PE20070125A1 - NON-STEROID PROGESTERONE RECEPTOR MODULATORS - Google Patents
NON-STEROID PROGESTERONE RECEPTOR MODULATORSInfo
- Publication number
- PE20070125A1 PE20070125A1 PE2006000733A PE2006000733A PE20070125A1 PE 20070125 A1 PE20070125 A1 PE 20070125A1 PE 2006000733 A PE2006000733 A PE 2006000733A PE 2006000733 A PE2006000733 A PE 2006000733A PE 20070125 A1 PE20070125 A1 PE 20070125A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- progesterone receptor
- receptor modulators
- benzoxazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H, ALQUILO C1-C5 LINEAL O NO LINEAL, RAMIFICADO O NO; R3 ES CC-Ra; Ra ES H, ALQUILO C1-C8, ALQUENILO C2-C8, CICLOALQUILO C3-C10, ENTRE OTROS; R4 ES H, METILO, ETILO, ALQUILO C1-C3 PARCIAL O TOTALMENTE FLUORADO; A ES ANILLO AROMATICO MONO O BICICLICO, CARBOCICLICO O HETEROCICLICO, OPCIONALMENTE MONO O POLI SUSTITUIDO CON ALQUILO C1-C8, ALQUENILO C2-C8, PERFLUOROALQUILO C1-C6, ENTRE OTROS; B ES CARBONILO, CH2. SON COMPUESTOS PREFERIDOS: (-)-6-{2-[2-(2,3-(METILENDIOXI)FENIL)-2-METILPROPIL]-2-HIDROXI-OCT-3-INAOIL}-4-METIL-2,3-BENZOXAZIN-1-ONA; 6-{2-[2-(2,3-DIHIDRO-7-BENZOFURANIL)-2-METILPROPIL]-2-HIDROXI-3-OCTINILAMINO}-4-METIL-2,3-BENZOXAZIN-1-ONA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES NO ESTEROIDES DE RECEPTOR DE PROGESTERONAIT REFERS TO A COMPOUND OF FORMULA I, WHERE R1 AND R2 ARE EACH H, C1-C5 ALKYL LINEAR OR NON-LINEAR, BRANCHED OR NOT; R3 IS CC-Ra; Ra IS H, C1-C8 ALKYL, C2-C8 ALKENYL, C3-C10 CYCLOALKYL, AMONG OTHERS; R4 IS H, METHYL, ETHYL, C1-C3 ALKYL PARTIALLY OR FULLY FLUORATED; A IS AROMATIC RING, MONO OR BICYCLIC, CARBOCYCLIC OR HETEROCICLIC, OPTIONALLY MONO OR POLY, SUBSTITUTED WITH C1-C8 ALKYL, C2-C8 ALKENYL, C1-C6 PERFLUOROALKYL, AMONG OTHERS; B IS CARBONYL, CH2. PREFERRED COMPOUNDS ARE: (-) - 6- {2- [2- (2,3- (METHYLEDIOXY) PHENYL) -2-METHYLPROPYL] -2-HYDROXY-OCT-3-INAOYL} -4-METHYL-2,3 -BENZOXAZIN-1-ONA; 6- {2- [2- (2,3-DIHYDRO-7-BENZOFURANIL) -2-METHYLPROPYL] -2-HYDROXY-3-OCTINYLAMINO} -4-METHYL-2,3-BENZOXAZIN-1-ONA; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE NON-STEROID MODULATORS OF PROGESTERONE RECEPTOR
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005030292A DE102005030292A1 (en) | 2005-06-24 | 2005-06-24 | Nonsteroidal progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070125A1 true PE20070125A1 (en) | 2007-02-14 |
Family
ID=37199176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000733A PE20070125A1 (en) | 2005-06-24 | 2006-06-26 | NON-STEROID PROGESTERONE RECEPTOR MODULATORS |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1902049A2 (en) |
| JP (1) | JP2008543910A (en) |
| KR (1) | KR20080030622A (en) |
| CN (1) | CN101248066A (en) |
| AR (1) | AR054519A1 (en) |
| AU (1) | AU2006261048A1 (en) |
| BR (1) | BRPI0611903A2 (en) |
| CA (1) | CA2611897A1 (en) |
| CR (1) | CR9598A (en) |
| DE (1) | DE102005030292A1 (en) |
| DO (1) | DOP2006000148A (en) |
| EA (1) | EA200702524A1 (en) |
| EC (1) | ECSP078044A (en) |
| GT (1) | GT200600271A (en) |
| IL (1) | IL188021A0 (en) |
| MX (1) | MX2008000072A (en) |
| NO (1) | NO20080440L (en) |
| PE (1) | PE20070125A1 (en) |
| TW (1) | TW200740778A (en) |
| UY (1) | UY29624A1 (en) |
| WO (1) | WO2006136461A2 (en) |
| ZA (1) | ZA200800690B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY30805A1 (en) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS |
