AR048267A1 - USEFUL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS - Google Patents

USEFUL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS

Info

Publication number
AR048267A1
AR048267A1 ARP050101000A ARP050101000A AR048267A1 AR 048267 A1 AR048267 A1 AR 048267A1 AR P050101000 A ARP050101000 A AR P050101000A AR P050101000 A ARP050101000 A AR P050101000A AR 048267 A1 AR048267 A1 AR 048267A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
phenyl
atoms
cycloalkyl
Prior art date
Application number
ARP050101000A
Other languages
Spanish (es)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04290725A external-priority patent/EP1577291A1/en
Priority claimed from GB0425064A external-priority patent/GB0425064D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of AR048267A1 publication Critical patent/AR048267A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuestos utiles para el tratamiento de afecciones inflamatorias, alérgicas y respiratorias. Reivindicacion 1: Un compuesto de la formula (1) en el que el grupo (CH2)n-C(=O)Q1 está en posicion relativa meta o para, R1 y R2 se seleccionan independientemente de H y alquilo C1-4, n es 0, 1 o 2, y Q1 es un grupo que se selecciona de: los restos de formulas (2), *-NH-alquilo C1-4 y un grupo *-N(R8)-Q2-A, en el que Q2 es un enlace sencillo o un alquileno C1-4, R8 es H o alquilo C1-4, p es 1 o 2, y A es un cicloalquilo C3-10, estando 2 átomos de C o más de dicho cicloalquilo opcionalmente punteados por uno o más átomos de C, preferiblemente por 1, 2, 3 o 4 átomos de C, O-fenilpirazolilo, un grupo heterocíclico de 5 a 10 miembros, opcionalmente aromático, que comprende 1, 2, 3 o 4 heteroátomos que se seleccionan de O, S o N, opcionalmente sustituidos con alquilo C1-4 u O-alquilo C1-4 o un grupo de la formula (3), R3, R4, R5, R6 y R7 son iguales o diferentes y se seleccionan de H, alquilo C1-4, OR9, SR9, SOR9, SO2R9, halo, CN, CF3, OCF3, fenilo, O-fenilo, S-fenilo, SO2-morfolinilo, O-(CH2)3-pirrolidinilo, COOR9, SO2NR9R10, CONR9R10, NR9R10 y NHCOR10; R9 y R10 son iguales o diferentes y se seleccionan de H o alquilo C1-4 y el * representa el punto de union al grupo carbonilo; o, si fuera apropiado, sus sales y/o isomeros, tautomeros, solvatos o variaciones isotopicas de los mismos farmacéuticamente aceptables, con la condicion de que cuando n es 0, entonces Q1 no es -NHCH3 y, cuando n es 1 o 2, entonces: 1) Q1 es *-NH-alquilo C1-4 o *-N(R8)-Q2-A, en el que A es cicloalquilo C3-10, estando 2 átomos de C o más de dicho cicloalquilo opcionalmente puenteado por 1, o más átomos de C, O-fenilpirazolilo, grupo heterocíclico de 5 a 10 miembros, opcionalmente aromático, que comprende 1, 2, 3 o 4 heteroátomos que se seleccionan de O, S, o N, opcionalmente sustituidos con alquilo C1-4 u O-alquilo C1-4, siendo dicho grupo heterocíclico distinto de piridilo, un grupo de la formula (3) en el que uno de R3 a R7 es CN, SOR9, SO2R9, fenilo, O-fenilo, S-fenilo, SO2-morfolinilo u O-(CH2)3-pirrolidinilo y/o 2) cuando uno de R1 y R2 es H, el otro no es CH3.Useful compounds for the treatment of inflammatory, allergic and respiratory conditions. Claim 1: A compound of the formula (1) in which the group (CH2) nC (= O) Q1 is in a relative meta or para position, R1 and R2 are independently selected from H and C1-4 alkyl, n is 0 , 1 or 2, and Q1 is a group selected from: the residues of formulas (2), * -NH-C1-4 alkyl and a group * -N (R8) -Q2-A, in which Q2 is a single bond or a C1-4 alkylene, R8 is H or C1-4 alkyl, p is 1 or 2, and A is a C3-10 cycloalkyl, with 2 C atoms or more of said cycloalkyl optionally dotted by one or more C atoms, preferably 1, 2, 3 or 4 C atoms, O-phenylpyrazolyl, a 5-10 membered heterocyclic group, optionally aromatic, comprising 1, 2, 3 or 4 heteroatoms selected from O, S or N, optionally substituted with C1-4 alkyl or O-C1-4 alkyl or a group of the formula (3), R3, R4, R5, R6 and R7 are the same or different and are selected from H, C1-4 alkyl , OR9, SR9, SOR9, SO2R9, halo, CN, CF3, OCF3, phenyl, O-phenyl, S-phenyl, SO2-morfoli nyl, O- (CH2) 3-pyrrolidinyl, COOR9, SO2NR9R10, CONR9R10, NR9R10 and NHCOR10; R9 and R10 are the same or different and are selected from H or C1-4 alkyl and * represents the point of attachment to the carbonyl group; or, if appropriate, its salts and / or isomers, tautomers, solvates or pharmaceutically acceptable isotopic variations thereof, with the proviso that when n is 0, then Q1 is not -NHCH3 and, when n is 1 or 2, then: 1) Q1 is * -NH-C1-4 alkyl or * -N (R8) -Q2-A, wherein A is C3-10 cycloalkyl, 2 atoms of C or more of said cycloalkyl being optionally bridged by 1 , or more C, O-phenylpyrazyl, 5 to 10 membered heterocyclic group, optionally aromatic, comprising 1, 2, 3 or 4 heteroatoms that are selected from O, S, or N, optionally substituted with C1-4 alkyl or O-C 1-4 alkyl, said heterocyclic group being different from pyridyl, a group of the formula (3) in which one of R 3 to R 7 is CN, SOR9, SO2R9, phenyl, O-phenyl, S-phenyl, SO2 -morpholinyl or O- (CH2) 3-pyrrolidinyl and / or 2) when one of R1 and R2 is H, the other is not CH3.

