PE20090477A1 - OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS - Google Patents

OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS

Info

Publication number
PE20090477A1
PE20090477A1 PE2008001166A PE2008001166A PE20090477A1 PE 20090477 A1 PE20090477 A1 PE 20090477A1 PE 2008001166 A PE2008001166 A PE 2008001166A PE 2008001166 A PE2008001166 A PE 2008001166A PE 20090477 A1 PE20090477 A1 PE 20090477A1
Authority
PE
Peru
Prior art keywords
alkyl
halo
inhibitors
methyl
dichlorophenyl
Prior art date
Application number
PE2008001166A
Other languages
Spanish (es)
Inventor
Yevgeni Besidski
Alf Claesson
Istvan Macsari
Lars Sandberg
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090477A1 publication Critical patent/PE20090477A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE OXAZOL DE FORMULA (I) DONDE R1 ES H, HALO, CN, ALQUILO(C1-C4), ENTRE OTROS; R2 Y R3 SON CADA UNO HALO, ALQUILO(C1-C4), ALQUENILO(C2-C4), CN, ENTRE OTROS; R4 ES H O ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO CON ALCOXI(C1-C3), HALO O CN; R5 ES HALOGENO, ALQUILO(C1-C4), CICLOALQUILO(C3-C6), CN, ENTRE OTROS; m ES DE 0 A 3; A ES NH U O; L ES ALQUILENO(C1-C4) OPCIONALMENTE SUSTITUIDO CON R6, EN DONDE R6 ES ALQUILO(C1-C4), ALQUENILO(C2-C4), FLUOROALQUILO(C1-C6), ENTRE OTROS; M ES ARILO(C6-C10) O HETEROARILO(C5-C10) OPCIONALMENTE SUSTITUIDO CON R7, EN DONDE R7 ES OH, HALO, CN, NITRO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[3-(2,6-DICLOROFENIL)-5-ETIL-1,2-OXAZOL-4-IL]CARBAMATO DE (2-CLORO-6-FLUORO-FENIL)METILO, N-[3-(2,6-DICLOROFENIL)-5-METIL-1,2-OXAZOL-4-IL]CARBAMATO DE (2-CLOROFENIL)METILO, N-[3-(2,6-DICLOROFENIL)-5-METIL-1,2-OXAZOL-4-IL]CARBAMATO DE (2,5-DICLOROFENIL)METILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LOS CANALES DE SODIO SIENDO UTILES EN EL TRATAMIENTO DEL DOLORREFERS TO COMPOUNDS DERIVED FROM OXAZOLE OF FORMULA (I) WHERE R1 IS H, HALO, CN, ALKYL (C1-C4), AMONG OTHERS; R2 AND R3 ARE EACH HALO, ALKYL (C1-C4), ALKENYL (C2-C4), CN, AMONG OTHERS; R4 IS H OR ALKYL (C1-C4) OPTIONALLY SUBSTITUTED WITH ALCOXY (C1-C3), HALO OR CN; R5 IS HALOGEN, ALKYL (C1-C4), CYCLOALKYL (C3-C6), CN, AMONG OTHERS; m IS 0 TO 3; A IS NH U O; L IS ALKYLENE (C1-C4) OPTIONALLY SUBSTITUTE WITH R6, WHERE R6 IS ALKYL (C1-C4), ALKYLENE (C2-C4), FLUOROALKYL (C1-C6), AMONG OTHERS; M IS ARYL (C6-C10) OR HETEROARILO (C5-C10) OPTIONALLY SUBSTITUTED WITH R7, WHERE R7 IS OH, HALO, CN, NITRO, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N- [3- (2,6-DICHLOROPHENYL) -5-ETHYL-1,2-OXAZOL-4-IL] (2-CHLORO-6-FLUORO-PHENYL) CARBAMATE, N- [3 - (2,6-DICHLOROPHENIL) -5-METHYL-1,2-OXAZOL-4-IL] (2-CHLOROPHENYL) METHYL CARBAMATE, N- [3- (2,6-DICHLOROPHENYL) -5-METHYL-1 , 2-OXAZOLE-4-IL] (2,5-DICHLOROPHENYL) METHYL CARBAMATE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF SODIUM CHANNELS, BEING USEFUL IN THE TREATMENT OF PAIN

