PE20070954A1 - Compuestos de benzoimidazolona-carboxamida como agonistas del receptor 5-ht4 - Google Patents

Compuestos de benzoimidazolona-carboxamida como agonistas del receptor 5-ht4

Info

Publication number
PE20070954A1
PE20070954A1 PE2006001486A PE2006001486A PE20070954A1 PE 20070954 A1 PE20070954 A1 PE 20070954A1 PE 2006001486 A PE2006001486 A PE 2006001486A PE 2006001486 A PE2006001486 A PE 2006001486A PE 20070954 A1 PE20070954 A1 PE 20070954A1
Authority
PE
Peru
Prior art keywords
alkyl
piperazine
oxo
carbonyl
oct
Prior art date
Application number
PE2006001486A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Long
Seok-Ki Choi
Paul R Fatheree
Adam Goldblum
Daniel Marquess
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of PE20070954A1 publication Critical patent/PE20070954A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PE2006001486A 2005-11-22 2006-11-21 Compuestos de benzoimidazolona-carboxamida como agonistas del receptor 5-ht4 PE20070954A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73870205P 2005-11-22 2005-11-22

Publications (1)

Publication Number Publication Date
PE20070954A1 true PE20070954A1 (es) 2007-09-10

Family

ID=38067868

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001486A PE20070954A1 (es) 2005-11-22 2006-11-21 Compuestos de benzoimidazolona-carboxamida como agonistas del receptor 5-ht4

Country Status (20)

Country Link
US (2) US7329752B2 (https=)
EP (1) EP1960396B1 (https=)
JP (1) JP2009516745A (https=)
KR (1) KR20080072727A (https=)
CN (1) CN101312967B (https=)
AR (1) AR057627A1 (https=)
AT (1) ATE448224T1 (https=)
AU (1) AU2006318507A1 (https=)
BR (1) BRPI0618835A2 (https=)
CA (1) CA2630222A1 (https=)
DE (1) DE602006010432D1 (https=)
EA (1) EA014819B1 (https=)
ES (1) ES2336952T3 (https=)
MY (1) MY143574A (https=)
NO (1) NO20082597L (https=)
NZ (1) NZ567653A (https=)
PE (1) PE20070954A1 (https=)
TW (1) TW200804366A (https=)
WO (1) WO2007062058A2 (https=)
ZA (1) ZA200804010B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
CN101384588B (zh) * 2006-02-16 2011-08-31 施万制药 制备5-ht4受体激动剂化合物的中间体的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223511A (en) 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
IT1231413B (it) 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
JP3829879B2 (ja) 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
IT1275903B1 (it) 1995-03-14 1997-10-24 Boehringer Ingelheim Italia Esteri e ammidi della 1,4-piperidina disostituita
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
IT1298271B1 (it) 1998-02-18 1999-12-20 Boehringer Ingelheim Italia Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico
EP1173168A2 (en) 1999-04-28 2002-01-23 Respiratorius AB Compound for use as a medicament for treatment of disorders involving bronchocontraction
IT1313625B1 (it) 1999-09-22 2002-09-09 Boehringer Ingelheim Italia Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina.
JP4181847B2 (ja) * 2002-10-25 2008-11-19 エルピーダメモリ株式会社 タイミング調整回路、半導体装置及びタイミング調整方法
KR100738784B1 (ko) 2003-09-03 2007-07-12 화이자 인코포레이티드 5-ｈｔ4 수용체 효능 활성을 갖는 벤즈이미다졸론
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
WO2006052889A2 (en) * 2004-11-05 2006-05-18 Theravance, Inc. Quinolinone-carboxamide compounds
US7399862B2 (en) 2004-11-05 2008-07-15 Theravance, Inc. 5-HT4 receptor agonist compounds
CA2588037A1 (en) 2004-12-22 2006-06-29 Theravance, Inc. Indazole-carboxamide compounds
CN101163701A (zh) * 2005-03-02 2008-04-16 施万制药 作为5-ht4受体激动剂的喹啉酮化合物
US7351304B2 (en) * 2005-05-24 2008-04-01 General Electric Company Method and apparatus for reducing surface defects
EP1902053B1 (en) 2005-06-07 2011-01-12 Theravance, Inc. Benzoimidazolone-carboxamide compounds as 5-ht4 receptor agonists

Also Published As

Publication number Publication date
CA2630222A1 (en) 2007-05-31
US7851467B2 (en) 2010-12-14
EP1960396B1 (en) 2009-11-11
US20080090811A1 (en) 2008-04-17
ZA200804010B (en) 2009-02-25
EA014819B1 (ru) 2011-02-28
EA200801402A1 (ru) 2008-10-30
NZ567653A (en) 2011-06-30
CN101312967A (zh) 2008-11-26
MY143574A (en) 2011-05-31
DE602006010432D1 (de) 2009-12-24
WO2007062058A3 (en) 2007-09-07
AU2006318507A1 (en) 2007-05-31
US20070117796A1 (en) 2007-05-24
EP1960396A2 (en) 2008-08-27
ATE448224T1 (de) 2009-11-15
NO20082597L (no) 2008-06-10
ES2336952T3 (es) 2010-04-19
JP2009516745A (ja) 2009-04-23
AR057627A1 (es) 2007-12-05
US7329752B2 (en) 2008-02-12
CN101312967B (zh) 2011-08-24
BRPI0618835A2 (pt) 2011-09-13
WO2007062058A2 (en) 2007-05-31
TW200804366A (en) 2008-01-16
KR20080072727A (ko) 2008-08-06

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