PE20060931A1 - Derivados de sulfonamida como moduladores de los receptores de glucocorticoides (gr) - Google Patents
Derivados de sulfonamida como moduladores de los receptores de glucocorticoides (gr)Info
- Publication number
- PE20060931A1 PE20060931A1 PE2005001261A PE2005001261A PE20060931A1 PE 20060931 A1 PE20060931 A1 PE 20060931A1 PE 2005001261 A PE2005001261 A PE 2005001261A PE 2005001261 A PE2005001261 A PE 2005001261A PE 20060931 A1 PE20060931 A1 PE 20060931A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- ilmethyl
- isoxazol
- methyl
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A DERIVADOS DE SULFONAMIDA DE FORMULA (I) DONDE R3 ES FENILO OPCIONALMENTE SUSTITUIDO, TIENILO, FURILO, ENTRE OTROS; L3 ES UN ENLACE, CH2; R1 ES H, ALQUILO (C1-C4); W ES FENILO, ISOXAZOLILO, PIRAZOLILO, ENTRE OTROS; L1 ES CH2; L2 ES O, NH, CH2NH, ENTRE OTROS; R2 ES CICLOHEXILO, FENILO, METILENDIOXIFENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-METOXI-2,3,6-TRIMETIL-N-(5-METIL-3-FENIL-ISOXAZOL-4-ILMETIL)-BENCENSULFONAMIDA, (5-METIL-3-FENIL-ISOXAZOL-4-ILMETIL)-AMIDA DEL ACIDO 4'-FLUORO-BIFENIL-4-SULFONICO, 4-(1,1-DIMETIL-PROPIL)-N-(5-METIL-3-FENIL-ISOXAZOL-4-ILMETIL)-BENCENSULFONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE GLUCOCORTICOIDES (GR) SIENDO UTILES COMO AGENTES ANTI-INFLAMATORIOS, ANTIALERGICOS, INMUNOSUPRESORES EN ENFERMEDADES TALES COMO ARTRITIS REUMATOIDE, PSORIASIS, RINITIS ALERGICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0402635A SE0402635D0 (sv) | 2004-10-29 | 2004-10-29 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060931A1 true PE20060931A1 (es) | 2006-10-13 |
Family
ID=33448752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001261A PE20060931A1 (es) | 2004-10-29 | 2005-10-28 | Derivados de sulfonamida como moduladores de los receptores de glucocorticoides (gr) |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20110130426A1 (es) |
| EP (1) | EP1807405A1 (es) |
| KR (1) | KR20070072550A (es) |
| CN (1) | CN101052627A (es) |
| AR (1) | AR051471A1 (es) |
| AU (1) | AU2005300148A1 (es) |
| BR (1) | BRPI0517259A (es) |
| CA (1) | CA2584409A1 (es) |
| EC (1) | ECSP077323A (es) |
| GT (1) | GT200500306A (es) |
| IL (1) | IL182424A0 (es) |
| MX (1) | MX2007004861A (es) |
| PA (1) | PA8651101A1 (es) |
| PE (1) | PE20060931A1 (es) |
| RS (1) | RS20070077A (es) |
| RU (1) | RU2007115548A (es) |
| SE (1) | SE0402635D0 (es) |
| TW (1) | TW200630352A (es) |
| UY (1) | UY29181A1 (es) |
| WO (1) | WO2006046914A1 (es) |
| ZA (1) | ZA200703389B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200800150A (en) * | 2005-12-21 | 2008-01-01 | Organon Nv | Compounds with medicinal effects due to interaction with the glucocorticoid receptor |
| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| MX2010011258A (es) | 2008-04-14 | 2011-06-20 | Univ Texas | Inhibidores de molecula pequeña del dominio de homologia de pleckstrin y metodos para usar los mismos. |
| SA109300309B1 (ar) | 2008-05-20 | 2013-01-22 | باير شيرنج فارما ايه جي | مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| ES2645617T3 (es) | 2012-02-29 | 2017-12-07 | Chemocentryx, Inc. | Pirazol-1-il benceno sulfonamidas como antagonistas del CCR9 |
| JP6357292B2 (ja) | 2012-12-14 | 2018-07-11 | フューシス セラピューティクス、インク． | Ｃｎｋｓｒ１を阻害するための方法及び組成物 |
| IL292655B2 (en) | 2014-10-06 | 2024-03-01 | Chemocentryx Inc | CCR9 chemokine receptor inhibitor for use in a method for treating or reducing the development of inflammatory bowel diseases |
| US10227317B2 (en) | 2015-02-25 | 2019-03-12 | Lupin Limited | Process for the preparation of vortioxetine |
| US10227356B2 (en) | 2015-04-20 | 2019-03-12 | Phusis Therapeutics, Inc. | Compounds, compositions and methods for inhibiting CNKSR1 |
| UA127357C2 (uk) | 2018-04-18 | 2023-07-26 | Констеллатіон Фармацеутікалс, Інк. | Модулятори метилмодифікуючих ферментів, композиції та їх використання |
| CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US10792360B1 (en) | 2019-11-21 | 2020-10-06 | Chemocentryx, Inc. | Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-TNF-alpha blocking antibodies |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US444347A (en) * | 1891-01-06 | James | ||
| US3992441A (en) * | 1972-12-26 | 1976-11-16 | Pfizer Inc. | Sulfamylbenzoic acids |
| DE3535167A1 (de) * | 1985-10-02 | 1987-04-09 | Boehringer Mannheim Gmbh | Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel |
| DE3632329A1 (de) * | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| US5545669A (en) * | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
| AU5772296A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| TW523506B (en) * | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
| AU759255B2 (en) * | 1998-01-29 | 2003-04-10 | Amgen, Inc. | PPAR-gamma modulators |
| US6569885B1 (en) * | 1999-12-23 | 2003-05-27 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| CN1582281A (zh) * | 2001-10-01 | 2005-02-16 | 大正制药株式会社 | Mch受体拮抗剂 |
| AU2003248549B2 (en) * | 2002-05-24 | 2010-04-08 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
| CA2515780C (en) * | 2003-02-20 | 2012-12-11 | Encysive Pharmaceuticals Inc. | Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists |
| US7393873B2 (en) * | 2003-07-02 | 2008-07-01 | Merck & Co., Inc. | Arylsulfonamide derivatives |
| WO2005086904A2 (en) * | 2004-03-08 | 2005-09-22 | Amgen Inc. | Therapeutic modulation of ppar (gamma) activity |
-
2004
- 2004-10-29 SE SE0402635A patent/SE0402635D0/xx unknown
-
2005
- 2005-10-26 US US11/718,203 patent/US20110130426A1/en not_active Abandoned
- 2005-10-26 RS RSP-2007/0077A patent/RS20070077A/sr unknown
- 2005-10-26 BR BRPI0517259-4A patent/BRPI0517259A/pt not_active Application Discontinuation
- 2005-10-26 CA CA002584409A patent/CA2584409A1/en not_active Abandoned
- 2005-10-26 WO PCT/SE2005/001608 patent/WO2006046914A1/en active Application Filing
- 2005-10-26 RU RU2007115548/04A patent/RU2007115548A/ru unknown
- 2005-10-26 AU AU2005300148A patent/AU2005300148A1/en not_active Abandoned
- 2005-10-26 CN CNA2005800375054A patent/CN101052627A/zh active Pending
- 2005-10-26 KR KR1020077009608A patent/KR20070072550A/ko not_active Application Discontinuation
- 2005-10-26 EP EP05797057A patent/EP1807405A1/en not_active Withdrawn
- 2005-10-26 MX MX2007004861A patent/MX2007004861A/es not_active Application Discontinuation
- 2005-10-27 AR ARP050104506A patent/AR051471A1/es not_active Application Discontinuation
- 2005-10-27 GT GT200500306A patent/GT200500306A/es unknown
- 2005-10-28 UY UY29181A patent/UY29181A1/es not_active Application Discontinuation
- 2005-10-28 TW TW094137740A patent/TW200630352A/zh unknown
- 2005-10-28 PA PA20058651101A patent/PA8651101A1/es unknown
- 2005-10-28 PE PE2005001261A patent/PE20060931A1/es not_active Application Discontinuation
-
2007
- 2007-03-14 EC EC2007007323A patent/ECSP077323A/es unknown
- 2007-04-10 IL IL182424A patent/IL182424A0/en unknown
- 2007-04-25 ZA ZA200703389A patent/ZA200703389B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GT200500306A (es) | 2006-06-06 |
| UY29181A1 (es) | 2006-05-31 |
| CN101052627A (zh) | 2007-10-10 |
| AU2005300148A1 (en) | 2006-05-04 |
| EP1807405A1 (en) | 2007-07-18 |
| BRPI0517259A (pt) | 2008-10-07 |
| ZA200703389B (en) | 2009-12-30 |
| PA8651101A1 (es) | 2006-06-02 |
| MX2007004861A (es) | 2007-05-09 |
| US20110130426A1 (en) | 2011-06-02 |
| AR051471A1 (es) | 2007-01-17 |
| RS20070077A (en) | 2008-09-29 |
| RU2007115548A (ru) | 2008-12-10 |
| TW200630352A (en) | 2006-09-01 |
| SE0402635D0 (sv) | 2004-10-29 |
| ECSP077323A (es) | 2007-04-26 |
| CA2584409A1 (en) | 2006-05-04 |
| IL182424A0 (en) | 2007-07-24 |
| WO2006046914A1 (en) | 2006-05-04 |
| KR20070072550A (ko) | 2007-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |