PE20091092A1 - HETEROCYCLIC COMPOUNDS AS INHIBITORS OF THE HEDGEHOG PATH - Google Patents
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF THE HEDGEHOG PATHInfo
- Publication number
- PE20091092A1 PE20091092A1 PE2008001563A PE2008001563A PE20091092A1 PE 20091092 A1 PE20091092 A1 PE 20091092A1 PE 2008001563 A PE2008001563 A PE 2008001563A PE 2008001563 A PE2008001563 A PE 2008001563A PE 20091092 A1 PE20091092 A1 PE 20091092A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- inhibitors
- carboxamide
- pyridin
- trifluoromethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO HETEROCICLICO DE FORMULA (I), DONDE R1, R2 Y R3 SON H, HALOGENO O ALQUILO C1-C6; R4 ES HALOGENO, ALQUILO C1-C6 O HALOALQUILO C1-C6; W ES N, O, S, CR5, ENTRE OTROS; R5 ES H, ALCOXILO C1-C6, ALQUILO C1-C6, ENTRE OTROS; A ES N, CR6, NR6, N, O, S; R6 ES H, ALCOXILO C1-C6, AMINO, AMIDO, ENTRE OTROS; q Y p SON 0 O 1. SON COMPUESTOS PREFERIDOS: N-[4-CLORO-3-(1,5-DIMETIL-1H-IMIDAZOL-2-IL)FENIL]-2-METIL-6-(TRIFLUOROMETIL)PIRIDIN-3-CARBOXAMIDA, N-[4-CLORO-3-(1-METIL-1H-IMIDAZOL-2-IL)FENIL]-2-METIL-6-(TRIFLUOROMETIL)PIRIDIN-3-CARBOXAMIDA, N-[3-(5-AMINOPIRAZIN-2-IL)-4-CLOROFENIL]-2-METIL-6-(TRIFLUOROMETIL)PIRIDIN-3-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA VIA HEDGEHOG Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS CELULARESREFERRING TO A HETEROCYCLIC DERIVATIVE COMPOUND OF FORMULA (I), WHERE R1, R2 AND R3 ARE H, HALOGEN OR C1-C6 ALKYL; R4 IS HALOGEN, C1-C6 ALKYL OR C1-C6 HALOALKYL; W IS N, O, S, CR5, AMONG OTHERS; R5 IS H, C1-C6 ALCOXYL, C1-C6 ALKYL, AMONG OTHERS; A IS N, CR6, NR6, N, O, S; R6 IS H, C1-C6 ALCOXYL, AMINO, AMIDO, AMONG OTHERS; q AND p ARE 0 OR 1. THE PREFERRED COMPOUNDS ARE: N- [4-CHLORO-3- (1,5-DIMETHYL-1H-IMIDAZOL-2-IL) PHENYL] -2-METHYL-6- (TRIFLUOROMETHYL) PYRIDIN- 3-CARBOXAMIDE, N- [4-CHLORO-3- (1-METHYL-1H-IMIDAZOL-2-IL) PHENYL] -2-METHYL-6- (TRIFLUOROMETHYL) PYRIDIN-3-CARBOXAMIDE, N- [3- ( 5-AMINOPYRAZIN-2-IL) -4-CHLOROPHENYL] -2-METHYL-6- (TRIFLUOROMETHYL) PYRIDIN-3-CARBOXAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF THE HEDGEHOG PATHWAY AND ARE USEFUL IN THE TREATMENT OF PROLIFERATIVE CELLULAR DISEASES
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97010707P | 2007-09-05 | 2007-09-05 | |
US3666108P | 2008-03-14 | 2008-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091092A1 true PE20091092A1 (en) | 2009-08-27 |
Family
ID=39938463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001563A PE20091092A1 (en) | 2007-09-05 | 2008-09-05 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF THE HEDGEHOG PATH |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR068376A1 (en) |
PE (1) | PE20091092A1 (en) |
TW (1) | TW200916458A (en) |
UY (1) | UY31322A1 (en) |
WO (1) | WO2009030952A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010144586A1 (en) * | 2009-06-09 | 2010-12-16 | Abraxis Bioscience, Llc | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling |
JP2013516480A (en) * | 2010-01-07 | 2013-05-13 | セレクサゲン セラピューティクス,インク. | Hedgehog inhibitor |
WO2011095807A1 (en) * | 2010-02-07 | 2011-08-11 | Astrazeneca Ab | Combinations of mek and hh inhibitors |
CN101993415B (en) * | 2010-09-15 | 2013-08-14 | 北京韩美药品有限公司 | Compound as Hedgehog path inhibitor, medicine composition containing same and application thereof |
CN103570625A (en) * | 2012-07-19 | 2014-02-12 | 南京英派药业有限公司 | N-(3-aryl-heteroaryl)-4-aryl-aryl carboxamide and analog as hedgehog pathway inhibitors and application thereof |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
UY36294A (en) | 2014-09-12 | 2016-04-29 | Novartis Ag | COMPOUNDS AND COMPOSITIONS AS QUINASA INHIBITORS |
AU2017329090B9 (en) | 2016-09-19 | 2019-09-05 | Novartis Ag | Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor |
WO2018082587A1 (en) * | 2016-11-04 | 2018-05-11 | 上海瑛派药业有限公司 | Application of hedgehog pathway inhibitor for treatment of fibrotic diseases |
JP7309614B2 (en) | 2017-05-02 | 2023-07-18 | ノバルティス アーゲー | combination therapy |
CN107281214A (en) * | 2017-06-06 | 2017-10-24 | 北京工业大学 | Hydrogen molecule liquid/gas is preparing the application in suppressing tumor stem cell medicine |
CN109369634B (en) * | 2018-12-19 | 2021-07-27 | 陕西国际商贸学院 | Preparation method and application of 2-methoxynicotinamide derivative with antitumor activity |
AU2022295990A1 (en) | 2021-06-18 | 2024-01-04 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE485275T1 (en) * | 2002-02-12 | 2010-11-15 | Glaxosmithkline Llc | NICOTINAMIDES AND THEIR USE AS P38 INHIBITORS |
EP1496905B1 (en) * | 2002-04-22 | 2008-08-13 | Johns Hopkins University School of Medicine | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
US8273743B2 (en) * | 2004-04-30 | 2012-09-25 | Curis, Inc. | Quinoxaline inhibitors of the hedgehog signalling |
KR20140048343A (en) * | 2004-09-02 | 2014-04-23 | 제넨테크, 인크. | Pyridyl inhibitors of hedgehog signalling |
WO2006050506A1 (en) * | 2004-11-03 | 2006-05-11 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
JP2009511559A (en) * | 2005-10-12 | 2009-03-19 | バイオリポックス エービー | Benzoxazoles useful for the treatment of inflammation |
PE20080948A1 (en) * | 2006-07-25 | 2008-09-10 | Irm Llc | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE HEDGEHOG PATH |
-
2008
- 2008-09-04 TW TW097133986A patent/TW200916458A/en unknown
- 2008-09-04 UY UY31322A patent/UY31322A1/en unknown
- 2008-09-04 WO PCT/GB2008/050782 patent/WO2009030952A2/en active Application Filing
- 2008-09-05 PE PE2008001563A patent/PE20091092A1/en not_active Application Discontinuation
- 2008-09-05 AR ARP080103877A patent/AR068376A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR068376A1 (en) | 2009-11-11 |
TW200916458A (en) | 2009-04-16 |
UY31322A1 (en) | 2009-04-30 |
WO2009030952A2 (en) | 2009-03-12 |
WO2009030952A3 (en) | 2009-05-07 |
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