PE20120508A1 - INHIBITORS OF THE REPLICATION OF FLU VIRUSES - Google Patents
INHIBITORS OF THE REPLICATION OF FLU VIRUSESInfo
- Publication number
- PE20120508A1 PE20120508A1 PE2011002120A PE2011002120A PE20120508A1 PE 20120508 A1 PE20120508 A1 PE 20120508A1 PE 2011002120 A PE2011002120 A PE 2011002120A PE 2011002120 A PE2011002120 A PE 2011002120A PE 20120508 A1 PE20120508 A1 PE 20120508A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- aromatic
- optionally replaced
- ilamino
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
REFERIDA A UN DERIVADO DE PIRROLOPIRIDINA DE FORMULA (IA), DONDE Z1 ES F, Cl, CN, NO2, ENTRE OTROS; Z2 ES R*, OR*, CO2R*, ENTRE OTROS; Z3 ES H, OH, NH2, HALOGENO, ENTRE OTROS; R1 ES H O ALQUILO C1-C6; R2 ES H, F, NH2, NH(ALQUILO C1-C4), ENTRE OTROS; R3 ES H, Cl, F, OH, O(ALQUILO C1-C4), ENTRE OTROS; R4 ES (a), (b) O (c); T ES UN CARBOCICLO NO AROMATICO C3-C10 OPCIONALMENTE SUSTITUIDO CON JA O UN HETEROCICLO NO AROMATICO DE 3 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON JB; J ES UN HETEROCICLO NO AROMATICO DE 3 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON JB; D ES UN HETEROCICLO NO AROMATICO DE 4 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON JD1; JA Y JB SON HALOGENO, CN, NCO, ENTRE OTROS; R9 ES H, HALOGENO, CN, OH, AMINO, ALQUILO C1-C6, ENTRE OTROS; R* ES H, ALQUILO C1-C6, CARBOCICLO C3-C8 NO AROMATICO, ENTRE OTROS; JD1 ES HALOGENO, CN, OXO, ENTRE OTROS; R13 Y R14 SON H, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; j Y z SON 1 O 2; t ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: ACIDO (R)-3-(3-((2-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDIN-3-IL)-5-FLUOROPIRIMIDIN-4-ILAMINO)METIL)PIPERIDINA-1-CARBONIL)PIRAZINA-2-CARBOXILICO, (S)-1-(3-((2-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDIN-3-IL)-5-FLUOROPIRIMIDIN-4-ILAMINO)METIL)PIPERIDIN-1-IL)-2-METOXIETANONA, (S)-1-(3-((2-(5-CLORO-1H-PIRROLO[2,3-b]PIRIDIN-3-IL)-5-FLUOROPIRIMIDIN-4-ILAMINO)METIL)PIPERIDIN-1-IL)PROPAN-1-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA REPLICACION DEL VIRUS DE LA INFLUENZAREFERRING TO A PYRROLOPYRIDINE DERIVATIVE OF FORMULA (IA), WHERE Z1 IS F, Cl, CN, NO2, AMONG OTHERS; Z2 IS R *, OR *, CO2R *, AMONG OTHERS; Z3 IS H, OH, NH2, HALOGEN, AMONG OTHERS; R1 IS H O C1-C6 ALKYL; R2 IS H, F, NH2, NH (C1-C4 ALKYL), AMONG OTHERS; R3 IS H, Cl, F, OH, O (C1-C4 ALKYL), AMONG OTHERS; R4 IS (a), (b) O (c); T IS A NON-AROMATIC C3-C10 CARBOCICLE OPTIONALLY REPLACED WITH JA OR A NON-AROMATIC HETEROCYCLE OF 3 TO 10 MEMBERS OPTIONALLY REPLACED WITH JB; J IS A NON-AROMATIC HETEROCICLE OF 3 TO 10 MEMBERS OPTIONALLY REPLACED WITH JB; D IS A NON-AROMATIC HETEROCYCLE OF 4 TO 10 MEMBERS OPTIONALLY REPLACED WITH JD1; JA AND JB ARE HALOGENO, CN, NCO, AMONG OTHERS; R9 IS H, HALOGEN, CN, OH, AMINO, C1-C6 ALKYL, AMONG OTHERS; R * IS H, C1-C6 ALKYL, NON-AROMATIC C3-C8 