| DE102007032800A1 (en) * | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| DE102007058747A1 (en) | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| WO2010002075A1 (en) * | 2008-07-02 | 2010-01-07 | Pharmacostech Co., Ltd. | Methods for preparing amide derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19856475A1 (en) * | 1998-11-27 | 2000-05-31 | Schering Ag | Nonsteroidal anti-inflammatories |
| EP1344776A1 (en) * | 2002-03-11 | 2003-09-17 | Schering Aktiengesellschaft | 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders |
| CA2531060A1 (en) * | 2003-07-01 | 2005-01-13 | Schering Aktiengesellschaft | Heterocyclically-substitued pentanol derivatives, process for their production and their use as anti-inflammatory agents |
-
2005
- 2005-06-24 DE DE102005030292A patent/DE102005030292A1/en not_active Ceased
-
2006
- 2006-06-22 AU AU2006261048A patent/AU2006261048A1/en not_active Abandoned
- 2006-06-22 CN CNA2006800308707A patent/CN101248066A/en active Pending
- 2006-06-22 JP JP2008517444A patent/JP2008543910A/en active Pending
- 2006-06-22 BR BRPI0611903-4A patent/BRPI0611903A2/en not_active Application Discontinuation
- 2006-06-22 MX MX2008000072A patent/MX2008000072A/en not_active Application Discontinuation
- 2006-06-22 CA CA002611897A patent/CA2611897A1/en not_active Abandoned
- 2006-06-22 KR KR1020087001793A patent/KR20080030622A/en not_active Application Discontinuation
- 2006-06-22 EP EP06762404A patent/EP1902049A2/en not_active Withdrawn
- 2006-06-22 EA EA200702524A patent/EA200702524A1/en unknown
- 2006-06-22 WO PCT/EP2006/006531 patent/WO2006136461A2/en active Application Filing
- 2006-06-23 TW TW095122742A patent/TW200740778A/en unknown
- 2006-06-26 PE PE2006000733A patent/PE20070125A1/en not_active Application Discontinuation
- 2006-06-26 UY UY29624A patent/UY29624A1/en not_active Application Discontinuation
- 2006-06-26 DO DO2006000148A patent/DOP2006000148A/en unknown
- 2006-06-27 AR ARP060102750A patent/AR054519A1/en unknown
- 2006-06-28 GT GT200600271A patent/GT200600271A/en unknown
-
2007
- 2007-12-10 IL IL188021A patent/IL188021A0/en unknown
- 2007-12-17 CR CR9598A patent/CR9598A/en not_active Application Discontinuation
- 2007-12-21 EC EC2007008044A patent/ECSP078044A/en unknown
-
2008
- 2008-01-23 ZA ZA200800690A patent/ZA200800690B/en unknown
- 2008-01-23 NO NO20080440A patent/NO20080440L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2611897A1 (en) | 2006-12-28 |
| UY29624A1 (en) | 2007-01-31 |
| NO20080440L (en) | 2008-03-25 |
| EP1902049A2 (en) | 2008-03-26 |
| AU2006261048A1 (en) | 2006-12-28 |
| GT200600271A (en) | 2007-02-05 |
| ECSP078044A (en) | 2008-01-23 |
| DOP2006000148A (en) | 2007-07-15 |
| IL188021A0 (en) | 2008-03-20 |
| AR054519A1 (en) | 2007-06-27 |
| EA200702524A1 (en) | 2008-06-30 |
| WO2006136461A2 (en) | 2006-12-28 |
| WO2006136461A3 (en) | 2007-03-15 |
| DE102005030292A1 (en) | 2007-01-11 |
| ZA200800690B (en) | 2009-09-30 |
| CN101248066A (en) | 2008-08-20 |
| CR9598A (en) | 2008-04-09 |
| KR20080030622A (en) | 2008-04-04 |
| BRPI0611903A2 (en) | 2010-10-05 |
| JP2008543910A (en) | 2008-12-04 |
| TW200740778A (en) | 2007-11-01 |
| MX2008000072A (en) | 2008-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |