AR057627A1 - Compuestos de carbamato como agonistas del receptor 5-ht4 - Google Patents
Compuestos de carbamato como agonistas del receptor 5-ht4Info
- Publication number
- AR057627A1 AR057627A1 ARP060105125A ARP060105125A AR057627A1 AR 057627 A1 AR057627 A1 AR 057627A1 AR P060105125 A ARP060105125 A AR P060105125A AR P060105125 A ARP060105125 A AR P060105125A AR 057627 A1 AR057627 A1 AR 057627A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- nrarb
- compounds
- formula
- 3alkyl
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 10
- 229910003827 NRaRb Inorganic materials 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 108091005482 5-HT4 receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73870205P | 2005-11-22 | 2005-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057627A1 true AR057627A1 (es) | 2007-12-05 |
Family
ID=38067868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060105125A AR057627A1 (es) | 2005-11-22 | 2006-11-22 | Compuestos de carbamato como agonistas del receptor 5-ht4 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7329752B2 (https=) |
| EP (1) | EP1960396B1 (https=) |
| JP (1) | JP2009516745A (https=) |
| KR (1) | KR20080072727A (https=) |
| CN (1) | CN101312967B (https=) |
| AR (1) | AR057627A1 (https=) |
| AT (1) | ATE448224T1 (https=) |
| AU (1) | AU2006318507A1 (https=) |
| BR (1) | BRPI0618835A2 (https=) |
| CA (1) | CA2630222A1 (https=) |
| DE (1) | DE602006010432D1 (https=) |
| EA (1) | EA014819B1 (https=) |
| ES (1) | ES2336952T3 (https=) |
| MY (1) | MY143574A (https=) |
| NO (1) | NO20082597L (https=) |
| NZ (1) | NZ567653A (https=) |
| PE (1) | PE20070954A1 (https=) |
| TW (1) | TW200804366A (https=) |
| WO (1) | WO2007062058A2 (https=) |
| ZA (1) | ZA200804010B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ560828A (en) * | 2005-03-02 | 2011-01-28 | Theravance Inc | Quinolinone compounds as 5-HT4 receptor agonists |
| CA2637214C (en) * | 2006-02-16 | 2014-04-22 | Theravance, Inc. | Process for preparing 8-azabicylo[3.2.1]octan-3-one intermediates to 5-ht4 receptor agonist compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1231413B (it) | 1987-09-23 | 1991-12-04 | Angeli Inst Spa | Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht |
| US5223511A (en) | 1987-09-23 | 1993-06-29 | Boehringer Ingelheim Italia S.P.A. | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists |
| JP3829879B2 (ja) * | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
| IT1275903B1 (it) | 1995-03-14 | 1997-10-24 | Boehringer Ingelheim Italia | Esteri e ammidi della 1,4-piperidina disostituita |
| US6069152A (en) | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| IT1298271B1 (it) | 1998-02-18 | 1999-12-20 | Boehringer Ingelheim Italia | Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico |
| WO2000064441A2 (en) | 1999-04-28 | 2000-11-02 | Respiratorius Ab | Compound for use as a medicament for treatment of disorders involving bronchocontraction |
| IT1313625B1 (it) | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
| JP4181847B2 (ja) * | 2002-10-25 | 2008-11-19 | エルピーダメモリ株式会社 | タイミング調整回路、半導体装置及びタイミング調整方法 |
| UA86204C2 (uk) | 2003-09-03 | 2009-04-10 | Пфайзер Инк. | Сполуки бензімідазолону, які мають 5-нт4 рецепторну агоністичну активність |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| EP1807423B1 (en) | 2004-11-05 | 2009-05-20 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| ATE441646T1 (de) | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
| ATE469897T1 (de) | 2004-12-22 | 2010-06-15 | Theravance Inc | Indazolcarbonsäureamidverbindungen |
| NZ560828A (en) * | 2005-03-02 | 2011-01-28 | Theravance Inc | Quinolinone compounds as 5-HT4 receptor agonists |
| US7351304B2 (en) * | 2005-05-24 | 2008-04-01 | General Electric Company | Method and apparatus for reducing surface defects |
| US7317022B2 (en) | 2005-06-07 | 2008-01-08 | Theravance, Inc. | Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists |
-
2006
- 2006-11-09 MY MYPI20064472A patent/MY143574A/en unknown
- 2006-11-15 TW TW095142293A patent/TW200804366A/zh unknown
- 2006-11-21 US US11/602,888 patent/US7329752B2/en active Active
- 2006-11-21 CN CN2006800433139A patent/CN101312967B/zh not_active Expired - Fee Related
- 2006-11-21 ES ES06838207T patent/ES2336952T3/es active Active
- 2006-11-21 WO PCT/US2006/045099 patent/WO2007062058A2/en not_active Ceased
- 2006-11-21 JP JP2008542415A patent/JP2009516745A/ja active Pending
- 2006-11-21 CA CA002630222A patent/CA2630222A1/en not_active Abandoned
- 2006-11-21 AT AT06838207T patent/ATE448224T1/de not_active IP Right Cessation
