PE20060123A1 - DERIVATIVES OF PHENYLETHANOLAMINE AS ß-2 AGONISTS - Google Patents

DERIVATIVES OF PHENYLETHANOLAMINE AS ß-2 AGONISTS

Info

Publication number
PE20060123A1
PE20060123A1 PE2005000297A PE2005000297A PE20060123A1 PE 20060123 A1 PE20060123 A1 PE 20060123A1 PE 2005000297 A PE2005000297 A PE 2005000297A PE 2005000297 A PE2005000297 A PE 2005000297A PE 20060123 A1 PE20060123 A1 PE 20060123A1
Authority
PE
Peru
Prior art keywords
phenyl
hydroxy
alkyl
phenylethanolamine
agonists
Prior art date
Application number
PE2005000297A
Other languages
Spanish (es)
Inventor
Alan Daniel Brown
Mark Edward Bunnage
Charlotte Alice Louise Lane
Graham Lunn
David Anthony Price
Russell Andrew Lewthwaite
Paul Alan Glossop
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04290725A external-priority patent/EP1577291A1/en
Priority claimed from GB0425064A external-priority patent/GB0425064D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of PE20060123A1 publication Critical patent/PE20060123A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REIERE A DERIVADOS DE FENILETANOLAMINA DE FORMULA (I), EN DONDE EL GRUPO (CH2)n-C(=O)Q1 ESTA EN POSICION RELATIVA META O PARA; R1 Y R2 SON INDEPENDIENTEMENTE H O ALQUILO(C1-C4); n ES DE 0 A 2; Q1 ES UN GRUPO a), b), c), -NH-ALQUILO(C1-C4) O -N(R8)-Q2-A, EN DONDE Q2 ES UN ENLACE SENCILLO O ALQUILENO(C1-C4); R8 ES H O ALQUILO(C1-C4); p ES 1 O 2; A ES CICLOALQUILO (C3-C10), O-FENILPIRAZOLILO, UN HETEROCICLICO DE 5 A 10 MIEMBROS, O NAFTALENIL O FENIL, OPCIONALMENTE SUSTITUIDOS. SON COMPUESTOS PREFERIDOS: N-CICLOHEPTIL-2-{3-[(2R)-2-({(2R)-2-HIDROXI-2-[4-HIDROXI-3-(HIDROXIMETIL)FENIL]ETIL}AMINO)PROPIL}FENIL]-ACETAMIDA, N-(3,4-DICLOROBENCIL)-3-{3-[2-({(2R)-2-HIDROXI-2-[4-HIDROXI-3-(HIDROXIMETIL)FENIL]ETIL}AMINO)-2-METILPROPIL]-FENIL}PROPANAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON AGONISTAS DE RECEPTORES ADRENERGICOS ß2, POR LO QUE SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES Y TRANSTORNOS INFLAMATORIOS, ALERGICOS Y RESPIRATORIOSREFERS TO DERIVATIVES OF PHENYLETHANOLAMINE OF FORMULA (I), WHERE THE GROUP (CH2) n-C (= O) Q1 IS IN A RELATIVE POSITION TARGET OR FOR; R1 AND R2 ARE INDEPENDENTLY H OR ALKYL (C1-C4); n IS 0 TO 2; Q1 IS A GROUP a), b), c), -NH-ALKYL (C1-C4) OR -N (R8) -Q2-A, WHERE Q2 IS A SINGLE OR ALKYLENE (C1-C4) LINK; R8 IS HO (C1-C4) ALKYL; p IS 1 O 2; A IS CYCLOALKYL (C3-C10), O-PHENYLPIRAZOLYL, A 5-10 MEMBER HETEROCYCLIC, OR NAPHTHALENIL OR PHENYL, OPTIONALLY SUBSTITUTED. PREFERRED COMPOUNDS ARE: N-CYCLOHEPTIL-2- {3 - [(2R) -2 - ({(2R) -2-HYDROXY-2- [4-HYDROXY-3- (HYDROXIMETHYL) PHENYL] ETHYL} AMINO) PROPYL} PHENYL] -ACETAMIDE, N- (3,4-DICHLOROBENZYL) -3- {3- [2 - ({(2R) -2-HYDROXY-2- [4-HYDROXY-3- (HYDROXIMETHYL) PHENYL] ETHYL} AMINO ) -2-METHYLPROPYL] -PHENYL} PROPANAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE AGONISTS OF ß2-ADRENERGIC RECEPTORS, SO THEY ARE USEFUL FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY DISEASES AND DISORDERS

PE2005000297A 2004-03-17 2005-03-15 DERIVATIVES OF PHENYLETHANOLAMINE AS ß-2 AGONISTS PE20060123A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04290725A EP1577291A1 (en) 2004-03-17 2004-03-17 Phenylethanolamine derivatives as beta-2 agonists
US59179004P 2004-07-27 2004-07-27
GB0425064A GB0425064D0 (en) 2004-11-12 2004-11-12 Compounds useful for the treatment of diseases

Publications (1)

Publication Number Publication Date
PE20060123A1 true PE20060123A1 (en) 2006-03-08

Family

ID=34961252

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000297A PE20060123A1 (en) 2004-03-17 2005-03-15 DERIVATIVES OF PHENYLETHANOLAMINE AS ß-2 AGONISTS

Country Status (13)

Country Link
KR (1) KR20070026420A (en)
AP (1) AP2006003743A0 (en)
AR (1) AR048267A1 (en)
EC (1) ECSP066854A (en)
IL (1) IL177754A0 (en)
MA (1) MA28475B1 (en)
NL (1) NL1028559C2 (en)
NO (1) NO20063875L (en)
PA (1) PA8626401A1 (en)
PE (1) PE20060123A1 (en)
SV (1) SV2005002052A (en)
TW (1) TWI281396B (en)
UY (1) UY28810A1 (en)

Also Published As

Publication number Publication date
KR20070026420A (en) 2007-03-08
NL1028559C2 (en) 2006-04-19
ECSP066854A (en) 2006-11-24
PA8626401A1 (en) 2006-05-16
IL177754A0 (en) 2006-12-31
SV2005002052A (en) 2005-12-13
UY28810A1 (en) 2005-10-31
TW200534846A (en) 2005-11-01
AR048267A1 (en) 2006-04-12
MA28475B1 (en) 2007-03-01
NO20063875L (en) 2006-09-26
NL1028559A1 (en) 2005-09-20
AP2006003743A0 (en) 2006-10-31
TWI281396B (en) 2007-05-21

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