BRPI0411358A - derivados de 1-(alquilaminoalquil-pirrolidin-/piperidinil)-2,2-difen ilacetamida como antagonistas de receptor muscarìnico - Google Patents
derivados de 1-(alquilaminoalquil-pirrolidin-/piperidinil)-2,2-difen ilacetamida como antagonistas de receptor muscarìnicoInfo
- Publication number
- BRPI0411358A BRPI0411358A BRPI0411358-6A BRPI0411358A BRPI0411358A BR PI0411358 A BRPI0411358 A BR PI0411358A BR PI0411358 A BRPI0411358 A BR PI0411358A BR PI0411358 A BRPI0411358 A BR PI0411358A
- Authority
- BR
- Brazil
- Prior art keywords
- muscarinic receptor
- alkylaminoalkyl
- piperidinyl
- compounds
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"DERIVADOS DE 1-(ALQUILAMINOALQUIL-PIRROLIDIN-/PIPERIDINIL)2,2-DIFENI LACETAMIDA COMO ANTAGONISTAS DE RECEPTOR MUSCARìNICO". Essa invenção é direcionada a compostos de fórmula (I) : onde R¬ 1¬-R¬ 5¬ e a-e são como definido na especificação; ou um sal ou solvato ou estereoisómero farmaceuticamente aceitável desses. A invenção também se direciona a composições farmacêuticas que contêm tais compostos; processos e intermediários úteis para a preparação de tais compostos; e métodos para tratamento de condições de doença mediadas por receptores muscarínicos usando tais compostos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47845603P | 2003-06-13 | 2003-06-13 | |
PCT/US2004/018813 WO2005003090A1 (en) | 2003-06-13 | 2004-06-10 | 1- (alkylaminoalkyl-pyrolidin-/piperidinyl) -2, 2-diphenylacetamide derivatives as muscarinic receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0411358A true BRPI0411358A (pt) | 2006-07-25 |
Family
ID=33563773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0411358-6A BRPI0411358A (pt) | 2003-06-13 | 2004-06-10 | derivados de 1-(alquilaminoalquil-pirrolidin-/piperidinil)-2,2-difen ilacetamida como antagonistas de receptor muscarìnico |
Country Status (22)
Country | Link |
---|---|
US (5) | US7183292B2 (pt) |
EP (1) | EP1633707A1 (pt) |
JP (1) | JP2007507496A (pt) |
KR (1) | KR20060017541A (pt) |
CN (2) | CN101108809B (pt) |
AR (1) | AR044676A1 (pt) |
AU (1) | AU2004253869B2 (pt) |
BR (1) | BRPI0411358A (pt) |
CA (1) | CA2525801A1 (pt) |
CL (1) | CL2004001431A1 (pt) |
CO (1) | CO5650231A2 (pt) |
IS (1) | IS8155A (pt) |
MA (1) | MA27852A1 (pt) |
MX (1) | MXPA05013256A (pt) |
MY (1) | MY139290A (pt) |
NO (1) | NO20060191L (pt) |
NZ (1) | NZ543805A (pt) |
PE (1) | PE20050282A1 (pt) |
RU (1) | RU2337095C2 (pt) |
TW (1) | TW200510298A (pt) |
WO (1) | WO2005003090A1 (pt) |
ZA (1) | ZA200509942B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200800953A (en) * | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
US7368463B2 (en) * | 2003-07-11 | 2008-05-06 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
WO2005087722A1 (en) * | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
EP1723142A1 (en) * | 2004-03-11 | 2006-11-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
TW200540154A (en) * | 2004-06-10 | 2005-12-16 | Theravance Inc | Crystalline form of a substituted pyrrolidine compound |
GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
BRPI0807615A8 (pt) * | 2007-02-23 | 2017-12-05 | Theravance Inc | Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico |
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US3192221A (en) * | 1961-12-04 | 1965-06-29 | Robins Co Inc A H | 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones and production thereof |
US3192210A (en) * | 1961-12-04 | 1965-06-29 | Robins Co Inc A H | 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones |
US3247222A (en) * | 1962-12-26 | 1966-04-19 | Robins Co Inc A H | Alpha (nu-hydrocarbonpyrrolidyl-3-) alpha, alpha carbocyclic arylacetamides |
US3732247A (en) * | 1970-08-14 | 1973-05-08 | Robins Co Inc A H | 3-di-substituted methylene pyrrolidines wherein the 1-or n-lower-alkyl substituent contains at least two carbon atoms |
US3984557A (en) * | 1974-12-26 | 1976-10-05 | A. H. Robins Company, Incorporated | Antiarrhythmia compositions and methods |
US4002766A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | Antiarrhythmia methods |
BR8007911A (pt) | 1979-12-06 | 1981-06-16 | Glaxo Group Ltd | Inalador aperfeicoado |
JPS57175165A (en) * | 1981-04-21 | 1982-10-28 | Tokyo Tanabe Co Ltd | Novel 1,4-dihydropyridine-3,5-dicarboxylic diester derivative and its salt |
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IL76583A (en) * | 1984-10-19 | 1988-08-31 | Robins Co Inc A H | 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them |
US4594343A (en) * | 1984-10-19 | 1986-06-10 | Shanklin Jr James R | 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
CA1272917A (en) | 1985-07-30 | 1990-08-21 | Paul Kenneth Rand | Devices for administering medicaments to patients |
US4810713A (en) * | 1985-12-20 | 1989-03-07 | A. H. Robins Company, Incorporated | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment |
EP0235463A3 (en) | 1985-12-20 | 1990-01-17 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents |
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TW200800953A (en) * | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
EP1615881A2 (en) | 2003-04-01 | 2006-01-18 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
US7368463B2 (en) | 2003-07-11 | 2008-05-06 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
PE20050973A1 (es) | 2003-10-29 | 2005-11-19 | Theravance Inc | Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos |
EP1723142A1 (en) | 2004-03-11 | 2006-11-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
WO2005087722A1 (en) | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
TW200540154A (en) | 2004-06-10 | 2005-12-16 | Theravance Inc | Crystalline form of a substituted pyrrolidine compound |
-
2004
- 2004-06-03 TW TW093115971A patent/TW200510298A/zh unknown
- 2004-06-09 CL CL200401431A patent/CL2004001431A1/es unknown
- 2004-06-10 RU RU2006101151/04A patent/RU2337095C2/ru not_active IP Right Cessation
- 2004-06-10 CN CN2007101399767A patent/CN101108809B/zh not_active Expired - Fee Related
- 2004-06-10 JP JP2006533776A patent/JP2007507496A/ja active Pending
- 2004-06-10 PE PE2004000578A patent/PE20050282A1/es not_active Application Discontinuation
- 2004-06-10 NZ NZ543805A patent/NZ543805A/en unknown
- 2004-06-10 US US10/865,527 patent/US7183292B2/en active Active
- 2004-06-10 EP EP04776527A patent/EP1633707A1/en not_active Withdrawn
- 2004-06-10 MX MXPA05013256A patent/MXPA05013256A/es active IP Right Grant
- 2004-06-10 WO PCT/US2004/018813 patent/WO2005003090A1/en active Application Filing
- 2004-06-10 AU AU2004253869A patent/AU2004253869B2/en not_active Ceased
- 2004-06-10 KR KR1020057023698A patent/KR20060017541A/ko not_active Application Discontinuation
- 2004-06-10 CA CA002525801A patent/CA2525801A1/en not_active Abandoned
- 2004-06-10 CN CNB2004800166001A patent/CN100406435C/zh not_active Expired - Fee Related
- 2004-06-10 BR BRPI0411358-6A patent/BRPI0411358A/pt not_active IP Right Cessation
- 2004-06-11 AR ARP040102027A patent/AR044676A1/es unknown
- 2004-06-11 MY MYPI20042271A patent/MY139290A/en unknown
-
2005
- 2005-11-28 IS IS8155A patent/IS8155A/is unknown
- 2005-12-07 ZA ZA200509942A patent/ZA200509942B/en unknown
- 2005-12-09 MA MA28650A patent/MA27852A1/fr unknown
- 2005-12-14 CO CO05126202A patent/CO5650231A2/es not_active Application Discontinuation
-
2006
- 2006-01-12 NO NO20060191A patent/NO20060191L/no not_active Application Discontinuation
- 2006-11-21 US US11/602,703 patent/US7351717B2/en not_active Expired - Lifetime
- 2006-11-21 US US11/602,802 patent/US7351718B2/en not_active Expired - Lifetime
-
2008
- 2008-01-30 US US12/011,939 patent/US7615566B2/en active Active
- 2008-01-30 US US12/011,935 patent/US7638639B2/en active Active
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