PE20060724A1 - Compuestos derivados de amidas como inhibidores de la proteina tirosina quinasa - Google Patents

Compuestos derivados de amidas como inhibidores de la proteina tirosina quinasa

Info

Publication number
PE20060724A1
PE20060724A1 PE2005001242A PE2005001242A PE20060724A1 PE 20060724 A1 PE20060724 A1 PE 20060724A1 PE 2005001242 A PE2005001242 A PE 2005001242A PE 2005001242 A PE2005001242 A PE 2005001242A PE 20060724 A1 PE20060724 A1 PE 20060724A1
Authority
PE
Peru
Prior art keywords
phenyl
methyl
tyrosine kinase
cyano
amide
Prior art date
Application number
PE2005001242A
Other languages
English (en)
Inventor
Carl Illig
Shelley Ballentine
Jinsheng Chen
M Jonathan Rudolph
Ken Wilson
Christopher J Molloy
Christopher Flores
Carl Manthey
Renee Desjarlais
Mark Wall
Sanath Meegalla
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20060724A1 publication Critical patent/PE20060724A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE A ES FENILO, PIRIDILO; W ES PIRROLILO, IMIDAZOLILO, ISOXAZOLILO, ENTRE OTROS; R2 ES TIOFENILO, DIHIDROSULFONOPIRANILO, FENILO, ENTRE OTROS; X ES EL COMPUESTO DE FORMULA II, III, ENTRE OTROS; DONDE D1 Y D2 SON H; Ra Y Rb SON H, ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: [4-(4-METIL-PIPERAZIN-1-IL)-2-(3-METIL-TIOFEN-2-IL)-FENIL]-AMIDA DEL ACIDO CIANO-FURAN-2-CARBOXILICO, [4-(4-METIL-PIPERAZIN-1-IL)-2-(2-METIL-TIOFEN-3-IL)-FENIL]-AMIDA DEL ACIDO 5-CIANO-FURAN-2-CARBOXILICO, [4-(1-ACETIL-PIPERIDIN-4-IL)-2-(1,2,5,6-TETRAHIDRO-PIRIDIN-3-IL)-FENIL]-AMIDA DEL ACIDO 4-CIANO-1H-IMIDAZOL-2-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA TIROSINA QUINASA Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES, METASTASIS DE CANCER OVARICO, CANCER DE UTERO
PE2005001242A 2004-10-22 2005-10-21 Compuestos derivados de amidas como inhibidores de la proteina tirosina quinasa PE20060724A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62121104P 2004-10-22 2004-10-22
US67017205P 2005-04-11 2005-04-11
US11/254,276 US7662837B2 (en) 2004-10-22 2005-10-20 Inhibitors of c-fms kinase

Publications (1)

Publication Number Publication Date
PE20060724A1 true PE20060724A1 (es) 2006-09-01

Family

ID=40433511

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001242A PE20060724A1 (es) 2004-10-22 2005-10-21 Compuestos derivados de amidas como inhibidores de la proteina tirosina quinasa

Country Status (10)

Country Link
US (1) US7662837B2 (es)
AR (1) AR051599A1 (es)
EC (1) ECSP077409A (es)
IL (1) IL182735A (es)
MY (1) MY145668A (es)
NZ (1) NZ555289A (es)
PE (1) PE20060724A1 (es)
SV (1) SV2006002669A (es)
TW (1) TWI377942B (es)
UY (1) UY29178A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7645755B2 (en) * 2004-10-22 2010-01-12 Janssen Pharmaceutical N.V. Inhibitors of c-fms kinase
US20060281788A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
CA2649924C (en) 2006-04-20 2014-08-19 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
EP2021329B1 (en) * 2006-04-20 2016-04-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
MX2008013533A (es) 2006-04-20 2009-01-15 Janssen Pharmaceutica Nv Compuestos heterociclicos como inhibidores de c-fms cinasa.
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
AU2013299922B2 (en) 2012-08-07 2018-06-21 Janssen Pharmaceutica Nv Process for the preparation of heterocyclic ester derivatives
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد

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Publication number Priority date Publication date Assignee Title
US5190541A (en) * 1990-10-17 1993-03-02 Boston Scientific Corporation Surgical instrument and method
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
US5702390A (en) * 1996-03-12 1997-12-30 Ethicon Endo-Surgery, Inc. Bioplar cutting and coagulation instrument
UA59384C2 (uk) 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
US6100254A (en) * 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
WO2000042042A2 (en) * 1999-01-11 2000-07-20 Princeton University High affinity inhibitors for target validation and uses thereof
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
ES2391550T3 (es) * 1999-04-15 2012-11-27 Bristol-Myers Squibb Company Inhibidores cíclicos de la proteína tirosina quinasa
US6346625B1 (en) * 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
CA2394727A1 (en) 1999-12-28 2001-07-05 Pharmacopeia, Inc. Pyrimidine and triazine kinase inhibitors
US6558385B1 (en) 2000-09-22 2003-05-06 Tissuelink Medical, Inc. Fluid-assisted medical device
US6692491B1 (en) * 2000-03-24 2004-02-17 Scimed Life Systems, Inc. Surgical methods and apparatus for positioning a diagnostic or therapeutic element around one or more pulmonary veins or other body structures
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CA2521830A1 (en) * 2003-04-09 2004-10-21 Japan Tobacco Inc. Heteroaromatic pentacyclic compound and medicinal use thereof
MXPA05011503A (es) * 2003-04-25 2006-05-31 Johnson & Johnson Inhibidores de la c-fms cinasa.
US7645755B2 (en) * 2004-10-22 2010-01-12 Janssen Pharmaceutical N.V. Inhibitors of c-fms kinase

Also Published As

Publication number Publication date
SV2006002669A (es) 2009-10-15
TW200630092A (en) 2006-09-01
TWI377942B (en) 2012-12-01
MY145668A (en) 2012-03-15
IL182735A (en) 2013-10-31
US7662837B2 (en) 2010-02-16
US20060148812A1 (en) 2006-07-06
IL182735A0 (en) 2007-09-20
ECSP077409A (es) 2007-05-30
AR051599A1 (es) 2007-01-24
NZ555289A (en) 2010-10-29
UY29178A1 (es) 2006-03-31

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