PE20030883A1 - Acidos alfa-iminocarboxilicos n-sustituidos ciclicos para la inhibicion selectiva de colagenasa - Google Patents

Acidos alfa-iminocarboxilicos n-sustituidos ciclicos para la inhibicion selectiva de colagenasa

Info

Publication number
PE20030883A1
PE20030883A1 PE2003000171A PE2003000171A PE20030883A1 PE 20030883 A1 PE20030883 A1 PE 20030883A1 PE 2003000171 A PE2003000171 A PE 2003000171A PE 2003000171 A PE2003000171 A PE 2003000171A PE 20030883 A1 PE20030883 A1 PE 20030883A1
Authority
PE
Peru
Prior art keywords
alkyl
sulfonil
iminocarboxyl
acids
metalopylophyl
Prior art date
Application number
PE2003000171A
Other languages
English (en)
Inventor
Reinhard Kirsch
Sven Ruf
Klaus-Ulrich Weithmann
Volkmar Wehner
Petra Stahl
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PE20030883A1 publication Critical patent/PE20030883A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE AL USO DE ACIDOS ALFA IMINOCARBOXILICOS N-SUSTITUIDOS CICLICOS DE FORMULA I PARA PRODUCIR UN PRODUCTO FARMACEUTICO PARA LA PROFILAXIS Y TERAPIA DE AFECCIONES EN CUYO AVANCE ESTA IMPLICADA UNA ACTIVIDAD INTENSIFICADA DE METALOPROTEINASA 13 DE LA MATRIZ MMP13 TAL COMO OSTEOARTROSIS, ESPONDILOSIS, CONDROLISIS DESPUES DE UN TRAUMATISMO DE LAS ARTICULACIONES, INMOVILIZACION PROLONGADA DE LAS ARTICULACIONES TRAS LESIONES DE MENISCO O ROTULA O DESGARRO DE LIGAMENTOS, COLAGENOSIS, AFECCIONES PERIODONTALES, TRASTORNOS EN LA CURACION DE HERIDAS, AFECCION CRONICA DEL SISTEMA LOCOMOTOR COMO ARTRITIS AGUDA, CRONICA, INFLAMATORIA, INMUNOLOGICA RELACIONADA CON EL METABOLISMO, ARTROPATIAS; DONDE A ES CARBONO, NITROGENO OPCIONALMENTE SUSTITUIDO CON ALQUILO; n ES 1-2; R1 ES ALQUILO, ALQUENILO, ALQUINILO, ALQUIL-FENILO, ALQUIL-CICLOALQUILO, CICLOALQUILO, CH2CF3; R2 ES H, ALQUILO. TAMBIEN SE REFIERE AL COMPUESTO I, ENTRE OTROS Y A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS ACIDO 2-(4'-NITROBIFENIL-4-SULFONIL)-1,2,3,4-TETRAHIDRO-ISOQUINOLIN-3-(R)-CARBOXILICO; 2-(4'-AMINOBIFENIL-4-SULFONIL)-1,2,3,4-TETRAHIDRO-ISOQUINOLINIL-3-(R)-CARBOXILATO DE METILO; 2-(4'-ISOPROPOXICARBONILAMINOBIFENIL-4-SULFONIL)-1,2,3,4-TETRAHIDROISOQUINOLIN-3-(R)-CARBOXILATO DE METILO
PE2003000171A 2002-03-02 2003-02-18 Acidos alfa-iminocarboxilicos n-sustituidos ciclicos para la inhibicion selectiva de colagenasa PE20030883A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10209299A DE10209299A1 (de) 2002-03-02 2002-03-02 Cyclische N-substituierte alpha-Iminocarbonsäuren zur selektiven Inhibierung von Kollagenase

Publications (1)

Publication Number Publication Date
PE20030883A1 true PE20030883A1 (es) 2003-12-05

Family

ID=27762622

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000171A PE20030883A1 (es) 2002-03-02 2003-02-18 Acidos alfa-iminocarboxilicos n-sustituidos ciclicos para la inhibicion selectiva de colagenasa

Country Status (11)

Country Link
EP (1) EP1483244B1 (es)
JP (1) JP4520744B2 (es)
AR (1) AR038857A1 (es)
AU (1) AU2003214063A1 (es)
BR (1) BR0308088A (es)
CA (1) CA2477474C (es)
DE (1) DE10209299A1 (es)
MX (1) MXPA04007844A (es)
PE (1) PE20030883A1 (es)
TW (1) TW200400178A (es)
WO (1) WO2003074489A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005002500A1 (de) * 2005-01-19 2006-07-27 Sanofi-Aventis Deutschland Gmbh Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
DE102005015040A1 (de) * 2005-03-31 2006-10-05 Sanofi-Aventis Deutschland Gmbh Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE213232T1 (de) 1995-11-13 2002-02-15 Hoechst Ag Cyclische und heterocyclische n-substituierte alpha-iminohydroxam- und carbonsäuren

Also Published As

Publication number Publication date
JP2005528350A (ja) 2005-09-22
JP4520744B2 (ja) 2010-08-11
AR038857A1 (es) 2005-01-26
AU2003214063A1 (en) 2003-09-16
EP1483244B1 (de) 2013-04-10
CA2477474A1 (en) 2003-09-12
DE10209299A1 (de) 2003-09-18
TW200400178A (en) 2004-01-01
CA2477474C (en) 2010-11-16
WO2003074489A1 (de) 2003-09-12
EP1483244A1 (de) 2004-12-08
MXPA04007844A (es) 2004-10-15
BR0308088A (pt) 2004-12-21

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