PE20050282A1 - DERIVADOS DE 2-[AMINO-(OCTIL O NONIL)-PIRROLIDIN-3-IL]-2,2-DIFENILACETAMIDA COMO ANTAGONISTAS MUSCARINICOS SELECTIVOS SUBTIPOS hM2 y hM3, COMPOSICION FARMACEUTICA QUE LOS CONTIENE, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIOS - Google Patents
DERIVADOS DE 2-[AMINO-(OCTIL O NONIL)-PIRROLIDIN-3-IL]-2,2-DIFENILACETAMIDA COMO ANTAGONISTAS MUSCARINICOS SELECTIVOS SUBTIPOS hM2 y hM3, COMPOSICION FARMACEUTICA QUE LOS CONTIENE, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIOSInfo
- Publication number
- PE20050282A1 PE20050282A1 PE2004000578A PE2004000578A PE20050282A1 PE 20050282 A1 PE20050282 A1 PE 20050282A1 PE 2004000578 A PE2004000578 A PE 2004000578A PE 2004000578 A PE2004000578 A PE 2004000578A PE 20050282 A1 PE20050282 A1 PE 20050282A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- diphenylacetamide
- pyrrolidin
- alkyl
- muscarinal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRROLIDINA DE FORMULA I DONDE R1 Y R2 SON ALQUILO C1-C4, ALQUENILO C2-C4, ALQUINILO C2-C4, CICLOALQUILO C3-C6, ENTRE OTROS; O DOS GRUPOS R1 ADYACENTES O DOS GRUPOS R2 ADYACENTES SE UNEN PARA FORMAR C3-C6 ALQUILENO, (ALQUILEN C2-C4)O, O(ALQUILEN C1-C4)O; R3 ES ALQUILO C1-C4 o F; R4 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; O AMBOS GRUPOS R4 SE UNEN JUNTO AL N AL QUE ESTAN UNIDOS PARA FORMAR HETEROCICLILO C3-C6; R5 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, CICLOALQUILO C3-C6, ENTRE OTROS; a ES UN ENTERO ENTRE 0 Y 3; b ES UN ENTERO ENTRE 0 Y 3; c ES N ENTERO ENTRE 0 Y 4; d ES 1 o 2; e ES 8 o 9. SON COMPUESTOS PREFERIDOS: 2-[(S)-1-(8-METILAMINOOCTIL)PIRROLIDIN-3-IL]-2,2-DIFENILACETAMIDA; 2-[(S)-1-(8-ISOPROPILAMINOOCTIL)PIRROLIDIN-3-IL]-2,2-DIFENILACETAMIDA; 2-[(S)-1-(8-PROP-1-ILAMINOOCTIL)PIRROLIDIN-3-IL]-2,2-DIFENILACETAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO PARA PREPARAR ESTOS COMPUESTOS Y A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR MUSCARINICO Y SON UTILES PARA TRATAR TRASTORNOS RELACIONADOS CON ESTE RECEPTOR
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47845603P | 2003-06-13 | 2003-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050282A1 true PE20050282A1 (es) | 2005-04-29 |
Family
ID=33563773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004000578A PE20050282A1 (es) | 2003-06-13 | 2004-06-10 | DERIVADOS DE 2-[AMINO-(OCTIL O NONIL)-PIRROLIDIN-3-IL]-2,2-DIFENILACETAMIDA COMO ANTAGONISTAS MUSCARINICOS SELECTIVOS SUBTIPOS hM2 y hM3, COMPOSICION FARMACEUTICA QUE LOS CONTIENE, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIOS |
Country Status (22)
Country | Link |
---|---|
US (5) | US7183292B2 (es) |
EP (1) | EP1633707A1 (es) |
JP (1) | JP2007507496A (es) |
KR (1) | KR20060017541A (es) |
CN (2) | CN100406435C (es) |
AR (1) | AR044676A1 (es) |
AU (1) | AU2004253869B2 (es) |
BR (1) | BRPI0411358A (es) |
CA (1) | CA2525801A1 (es) |
CL (1) | CL2004001431A1 (es) |
CO (1) | CO5650231A2 (es) |
IS (1) | IS8155A (es) |
MA (1) | MA27852A1 (es) |
MX (1) | MXPA05013256A (es) |
MY (1) | MY139290A (es) |
NO (1) | NO20060191L (es) |
NZ (1) | NZ543805A (es) |
PE (1) | PE20050282A1 (es) |
RU (1) | RU2337095C2 (es) |
TW (1) | TW200510298A (es) |
WO (1) | WO2005003090A1 (es) |
ZA (1) | ZA200509942B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
EP1644356A1 (en) * | 2003-07-11 | 2006-04-12 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
JP2007528418A (ja) * | 2004-03-11 | 2007-10-11 | セラヴァンス, インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
JP2007528414A (ja) * | 2004-03-11 | 2007-10-11 | セラヴァンス, インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
TW200540154A (en) * | 2004-06-10 | 2005-12-16 | Theravance Inc | Crystalline form of a substituted pyrrolidine compound |
GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
WO2008103426A1 (en) * | 2007-02-23 | 2008-08-28 | Theravance, Inc. | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
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US3192206A (en) * | 1961-12-04 | 1965-06-29 | Robins Co Inc A H | 4-(omega-aminoalkyl)-3, 3-disubstitutedn-hydrocarbon-2-pyrrolidinones and corresponding-2-thionpyrrolidinones |
US3192210A (en) * | 1961-12-04 | 1965-06-29 | Robins Co Inc A H | 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones |
US3247222A (en) * | 1962-12-26 | 1966-04-19 | Robins Co Inc A H | Alpha (nu-hydrocarbonpyrrolidyl-3-) alpha, alpha carbocyclic arylacetamides |
US3732247A (en) * | 1970-08-14 | 1973-05-08 | Robins Co Inc A H | 3-di-substituted methylene pyrrolidines wherein the 1-or n-lower-alkyl substituent contains at least two carbon atoms |
US4002766A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | Antiarrhythmia methods |
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TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
US7317102B2 (en) | 2003-04-01 | 2008-01-08 | Theravance, Inc. | Diarylmethyl and related compounds |
TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
EP1644356A1 (en) | 2003-07-11 | 2006-04-12 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
PE20050973A1 (es) * | 2003-10-29 | 2005-11-19 | Theravance Inc | Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos |
JP2007528418A (ja) | 2004-03-11 | 2007-10-11 | セラヴァンス, インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
JP2007528414A (ja) | 2004-03-11 | 2007-10-11 | セラヴァンス, インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
TW200540154A (en) * | 2004-06-10 | 2005-12-16 | Theravance Inc | Crystalline form of a substituted pyrrolidine compound |
-
2004
- 2004-06-03 TW TW093115971A patent/TW200510298A/zh unknown
- 2004-06-09 CL CL200401431A patent/CL2004001431A1/es unknown
- 2004-06-10 EP EP04776527A patent/EP1633707A1/en not_active Withdrawn
- 2004-06-10 CA CA002525801A patent/CA2525801A1/en not_active Abandoned
- 2004-06-10 US US10/865,527 patent/US7183292B2/en active Active
- 2004-06-10 RU RU2006101151/04A patent/RU2337095C2/ru not_active IP Right Cessation
- 2004-06-10 WO PCT/US2004/018813 patent/WO2005003090A1/en active Application Filing
- 2004-06-10 CN CNB2004800166001A patent/CN100406435C/zh not_active Expired - Fee Related
- 2004-06-10 PE PE2004000578A patent/PE20050282A1/es not_active Application Discontinuation
- 2004-06-10 KR KR1020057023698A patent/KR20060017541A/ko not_active Application Discontinuation
- 2004-06-10 BR BRPI0411358-6A patent/BRPI0411358A/pt not_active IP Right Cessation
- 2004-06-10 JP JP2006533776A patent/JP2007507496A/ja active Pending
- 2004-06-10 AU AU2004253869A patent/AU2004253869B2/en not_active Ceased
- 2004-06-10 MX MXPA05013256A patent/MXPA05013256A/es active IP Right Grant
- 2004-06-10 NZ NZ543805A patent/NZ543805A/en unknown
- 2004-06-10 CN CN2007101399767A patent/CN101108809B/zh not_active Expired - Fee Related
- 2004-06-11 AR ARP040102027A patent/AR044676A1/es unknown
- 2004-06-11 MY MYPI20042271A patent/MY139290A/en unknown
-
2005
- 2005-11-28 IS IS8155A patent/IS8155A/is unknown
- 2005-12-07 ZA ZA200509942A patent/ZA200509942B/en unknown
- 2005-12-09 MA MA28650A patent/MA27852A1/fr unknown
- 2005-12-14 CO CO05126202A patent/CO5650231A2/es not_active Application Discontinuation
-
2006
- 2006-01-12 NO NO20060191A patent/NO20060191L/no not_active Application Discontinuation
- 2006-11-21 US US11/602,802 patent/US7351718B2/en not_active Expired - Lifetime
- 2006-11-21 US US11/602,703 patent/US7351717B2/en not_active Expired - Lifetime
-
2008
- 2008-01-30 US US12/011,935 patent/US7638639B2/en active Active
- 2008-01-30 US US12/011,939 patent/US7615566B2/en active Active
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