PE2008001166A 2007-07-13 2008-07-11 OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS PE20090477A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94966507P 2007-07-13 2007-07-13

Publications (1)

Publication Number Publication Date
PE20090477A1 true PE20090477A1 (en) 2009-05-24

Family

ID=39709355

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001166A PE20090477A1 (en) 2007-07-13 2008-07-11 OXAZOLE DERIVATIVES AS INHIBITORS OF SODIUM CHANNELS

Country Status (6)

Country Link
AR (1) AR067513A1 (en)
CL (1) CL2008002038A1 (en)
PE (1) PE20090477A1 (en)
TW (1) TW200911766A (en)
UY (1) UY31219A1 (en)
WO (1) WO2009010784A1 (en)

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Publication number Priority date Publication date Assignee Title
SG188438A1 (en) * 2010-09-13 2013-05-31 Novartis Ag Triazine-oxadiazoles
JP6014155B2 (en) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． Biaryl ether sulfonamides and their use as therapeutic agents
KR20140091022A (en) 2011-10-31 2014-07-18 제논 파마슈티칼스 인크. Benzenesulfonamide compounds and their use as therapeutic agents
MX2014014234A (en) 2012-05-22 2015-05-07 Genentech Inc N-substituted benzamides and their use in the treatment of pain.
CA2878478A1 (en) 2012-07-06 2014-01-09 Genentech, Inc. N-substituted benzamides and methods of use thereof
WO2014153037A1 (en) 2013-03-14 2014-09-25 Genentech, Inc. Substituted triazolopyridines and methods of use thereof
RU2015143834A (en) 2013-03-15 2017-04-24 Дженентек, Инк. SUBSTITUTED BENZOXAZOLE AND METHODS OF USE
EP3074377B1 (en) 2013-11-27 2018-10-17 Genentech, Inc. Substituted benzamides and methods of use thereof
WO2015102929A1 (en) 2013-12-30 2015-07-09 Novartis Ag Tricyclic sulfonamide derivatives
CN106715418A (en) 2014-07-07 2017-05-24 基因泰克公司 Therapeutic compounds and methods of use thereof
MX2017014715A (en) 2015-05-22 2018-03-16 Genentech Inc Substituted benzamides and methods of use thereof.
JP2018526371A (en) 2015-08-27 2018-09-13 ジェネンテック， インコーポレイテッド Therapeutic compounds and methods of use thereof
CA2999769A1 (en) 2015-09-28 2017-04-06 Genentech, Inc. Therapeutic compounds and methods of use thereof
MA43304A (en) 2015-11-25 2018-10-03 Genentech Inc SUBSTITUTE BENZAMIDES USEFUL AS SODIUM CHANNEL BLOCKERS
EP3854782A1 (en) 2016-03-30 2021-07-28 Genentech, Inc. Substituted benzamides and methods of use thereof
SG11201903348UA (en) 2016-10-17 2019-05-30 Genentech Inc Therapeutic compounds and methods of use thereof
WO2018175707A1 (en) 2017-03-24 2018-09-27 Genentech, Inc. 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors
US11028075B2 (en) 2018-02-26 2021-06-08 Genentech, Inc. Therapeutic compounds and methods of use thereof
US10947251B2 (en) 2018-03-30 2021-03-16 Genentech, Inc. Therapeutic compounds and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075896A2 (en) * 2005-12-22 2007-07-05 Kemia, Inc. Heterocyclic cytokine inhibitors

Also Published As

Publication number Publication date
WO2009010784A1 (en) 2009-01-22
TW200911766A (en) 2009-03-16
UY31219A1 (en) 2009-03-02
CL2008002038A1 (en) 2009-07-17
AR067513A1 (en) 2009-10-14

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