PE20050756A1 - Heterociclicos azabiciclicos como moduladores del receptor cannabinoide - Google Patents
Heterociclicos azabiciclicos como moduladores del receptor cannabinoideInfo
- Publication number
- PE20050756A1 PE20050756A1 PE2005000014A PE2005000014A PE20050756A1 PE 20050756 A1 PE20050756 A1 PE 20050756A1 PE 2005000014 A PE2005000014 A PE 2005000014A PE 2005000014 A PE2005000014 A PE 2005000014A PE 20050756 A1 PE20050756 A1 PE 20050756A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- azabicycle
- alkinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
Abstract
SE REFIERE A HETEROCICLICOS AZABICICLICOS DE FORMULA I DONDE n ES UN ENLACE SENCILLO, ENLACE DOBLE; R1 ES HALO, CIANO, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, CICLOALQUILALQUILO, HETEROCICLILO, HETEROCICLILOALQUILO, ARILO, NR8R9, ENTRE OTROS; R2 ES HALOGENO, CIANO, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R3 ES ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS; R6 ES H, ALQUILO, CICLOALQUILO, HETEROCICLILO, CICLOALQUILALQUILO, ARILO, HETEROARILO, ENTRE OTROS; R7 ESTA AUSENTE CUANDO n ES UN ENLACE DOBLE; R7 ES H, ALQUILO, CICLOALQUILO, HETEROCICLILO, CICLOALQUILALQUILO, HETEROCICLOALQUILO, ARILO, ENTRE OTROS; R8 Y R9 SON H, ALQUILO, ARILO, ARILAQUILO, CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 7,8-BIS(4-CLOROFENIL)-[1,2,4]TRIAZOLO[4,3-b]PIRIDAZIN-3(2H)-ONA, 2-(4-CLOROBENCIL)-7,8-BIS(4-CLOROFENIL)-(1,2,4]TRIAZOLO[4,3-b]PIRIDAZIN-3(2H)-ONA, 7,8-BIS(4-CLOROFENIL)-2-((5-(TRIFLUOROMETIL)PIRIDIN-2-IL)METIL)-[1,2,4]TRIAZOLO[4,3-b]PIRIDAZIN-3(2H)-ONA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON MODULADORES DEL RECEPTOR CANNABINOIDE UTILES EN LA REGULACION DEL APETITO, INMUNODEPRESION, ANALGESIA, INFLAMACION
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53145103P | 2003-12-19 | 2003-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050756A1 true PE20050756A1 (es) | 2005-10-06 |
Family
ID=34710226
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000014A PE20050756A1 (es) | 2003-12-19 | 2005-01-03 | Heterociclicos azabiciclicos como moduladores del receptor cannabinoide |
PE2005000013A PE20051047A1 (es) | 2003-12-19 | 2005-01-03 | COMPUESTOS [1,2,4] TRIAZOL [4,3-b]PIRIDAZIN-3-ONA COMO MODULADORES DE RECEPTOR CANABINOIDE |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000013A PE20051047A1 (es) | 2003-12-19 | 2005-01-03 | COMPUESTOS [1,2,4] TRIAZOL [4,3-b]PIRIDAZIN-3-ONA COMO MODULADORES DE RECEPTOR CANABINOIDE |
Country Status (11)
Country | Link |
---|---|
US (1) | US7037910B2 (es) |
EP (1) | EP1699796A4 (es) |
JP (1) | JP2007514756A (es) |
CN (2) | CN1918164A (es) |
AR (2) | AR047063A1 (es) |
IS (1) | IS8501A (es) |
NO (1) | NO20062689L (es) |
PE (2) | PE20050756A1 (es) |
TW (2) | TW200528455A (es) |
WO (1) | WO2005061509A1 (es) |
ZA (2) | ZA200604645B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
US20030176437A1 (en) | 2001-08-31 | 2003-09-18 | D.M. Watterson | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death |
EP1697371B1 (en) | 2003-12-19 | 2007-04-25 | Bristol-Myers Squibb Company | Azabicyclic heterocycles as cannabinoid receptor modulators |
US20060025448A1 (en) * | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
WO2006050359A2 (en) * | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
ES2441718T3 (es) | 2004-11-02 | 2014-02-06 | Northwestern University | Compuestos de piridazina, composiciones y métodos |
US7317012B2 (en) * | 2005-06-17 | 2008-01-08 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoind-1 receptor modulators |
MX2008012400A (es) | 2006-03-30 | 2008-10-10 | Irm Llc | Azolopirimidinas como inhibidores de actividad de cannabinoide 1. |
EP2015750A2 (en) * | 2006-04-28 | 2009-01-21 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
CN101754762A (zh) | 2006-04-28 | 2010-06-23 | 西北大学 | 用于治疗神经炎症性疾病的包含哒嗪化合物的制剂 |
EP2023909B1 (en) * | 2006-05-04 | 2009-11-18 | Solvay Pharmaceuticals B.V. | Muscarinic agonists to treat impulse control disorders |
BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
US20160331729A9 (en) * | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
JP5548120B2 (ja) * | 2007-04-11 | 2014-07-16 | オメロス コーポレーション | 嗜癖の予防および治療のための組成物および方法 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US8642766B2 (en) * | 2008-05-05 | 2014-02-04 | Ryan A. Shenvi | Synthesis of (+) cortistatin A and related compounds |
UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
US8785608B2 (en) | 2009-08-26 | 2014-07-22 | Sanofi | Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
FR2958850B1 (fr) * | 2010-04-14 | 2012-07-06 | Centre Nat Rech Scient | Medicaments pour la prevention ou le traitement des addictions aux drogues |
PL2560949T3 (pl) * | 2010-04-20 | 2017-01-31 | Università Degli Studi Di Roma "La Sapienza" | Pochodne tranylocyprominy jako inhibitory demetylazy histonowej LSD1 i/lub LSD2 |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
JP5437525B1 (ja) | 2012-12-28 | 2014-03-12 | 株式会社ナード研究所 | チロシン誘導体およびチロシン誘導体の製造方法 |
CN103933569B (zh) * | 2013-01-22 | 2017-01-11 | 复旦大学 | 一种抗肺癌药物组合物及其应用、药盒和包装件 |
DK3099684T3 (en) * | 2014-01-29 | 2018-07-16 | Ucb Biopharma Sprl | HETEROARYLAMIDS AS INHIBITORS OF PROTEIN AGGREGATION |
CA3026083C (en) | 2016-06-03 | 2024-04-02 | The Trustees Of Columbia University In The City Of New York | Methods of treating prader-willi syndrome |
CN108178759B (zh) * | 2018-01-05 | 2020-06-09 | 上海瑞纷医药科技有限责任公司 | 一种α-肾上腺素受体拮抗剂的合成方法 |
CN108498511A (zh) * | 2018-04-21 | 2018-09-07 | 徐晶 | 一种治疗膝关节骨性关节炎的药物组合物及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1164198B (it) * | 1983-04-28 | 1987-04-08 | Isf Spa | Preparazione di un derivato piridazinico farmacologicamente attivo |
CA2346659A1 (en) * | 1998-10-06 | 2000-04-13 | Michiyo Gyoten | Condensed pyridazine compounds, their production and use |
JP2002205992A (ja) | 2000-11-08 | 2002-07-23 | Takeda Chem Ind Ltd | 二環式トリアゾロン誘導体およびそれを含有する除草剤 |
GB0107751D0 (en) * | 2001-03-28 | 2001-05-16 | Pfizer Ltd | Pharmaceutically active compounds |
AU2003205926A1 (en) * | 2002-02-07 | 2003-09-02 | Pfizer Limited | Use of pde5 inhibitors such as sildenafil in the treatment of polycystic ovary syndrome |
CA2478389A1 (en) * | 2002-03-25 | 2003-10-09 | Merck & Co., Inc. | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
EP1594848A1 (en) | 2003-02-19 | 2005-11-16 | Neurogen Corporation | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds |
-
2004
- 2004-12-15 TW TW093138982A patent/TW200528455A/zh unknown
- 2004-12-15 TW TW093138971A patent/TW200530246A/zh unknown
- 2004-12-17 AR ARP040104772A patent/AR047063A1/es not_active Application Discontinuation
- 2004-12-17 CN CNA2004800419043A patent/CN1918164A/zh active Pending
- 2004-12-17 CN CNA2004800419202A patent/CN1918165A/zh active Pending
- 2004-12-17 US US11/015,876 patent/US7037910B2/en active Active
- 2004-12-17 AR ARP040104771A patent/AR046964A1/es not_active Application Discontinuation
- 2004-12-20 EP EP04814691A patent/EP1699796A4/en not_active Withdrawn
- 2004-12-20 WO PCT/US2004/042542 patent/WO2005061509A1/en active Application Filing