- 2006-11-21 EP EP06838207A patent/EP1960396B1/en active Active
- 2006-11-21 KR KR1020087014898A patent/KR20080072727A/ko not_active Ceased
- 2006-11-21 EA EA200801402A patent/EA014819B1/ru not_active IP Right Cessation
- 2006-11-21 DE DE602006010432T patent/DE602006010432D1/de active Active
- 2006-11-21 BR BRPI0618835-4A patent/BRPI0618835A2/pt not_active IP Right Cessation
- 2006-11-21 PE PE2006001486A patent/PE20070954A1/es not_active Application Discontinuation
- 2006-11-21 AU AU2006318507A patent/AU2006318507A1/en not_active Abandoned
- 2006-11-21 NZ NZ567653A patent/NZ567653A/en unknown
- 2006-11-22 AR ARP060105125A patent/AR057627A1/es not_active Application Discontinuation
-
2007
- 2007-12-06 US US11/999,609 patent/US7851467B2/en not_active Expired - Fee Related
-
2008
- 2008-05-09 ZA ZA200804010A patent/ZA200804010B/xx unknown
- 2008-06-10 NO NO20082597A patent/NO20082597L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009516745A (ja) | 2009-04-23 |
| WO2007062058A2 (en) | 2007-05-31 |
| EA200801402A1 (ru) | 2008-10-30 |
| ES2336952T3 (es) | 2010-04-19 |
| EP1960396B1 (en) | 2009-11-11 |
| CN101312967A (zh) | 2008-11-26 |
| US7851467B2 (en) | 2010-12-14 |
| CA2630222A1 (en) | 2007-05-31 |
| US20080090811A1 (en) | 2008-04-17 |
| PE20070954A1 (es) | 2007-09-10 |
| WO2007062058A3 (en) | 2007-09-07 |
| BRPI0618835A2 (pt) | 2011-09-13 |
| NZ567653A (en) | 2011-06-30 |
| ZA200804010B (en) | 2009-02-25 |
| MY143574A (en) | 2011-05-31 |
| KR20080072727A (ko) | 2008-08-06 |
| ATE448224T1 (de) | 2009-11-15 |
| US20070117796A1 (en) | 2007-05-24 |
| NO20082597L (no) | 2008-06-10 |
| US7329752B2 (en) | 2008-02-12 |
| CN101312967B (zh) | 2011-08-24 |
| EP1960396A2 (en) | 2008-08-27 |
| TW200804366A (en) | 2008-01-16 |
| DE602006010432D1 (de) | 2009-12-24 |
| EA014819B1 (ru) | 2011-02-28 |
| AU2006318507A1 (en) | 2007-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR047098A1 (es) | Derivados de arilanilina como agonistas del receptor adrenergico beta2 | |
| AR072952A1 (es) | Compuestos de 2-imino-3-metilpirrolopirimidinona fenilo-sustituida como inhibidores de bace-1, composiciones y su uso | |
| PE20230249A1 (es) | Compuestos de heteroarilo biciclicos y usos de estos | |
| PE20040164A1 (es) | Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas | |
| AR050407A1 (es) | Compuestos quinolinon-carboxamida como agonistas del receptor 5-ht4. procesos de obtencion y composiciones farmaceuticas | |
| EA200501504A1 (ru) | Лиганды каннабиноидных рецепторов и их применение | |
| AR045595A1 (es) | Composiciones utiles como inhibidores de proteinas quinasas | |
| AR063022A1 (es) | Derivados de indol antagonistas del receptor de glucagon, composiciones farmaceuticas que los contienen y usos para tratar diabetes mellitus tipo 2 y estados patologicos relacionados. | |
| PL2428519T3 (pl) | Kompozycja do wytwarzania 17-winylo-trifluorometanosulfonianów jako związków pośrednich | |
| AR046085A1 (es) | Agonistas etilamino amino sustituidos del receptor beta 2 adrenergico | |
| AR078408A1 (es) | Derivados de indol como moduladores de los crac | |
| AR049446A1 (es) | Preparacion de pregabalina ((s)-(+)-aminometil-5-metilhexanoico) y compuestos relacionados | |
| AR070828A1 (es) | Derivados de azetidina y ciclobutano como inhibidores de jak | |
| MX2015015893A (es) | 2-fenilimidazo[1,2-a]pirimidinas como agentes formadores de imagen. | |
| EA200701745A1 (ru) | Циклопропанкарбоксамидные производные | |
| AR116474A1 (es) | DERIVADOS DEL ÁCIDO 6,7-DIHIDRO-2H-BENZOFURO[2,3-a]QUINOLIZIN-3-CARBOXÍLICO COMO AGENTES ANTIVIRALES PARA EL TRATAMIENTO O PREVENCIÓN DE UNA INFECCIÓN POR HBV | |
| MA28422B1 (fr) | Derives de n- (1,5-diphenyl-1h-pyrazol-3-yl) sulfonamide avec une affinite pour les recepteurs cb1 | |
| ATE431345T1 (de) | Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate | |
| EA201000881A1 (ru) | Пиридилметил-сульфонамидные соединения | |
| AR065583A1 (es) | Compuestos macrociclicos y composicion farmaceutica | |
| AR076362A1 (es) | Arilsulfonamidas 2,5-disustituidas antagonistas de ccr3, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento y/o prevencion de patologias autoinmunes e inflamatorias, entre otras. | |
| AR052314A1 (es) | Compuestos de tienopiridinona como agonistas del receptor 5-ht4 | |
| EA200701035A1 (ru) | Замещенные n-сульфониламинобензил-2-феноксиацетамидные соединения | |
| AR078120A1 (es) | Antagonistas de ccr3 de arilsulfonamida 2,5-disustituida y composiciones farmaceuticas | |
| ECSP077394A (es) | Compuestos aromáticos de arilsulfonilmetil o arilsulfonamida sustituida apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |