PE20050492A1 - Compuestos de sulfoniltetrahidro-3h-benzo(e) indol-8-amina como ligandos de la 5-hidroxitriptamina-6 - Google Patents
Compuestos de sulfoniltetrahidro-3h-benzo(e) indol-8-amina como ligandos de la 5-hidroxitriptamina-6Info
- Publication number
- PE20050492A1 PE20050492A1 PE2004001096A PE2004001096A PE20050492A1 PE 20050492 A1 PE20050492 A1 PE 20050492A1 PE 2004001096 A PE2004001096 A PE 2004001096A PE 2004001096 A PE2004001096 A PE 2004001096A PE 20050492 A1 PE20050492 A1 PE 20050492A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- benzo
- sulfonyltetrahydro
- hydroxitriptamine
- binders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I DONDE X ES O, S, ENTRE OTROS; n ES 1-2; R1 ES H, CN, CHO, ENTRE OTROS; R2 ES ALQUILO C1-C6, CICLOALQUILO C3-C7, ARILO, ENTRE OTROS; R3 ES HALOGENO, CN, ALQUILO C1-C6, ENTRE OTROS; R4 Y R5 SON CADA UNO H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS. TAMBIEN REFERIDA A UNA COMPOSICION N,N-DIMETIL-3-(FENILSULFONIL)-6,7,8,9-TETRAHIDRO-3H-BENZO[e]INDOL-8-AMINA, 3-[(2,6-DICLOROIMIDAZOL[2,1-b][1,3]TIAZO-5-LIL)SULFONIL]-N,N-DIMETIL-6,7,8,9-TETRAHIDRO-3H-BENZO[e]INDOL-8-AMINA, ENTRE OTROS. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DEL DESORDEN CNS RELACIONADO CON O AFECTADO POR EL RECEPTOR 5-HT6
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51906303P | 2003-11-10 | 2003-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050492A1 true PE20050492A1 (es) | 2005-10-21 |
Family
ID=34590346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004001096A PE20050492A1 (es) | 2003-11-10 | 2004-11-09 | Compuestos de sulfoniltetrahidro-3h-benzo(e) indol-8-amina como ligandos de la 5-hidroxitriptamina-6 |
Country Status (13)
Country | Link |
---|---|
US (2) | US7288561B2 (es) |
EP (1) | EP1682502A1 (es) |
JP (1) | JP2007510730A (es) |
CN (1) | CN1878756A (es) |
AR (1) | AR046446A1 (es) |
AU (1) | AU2004289656A1 (es) |
BR (1) | BRPI0416371A (es) |
CA (1) | CA2543627A1 (es) |
GT (1) | GT200400231A (es) |
MX (1) | MXPA06005103A (es) |
PE (1) | PE20050492A1 (es) |
TW (1) | TW200524864A (es) |
WO (1) | WO2005047252A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR046194A1 (es) | 2003-11-04 | 2005-11-30 | Mayo Foundation | Metodo de tratamiento del linfoma de celulas del manto |
TW200524864A (en) * | 2003-11-10 | 2005-08-01 | Wyeth Corp | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands |
EP1695973A1 (en) * | 2005-02-24 | 2006-08-30 | Neuro3D | Ocaperidone salt and pharmaceutical compositions containing the same |
EP1747779A1 (en) * | 2005-07-28 | 2007-01-31 | Laboratorios Del Dr. Esteve, S.A. | Tetrahydro-b-carbolin-sulfonamide derivatives as 5-HT6 ligands |
WO2007053353A2 (en) * | 2005-10-28 | 2007-05-10 | Wyeth | Pyrrolo[2,3-f] and [3,2-f]isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands |
WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
US20100120747A1 (en) * | 2006-06-23 | 2010-05-13 | Laboratorios Del Dr. Esteve, S.A. | Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity |
JP2010508344A (ja) | 2006-10-30 | 2010-03-18 | ビオヴィトルム・アクチボラゲット(プブリクト) | 8−スルホニル−1,3,4,8−テトラヒドロ−2h−[1,4]オキサゼピノ[6,7−e]インドール誘導体、および5−ht6受容体リガンドとしてのその使用 |
EP2053052A1 (en) * | 2007-10-23 | 2009-04-29 | Laboratorios del Dr. Esteve S.A. | Process for the preparation of 6-substituted imidazo[2,1-b]thiazole-5-sulfonyl halide |
ES2568262T3 (es) * | 2009-04-23 | 2016-04-28 | Abbvie Inc. | Moduladores de receptores de 5-HT y sus métodos de uso |
US8518933B2 (en) * | 2009-04-23 | 2013-08-27 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
AR079234A1 (es) * | 2009-12-01 | 2012-01-04 | Abbott Lab | Derivados heterociclicos condensados nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos para tratar afecciones oncologicas, del sistema nervioso y/o del sistema inmune. |
CA2953004C (en) | 2014-07-08 | 2023-02-21 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4454150A (en) * | 1981-10-19 | 1984-06-12 | Ayerst, Mckenna & Harrison Inc. | 6,7,8,9-Tetrahydro-3H-benz(e)indol-7-amines and a method of dopamine receptor stimulation therewith |
US4370341A (en) * | 1980-12-11 | 1983-01-25 | Ayerst, Mckenna & Harrison, Ltd. | 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives |
US4929622A (en) * | 1987-09-24 | 1990-05-29 | Hoechst-Roussel Pharmaceuticals, Inc. | 2,6-Methanopyrrolo-3-benzazocines |
ES2130135T3 (es) * | 1990-01-11 | 1999-07-01 | Upjohn Co | Nuevos compuestos heterociclicos de 6,7,8,9-tetrahidro-3h-benz(e)indol con actividad terapeutica sobre el sistema nervioso central. |
CA2075057A1 (en) * | 1990-03-15 | 1991-09-16 | Pharmacia & Upjohn Company Llc | Therapeutically useful heterocyclic indole compounds |
TW200524864A (en) * | 2003-11-10 | 2005-08-01 | Wyeth Corp | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands |
-
2004
- 2004-11-02 TW TW093133285A patent/TW200524864A/zh unknown
- 2004-11-04 CA CA002543627A patent/CA2543627A1/en not_active Abandoned
- 2004-11-04 EP EP04800681A patent/EP1682502A1/en not_active Withdrawn
- 2004-11-04 CN CNA2004800329371A patent/CN1878756A/zh active Pending
- 2004-11-04 AU AU2004289656A patent/AU2004289656A1/en not_active Abandoned
- 2004-11-04 WO PCT/US2004/036622 patent/WO2005047252A1/en active Application Filing
- 2004-11-04 MX MXPA06005103A patent/MXPA06005103A/es not_active Application Discontinuation
- 2004-11-04 JP JP2006539629A patent/JP2007510730A/ja active Pending
- 2004-11-04 BR BRPI0416371-0A patent/BRPI0416371A/pt not_active Application Discontinuation
- 2004-11-09 US US10/984,633 patent/US7288561B2/en not_active Expired - Fee Related
- 2004-11-09 PE PE2004001096A patent/PE20050492A1/es not_active Application Discontinuation
- 2004-11-09 AR ARP040104127A patent/AR046446A1/es unknown
- 2004-11-09 GT GT200400231A patent/GT200400231A/es unknown
-
2007
- 2007-09-06 US US11/899,631 patent/US7671079B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GT200400231A (es) | 2005-06-09 |
US7288561B2 (en) | 2007-10-30 |
AU2004289656A1 (en) | 2005-05-26 |
MXPA06005103A (es) | 2006-07-10 |
AR046446A1 (es) | 2005-12-07 |
US20050101596A1 (en) | 2005-05-12 |
US7671079B2 (en) | 2010-03-02 |
WO2005047252A1 (en) | 2005-05-26 |
BRPI0416371A (pt) | 2007-03-13 |
TW200524864A (en) | 2005-08-01 |
CA2543627A1 (en) | 2005-05-26 |
US20080085925A1 (en) | 2008-04-10 |
CN1878756A (zh) | 2006-12-13 |
JP2007510730A (ja) | 2007-04-26 |
EP1682502A1 (en) | 2006-07-26 |
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