ARP050101000A 2004-03-17 2005-03-15 USEFUL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS AR048267A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04290725A EP1577291A1 (en) 2004-03-17 2004-03-17 Phenylethanolamine derivatives as beta-2 agonists
US59179004P 2004-07-27 2004-07-27
GB0425064A GB0425064D0 (en) 2004-11-12 2004-11-12 Compounds useful for the treatment of diseases

Publications (1)

Publication Number Publication Date
AR048267A1 true AR048267A1 (en) 2006-04-12

Family

ID=34961252

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101000A AR048267A1 (en) 2004-03-17 2005-03-15 USEFUL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS

Country Status (13)

Country Link
KR (1) KR20070026420A (en)
AP (1) AP2006003743A0 (en)
AR (1) AR048267A1 (en)
EC (1) ECSP066854A (en)
IL (1) IL177754A0 (en)
MA (1) MA28475B1 (en)
NL (1) NL1028559C2 (en)
NO (1) NO20063875L (en)
PA (1) PA8626401A1 (en)
PE (1) PE20060123A1 (en)
SV (1) SV2005002052A (en)
TW (1) TWI281396B (en)
UY (1) UY28810A1 (en)

Also Published As

Publication number Publication date
ECSP066854A (en) 2006-11-24
IL177754A0 (en) 2006-12-31
TW200534846A (en) 2005-11-01
NO20063875L (en) 2006-09-26
SV2005002052A (en) 2005-12-13
NL1028559A1 (en) 2005-09-20
TWI281396B (en) 2007-05-21
MA28475B1 (en) 2007-03-01
PE20060123A1 (en) 2006-03-08
KR20070026420A (en) 2007-03-08
PA8626401A1 (en) 2006-05-16
AP2006003743A0 (en) 2006-10-31
NL1028559C2 (en) 2006-04-19
UY28810A1 (en) 2005-10-31

Similar Documents

Publication Publication Date Title
CO5720993A2 (en) SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES
AR044475A1 (en) DERIVATIVES OF 2-AMINO-PYRIDINE USEFUL FOR THE TREATMENT OF DISEASES
AR047509A1 (en) SULFONAMIDE DERIVATIVES AS BETA2 ADRENERGIC RECEIVERS ANTAGONISTS
AR044476A1 (en) USED 2-AMINO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES
AR058546A1 (en) DERIVATIVES OF 2- ADAMANTILUREA AS SELECTIVE INHIBITORS OF 11 BETA - HSD1
RS53108B (en) Amino 1,3,5-triazines n-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof and their use as herbicides and plant growth regulators
AR048322A1 (en) COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS
CR10145A (en) USEFUL TROPANAN DERIVATIVES IN THERAPY (DIVISIONAL EXP. 6800)
AR037329A1 (en) PIRAZOLO PIRIMIDINONA COMPOUNDS, PROCEDURES FOR THE PREPARATION OF THE SAME, PHARMACEUTICAL COMPOSITIONS OF THE SAME AND USES OF THE SAME IN THE PREPARATION OF MEDICINES
AR037676A1 (en) INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION WATERFALL; PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS AND PROCEDURE TO PREPARE FORMULA COMPOUNDS (I)
AR046394A1 (en) DERIVATIVES OF QUINOLINAS AND QUINAZOLINAS, METHOD OF PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
AR035617A1 (en) COMPOUNDS DERIVED FROM PHENETHANOLAMINE, COMBINATIONS AND PHARMACEUTICAL FORMULATIONS OF THE SAME, PROCESS FOR THEIR PREPARATION, ITS USE IN THE PREPARATION OF MEDICINES FOR THE TREATMENT OR PROPHYLAXIS OF A CLINICAL CONDITION FOR WHICH A BETAIEPAR BARDIAR AGENT IS ADDED
AR095192A1 (en) QUINOLINA AND QUINAZOLINAMIDAS AS MODULAR SODIUM CHANNELS
AR065499A1 (en) SERINO PROTEASAS INHIBITORS PHARMACEUTICAL COMPOSITIONS
ECSP088479A (en) DERIVATIVES OF OXADIAZOL
ATE380818T1 (en) PIPERAZINE-SUBSTITUTED ARYL-BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOSIS
AR055171A1 (en) CARBOXAMIDE DERIVATIVES AS ANTAGONISTS OF THE MUSCARINIC RECEIVER
CO5611152A2 (en) PIPERIDINE DERIVATIVE COMPOUNDS CHARACTERIZED FOR BEING ANTIGONISTS OF THE TACHYCINE RECEIVER, ESPECIALLY OF THE NK1 RECEIVER AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR041395A1 (en) PIRIDINE COMPOSITE PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE IT
CO5700776A2 (en) USEFUL COMPOUNDS FOR THE TREATMENT OF DISEASES
AR057464A1 (en) PROCEDURE FOR THE PREPARATION OF SULFONAMIDE DERIVATIVES
CO6241116A2 (en) PIRIMIDIL PIPERAZINAS USEFUL AS LEGANDS OF THE RECEIVER D3 / D2
CO4940505A1 (en) BENZOXAZINONE DOPAMINE D 4 RECEPTOR ANTAGONISTS
HRP20030610B1 (en) Process for the preparation of mesylates of piperazine derivatives
AR048267A1 (en) USEFUL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS

Legal Events

Date Code Title Description
FB Suspension of granting procedure