CARBOCYCLE, AMONG OTHERS; JD1 IS HALOGEN, CN, OXO, AMONG OTHERS; R13 AND R14 ARE H, HALOGEN, C1-C6 ALKYL, AMONG OTHERS; j AND z ARE 1 O 2; t IS 0, 1 OR 2. THE PREFERRED COMPOUNDS ARE: ACID (R) -3- (3 - ((2- (5-CHLORO-1H-PIRROLO [2,3-b] PYRIDIN-3-IL) -5- FLUOROPYRIMIDIN-4-ILAMINO) METHYL) PIPERIDINE-1-CARBONYL) PYRAZINE-2-CARBOXYL, (S) -1- (3 - ((2- (5-CHLORO-1H-PIRROLO [2,3-b] PYRIDIN- 3-IL) -5-FLUOROPYRIMIDIN-4-ILAMINO) METHYL) PIPERIDIN-1-IL) -2-METOXYETHANONE, (S) -1- (3 - ((2- (5-CHLORO-1H-PYRROLO [2, 3-b] PYRIDIN-3-IL) -5-FLUOROPYRIMIDIN-4-ILAMINO) METHYL) PIPERIDIN-1-IL) PROPAN-1-ONA, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS INHIBIT THE REPLICATION OF THE INFLUENZA VIRUS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18771309P | 2009-06-17 | 2009-06-17 | |
US28778109P | 2009-12-18 | 2009-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120508A1 true PE20120508A1 (en) | 2012-05-09 |
Family
ID=42537408
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011002120A PE20120508A1 (en) | 2009-06-17 | 2010-06-17 | INHIBITORS OF THE REPLICATION OF FLU VIRUSES |
PE2015002683A PE20160127A1 (en) | 2009-06-17 | 2010-06-17 | ACID COMPOUND (2S, 3S) -3 - ((2- (5-FLUORO-1H-PIRROLO [2,3-B] PYRIDIN-3-IL) -5-FLUOROPYRIMIDIN-4-IL) AMINO) BICICLO [2.2. 2] OCTANE-2-CARBOXYL AS AN INHIBITOR OF THE REPLICATION OF THE FLU VIRUS TO H1N1, H2N2, H3N2 or H5N1 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015002683A PE20160127A1 (en) | 2009-06-17 | 2010-06-17 | ACID COMPOUND (2S, 3S) -3 - ((2- (5-FLUORO-1H-PIRROLO [2,3-B] PYRIDIN-3-IL) -5-FLUOROPYRIMIDIN-4-IL) AMINO) BICICLO [2.2. 2] OCTANE-2-CARBOXYL AS AN INHIBITOR OF THE REPLICATION OF THE FLU VIRUS TO H1N1, H2N2, H3N2 or H5N1 |
Country Status (38)
Country | Link |
---|---|
US (7) | US20120171245A1 (en) |
EP (3) | EP3141252B8 (en) |
JP (6) | JP5721706B2 (en) |
KR (3) | KR101702609B1 (en) |
CN (5) | CN104940202B (en) |
AP (1) | AP3631A (en) |
AR (1) | AR077130A1 (en) |
AU (1) | AU2010262905B2 (en) |
BR (1) | BRPI1011993A2 (en) |
CA (1) | CA2764177C (en) |
CL (1) | CL2011003192A1 (en) |
CO (1) | CO6491048A2 (en) |
CY (2) | CY1118246T1 (en) |
DK (2) | DK3141252T3 (en) |
EA (3) | EA025276B1 (en) |
EC (1) | ECSP12011610A (en) |
ES (2) | ES2692396T3 (en) |
GE (3) | GEP20207129B (en) |
HK (4) | HK1204322A1 (en) |
HR (2) | HRP20161577T1 (en) |
HU (1) | HUE031048T2 (en) |
IL (2) | IL216980B (en) |
LT (2) | LT3141252T (en) |
ME (1) | ME02558B (en) |
MX (2) | MX2011013475A (en) |
NZ (2) | NZ597059A (en) |
PE (2) | PE20120508A1 (en) |
PH (1) | PH12015501678A1 (en) |
PL (2) | PL3141252T3 (en) |
PT (2) | PT3141252T (en) |
RS (2) | RS57869B1 (en) |
SG (3) | SG176722A1 (en) |
SI (2) | SI2442809T1 (en) |
TR (1) | TR201815272T4 (en) |
TW (4) | TWI666209B (en) |
UY (1) | UY32717A (en) |
WO (1) | WO2010148197A1 (en) |
ZA (2) | ZA201109127B (en) |
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