AR048322A1 - COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS - Google Patents

COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS

Info

Publication number
AR048322A1
AR048322A1 ARP050101096A ARP050101096A AR048322A1 AR 048322 A1 AR048322 A1 AR 048322A1 AR P050101096 A ARP050101096 A AR P050101096A AR P050101096 A ARP050101096 A AR P050101096A AR 048322 A1 AR048322 A1 AR 048322A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
group
different
same
Prior art date
Application number
ARP050101096A
Other languages
Spanish (es)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR048322A1 publication Critical patent/AR048322A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos para el tratamiento de afecciones inflamatorias, alérgicas y respiratorias. Reivindicacion 1: Un compuesto de formula (1) en la que el grupo (CH2)n-C(=O)Q1 está en la posicion meta o para, R1 y R2 se seleccionan independientemente entre H y alquilo C1-4, n es 0, 1 o 2 y Q1 es un grupo seleccionado entre los restos de formulas (2), *-NR8-Q2-A o *-NR8-Q3, en el que p es 1 o 2 y q es 1 o 2; Q2 es un enlace sencillo o un alquileno C1-4 opcionalmente sustituido con OH; R8 es H o alquilo C1-4 y, Q3 es alquilo C1-6 opcionalmente sustituido con NR9R10, OR9 o fenoxi, A se selecciona entre: cicloalquilo C3-10, estando dicho cicloalquilo opcionalmente enlazado con 1, 2, 3 o 4 átomos de C y estando opcionalmente sustituido con un grupo hidroxi, un grupo heterocíclico de 5 a 6 miembros, opcionalmente aromático, que contiene 1 o 2 heteroátomos seleccionados entre O, N o S, opcionalmente sustituido con uno o dos sustituyentes seleccionados entre alquilo C1-4, bencilo y ciclopropilmetilo o; un grupo de formulas (3), quinolilo o isoquinolilo; R3, R4, R5, R6 y R7 son iguales o diferentes y se seleccionan entre H, alquilo C1-4, OR9, SR9, SOR9, SO2R9, halo, CN, CF3, OCF3, SO2NR9R10, COOR9, CONR9R10, NR9R10, NHCOR10 y fenilo opcionalmente sustituido con OH; R9 y R10 son iguales o diferentes y se seleccionan entre H o alquilo C1-4; R11 se selecciona entre H u OH, y R12 y R13 son iguales o diferentes y se seleccionan entre H, alquilo C1-4 opcionalmente sustituido con OR9, C(=O)NH2, C(=O)CH3, N(CH3)C(=O)CH3, C(=O)OR9, fenilo opcionalmente sustituido con halogeno, piridilo opcionalmente sustituido con CN y oxadiazolilo opcionalmente sustituido con alquilo C1-4, y -* representa el punto de union al grupo carbonilo; o, si es apropiado, sus sales y/o isomeros, tautomeros, solvatos o variaciones isotopicas farmacéuticamente aceptables de los mismos.Compounds for the treatment of inflammatory, allergic and respiratory conditions. Claim 1: A compound of formula (1) wherein the group (CH2) nC (= O) Q1 is in the meta or para position, R1 and R2 are independently selected from H and C1-4 alkyl, n is 0, 1 or 2 and Q1 is a group selected from the residues of formulas (2), * -NR8-Q2-A or * -NR8-Q3, in which p is 1 or 2 and q is 1 or 2; Q2 is a single bond or a C1-4 alkylene optionally substituted with OH; R8 is H or C1-4 alkyl and, Q3 is C1-6 alkyl optionally substituted with NR9R10, OR9 or phenoxy, A is selected from: C3-10 cycloalkyl, said cycloalkyl being optionally linked with 1, 2, 3 or 4 atoms of C and being optionally substituted with a hydroxy group, a 5- to 6-membered heterocyclic group, optionally aromatic, containing 1 or 2 heteroatoms selected from O, N or S, optionally substituted with one or two substituents selected from C 1-4 alkyl, benzyl and cyclopropylmethyl or; a group of formulas (3), quinolyl or isoquinolyl; R3, R4, R5, R6 and R7 are the same or different and are selected from H, C1-4 alkyl, OR9, SR9, SOR9, SO2R9, halo, CN, CF3, OCF3, SO2NR9R10, COOR9, CONR9R10, NR9R10, NHCOR10 and phenyl optionally substituted with OH; R9 and R10 are the same or different and are selected from H or C1-4 alkyl; R11 is selected from H or OH, and R12 and R13 are the same or different and are selected from H, C1-4 alkyl optionally substituted with OR9, C (= O) NH2, C (= O) CH3, N (CH3) C (= O) CH3, C (= O) OR9, phenyl optionally substituted with halogen, pyridyl optionally substituted with CN and oxadiazolyl optionally substituted with C1-4 alkyl, and - * represents the point of attachment to the carbonyl group; or, if appropriate, its salts and / or isomers, tautomers, solvates or pharmaceutically acceptable isotopic variations thereof.

ARP050101096A 2004-03-23 2005-03-21 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS AR048322A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04290770 2004-03-23
US62502104P 2004-11-03 2004-11-03

Publications (1)

Publication Number Publication Date
AR048322A1 true AR048322A1 (en) 2006-04-19

Family

ID=34961254

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101096A AR048322A1 (en) 2004-03-23 2005-03-21 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY, ALLERGIC AND RESPIRATORY AFFECTIONS

Country Status (5)

Country Link
AR (1) AR048322A1 (en)
NL (1) NL1028599C2 (en)
PA (1) PA8627001A1 (en)
TW (1) TW200533351A (en)
WO (1) WO2005092860A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
CA2618089A1 (en) 2005-08-08 2007-02-15 Argenta Discovery Ltd. Bicyclo[2.2.]hept-7-ylamine derivatives and their uses
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2009087224A1 (en) 2008-01-11 2009-07-16 Novartis Ag Pyrimidines as kinase inhibitors
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
NZ594157A (en) 2008-12-30 2013-07-26 Pulmagen Therapeutics Inflammation Ltd Sulfonamide compounds for the treatment of respiratory disorders
WO2010150014A1 (en) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited 5r- 5 -deuterated glitazones for respiratory disease treatment
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
WO2011098746A1 (en) 2010-02-09 2011-08-18 Pulmagen Therapeutics (Inflammation) Limited Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
GB201002243D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
GB201002224D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
UY33597A (en) 2010-09-09 2012-04-30 Irm Llc COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
WO2012116217A1 (en) 2011-02-25 2012-08-30 Irm Llc Compounds and compositions as trk inhibitors
MA44037B1 (en) * 2016-06-06 2020-03-31 Arena Pharm Inc Beta 3 adrenergic receptor modulators useful in the treatment or prevention of disorders associated therewith

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700681A (en) * 1971-02-16 1972-10-24 Pfizer 2-hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-aminoethyl)pyridines
EP0220054A3 (en) * 1985-10-16 1987-12-02 Glaxo Group Limited Ethanolamine derivatives
ATE247641T1 (en) * 1996-11-14 2003-09-15 Pfizer PYRIDINE INTERMEDIATE PRODUCTS USABLE FOR PRODUCING BETA-ADRENERGIC RECEPTOR AGONISTS
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
EP1477167A1 (en) * 2003-05-15 2004-11-17 Pfizer Limited [(2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propyl] phenyl derivatives as beta2 agonists

Also Published As

Publication number Publication date
TW200533351A (en) 2005-10-16
NL1028599A1 (en) 2005-09-26
NL1028599C2 (en) 2006-01-03
PA8627001A1 (en) 2006-05-16
WO2005092860A1 (en) 2005-10-06

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