DOP2006000148A - NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS - Google Patents

NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS

Info

Publication number
DOP2006000148A
DOP2006000148A DO2006000148A DO2006000148A DOP2006000148A DO P2006000148 A DOP2006000148 A DO P2006000148A DO 2006000148 A DO2006000148 A DO 2006000148A DO 2006000148 A DO2006000148 A DO 2006000148A DO P2006000148 A DOP2006000148 A DO P2006000148A
Authority
DO
Dominican Republic
Prior art keywords
prevention
compounds
progesterone receptors
hormone
therapy
Prior art date
Application number
DO2006000148A
Other languages
Spanish (es)
Inventor
Wolfgang Schwede
Norbert Schmmes
Alexander Hillisch
Carsten Moller
Ulrich Bothe
Ulrike Fuhrmann
Peter Droescher
Lothar Sobek
Guenter Kaufmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DOP2006000148A publication Critical patent/DOP2006000148A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion se refiere a moduladores no -esteroides de receptor de progesterona de la formula general a su use para la preparacion de medicamentos y a las composiciones farmaceuticas que contienen estos compuestos. Los compuestos de la invencion son apropiados para la terapia y la prevencion de enfermedades ginecologicas, como endome triosis, leiomiomas del utero, sangrados disfuncionales y dismenorrea y para el tratamiento y la prevencion de tumores hormona-dependientes y para el control de la fertilidad femenina, asi como para la terapia de sustitucion hormonal.The present invention relates to non-steroidal progesterone receptor modulators of the general formula for use in the preparation of medicaments and to pharmaceutical compositions containing these compounds. The compounds of the invention are suitable for the therapy and prevention of gynecological diseases, such as endome triosis, uterine leiomyomas, dysfunctional bleeding and dysmenorrhea and for the treatment and prevention of hormone-dependent tumors and for the control of female fertility, as well as for hormone replacement therapy.

DO2006000148A 2005-06-24 2006-06-26 NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS DOP2006000148A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005030292A DE102005030292A1 (en) 2005-06-24 2005-06-24 Nonsteroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
DOP2006000148A true DOP2006000148A (en) 2007-07-15

Family

ID=37199176

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2006000148A DOP2006000148A (en) 2005-06-24 2006-06-26 NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS

Country Status (22)

Country Link
EP (1) EP1902049A2 (en)
JP (1) JP2008543910A (en)
KR (1) KR20080030622A (en)
CN (1) CN101248066A (en)
AR (1) AR054519A1 (en)
AU (1) AU2006261048A1 (en)
BR (1) BRPI0611903A2 (en)
CA (1) CA2611897A1 (en)
CR (1) CR9598A (en)
DE (1) DE102005030292A1 (en)
DO (1) DOP2006000148A (en)
EA (1) EA200702524A1 (en)
EC (1) ECSP078044A (en)
GT (1) GT200600271A (en)
IL (1) IL188021A0 (en)
MX (1) MX2008000072A (en)
NO (1) NO20080440L (en)
PE (1) PE20070125A1 (en)
TW (1) TW200740778A (en)
UY (1) UY29624A1 (en)
WO (1) WO2006136461A2 (en)
ZA (1) ZA200800690B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (en) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS
DE102007032800A1 (en) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
DE102007058747A1 (en) * 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nonsteroidal progesterone receptor modulators
WO2010002075A1 (en) * 2008-07-02 2010-01-07 Pharmacostech Co., Ltd. Methods for preparing amide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19856475A1 (en) * 1998-11-27 2000-05-31 Schering Ag Nonsteroidal anti-inflammatories
EP1344776A1 (en) * 2002-03-11 2003-09-17 Schering Aktiengesellschaft 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders
BRPI0412231A (en) * 2003-07-01 2006-08-22 Schering Ag heterocyclically substituted pentanol derivatives, processes for their preparation and application as inflammation inhibitors

Also Published As

Publication number Publication date
BRPI0611903A2 (en) 2010-10-05
CA2611897A1 (en) 2006-12-28
PE20070125A1 (en) 2007-02-14
KR20080030622A (en) 2008-04-04
CR9598A (en) 2008-04-09
UY29624A1 (en) 2007-01-31
TW200740778A (en) 2007-11-01
JP2008543910A (en) 2008-12-04
MX2008000072A (en) 2008-03-24
AR054519A1 (en) 2007-06-27
WO2006136461A2 (en) 2006-12-28
WO2006136461A3 (en) 2007-03-15
NO20080440L (en) 2008-03-25
DE102005030292A1 (en) 2007-01-11
IL188021A0 (en) 2008-03-20
ZA200800690B (en) 2009-09-30
EA200702524A1 (en) 2008-06-30
ECSP078044A (en) 2008-01-23
EP1902049A2 (en) 2008-03-26
CN101248066A (en) 2008-08-20
GT200600271A (en) 2007-02-05
AU2006261048A1 (en) 2006-12-28

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