- 2004-12-20 JP JP2006545502A patent/JP2007514756A/ja active Pending
-
2005
- 2005-01-03 PE PE2005000014A patent/PE20050756A1/es not_active Application Discontinuation
- 2005-01-03 PE PE2005000013A patent/PE20051047A1/es not_active Application Discontinuation
-
2006
- 2006-06-06 ZA ZA200604645A patent/ZA200604645B/xx unknown
- 2006-06-08 IS IS8501A patent/IS8501A/xx unknown
- 2006-06-09 ZA ZA200604778A patent/ZA200604778B/xx unknown
- 2006-06-12 NO NO20062689A patent/NO20062689L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR047063A1 (es) | 2006-01-04 |
IS8501A (is) | 2006-06-08 |
US20050192278A1 (en) | 2005-09-01 |
WO2005061509A1 (en) | 2005-07-07 |
NO20062689L (no) | 2006-09-12 |
PE20051047A1 (es) | 2005-12-16 |
EP1699796A1 (en) | 2006-09-13 |
TW200530246A (en) | 2005-09-16 |
CN1918165A (zh) | 2007-02-21 |
EP1699796A4 (en) | 2009-03-04 |
JP2007514756A (ja) | 2007-06-07 |
ZA200604645B (en) | 2007-11-28 |
AR046964A1 (es) | 2006-01-04 |
ZA200604778B (en) | 2007-12-27 |
US7037910B2 (en) | 2006-05-02 |
TW200528455A (en) | 2005-09-01 |
CN1918164A (zh) | 2007-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20050756A1 (es) | Heterociclicos azabiciclicos como moduladores del receptor cannabinoide | |
PE20060555A1 (es) | Derivados de pirrol-oxindol como moduladores del receptor de progesterona | |
AR049696A1 (es) | Derivados de indol | |
PE20060653A1 (es) | Derivados triciclicos condensados como moduladores del receptor 5-ht1 | |
PE20071064A1 (es) | Derivados de pirrolonaftiridinonas como antibacterianos | |
PE20050419A1 (es) | Compuestos de pirazol e imidazol biciclicos como ligandos de receptores cannabinoides | |
PE20040600A1 (es) | Derivados de triazol como antagonistas del receptor de taquicinina | |
PE20040590A1 (es) | Composiciones de pirrolotriazina anilina como inhibidores de cinasa | |
PE20040168A1 (es) | Compuestos de pirrolopiridazina como inhibidores de las proteina cinasas | |
PE20090441A1 (es) | DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-ILMETIL PIPERIDINA SUSTITUIDA | |
PE20010681A1 (es) | Derivados de benzodiazepina como antagonistas del receptor de glutamato metabotropico | |
PE20090279A1 (es) | Derivados de 3,3-espiroindolinona como agentes antagonistas de mdm2 | |
PE20010574A1 (es) | Derivados de indol como ligandos del receptor 5-ht2 | |
PE20030471A1 (es) | Compuesto de imidazopiridin como moduladores del receptor 5-ht4 | |
CY1109263T1 (el) | Ανταγωνιστες των α2α υποδοχεων αδενοσινης 2-alkynyl-kai 2-αλκενυλ-pyrazolo-[4,3-ε]-1,2,4-triazolo-[1,5-c]-pyrimidine | |
PE20030062A1 (es) | Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas | |
PE20080403A1 (es) | Derivados heterociclicos fusionados y metodos de uso | |
PE20060531A1 (es) | Derivados de piridazin-3-(2h)-ona como inhibidores de la fosfodiesterasa 4 | |
PE20030431A1 (es) | DERIVADOS QUINUCLIDINAS COMO AGONISTAS DEL RECEPTOR NICOTINICO DE LA ACETILCOLINA TIPO a7 | |
PE20010629A1 (es) | Derivados de triazolpiridinamina como ligandos de receptores de adenosina | |
AR061651A1 (es) | Analogos de piridina ii | |
PE20030808A1 (es) | Derivados triciclicos heterociclicos como antagonistas receptores de trombina | |
PE20051173A1 (es) | Compuestos azabiciclico (3.1.0) hexanos como moduladores de receptores de dopamina d3 | |
PE20060010A1 (es) | 2,3,4,5-TETRAHIDRO-1H-BENZO[d]AZEPINAS 6-SUSTITUIDAS COMO AGONISTAS DEL RECEPTOR 5-HT2C | |
PE20080557A1 (es) | Compuestos de azabencimidazolilo con actividad sobre los receptores glutamato |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |