leukemia
PE20071323A1 (en) {6- [4- (4-ETHYL-PIPERAZIN-1-ILMRTIL) -PHENYL] -7H-PYRROLO [2,3-d] PYRIMIDIN-4-IL} - ((R) -1-PHENYL-ETHYL) - AMINE IN THE TREATMENT OF CANCER
GB0803521D0 (en) A pharmaceutcal composition useful for the treatment of prostate cancer
EP1911812A4 (en) Process for producing melanin, melanin produced by the process, functional film containing the melanin, and process for producing the same

Legal Events

Date Code Title Description
FC Refusal