PE20030748A1 - Derivados sustituidos del 2-pirrolidin-2-ilo-1h-indol - Google Patents

Derivados sustituidos del 2-pirrolidin-2-ilo-1h-indol

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Publication number
PE20030748A1
PE20030748A1 PE2002001168A PE2002001168A PE20030748A1 PE 20030748 A1 PE20030748 A1 PE 20030748A1 PE 2002001168 A PE2002001168 A PE 2002001168A PE 2002001168 A PE2002001168 A PE 2002001168A PE 20030748 A1 PE20030748 A1 PE 20030748A1
Authority
PE
Peru
Prior art keywords
alkyl
ilo
indol
cycloalkyl
pyrrolidin
Prior art date
Application number
PE2002001168A
Other languages
English (en)
Inventor
Corinna Sundermann
Bernd Sundermann
Hagen-Heinrich Hennies
Helmut Buschmann
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20030748A1 publication Critical patent/PE20030748A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Abstract

SE REFIERE A DERIVADOS SUSTITUIDOS DEL 2-PIRROLIDIN-2-ILO-1H-INDOL EN FORMA DE SUS RACEMATOS, ESTEREOISOMEROS PUROS, ENANTIOMEROS DE FORMULA I DONDE R1 ES H, ALQUILO, CICLOALQUILO, ALQUIL-CICLOALQUILO, ALQUIL-ARILO, ALQUIL HETEROCICLILO, ENTRE OTROS; R2 ES H, ALQUILO, CICLOALQUILO, ALQUILO-CICLOALQUILO, ALQUIL-ARILO, C(=O)-R20, ENTRE OTROS; R3 ES ALQUILO, ARILO, HETEROCICLO; R4 ES H, F, Cl, Br, I, -CN, ALQUILO, ENTRE OTROS; R20 ES ALQUILO, CICLOALQUILO, ALQUILO-CICLOALQUILO, ARILO, ALQUILARILO, ENTRE OTROS SIENDO EXCLUIDOS LOS SIGUIENTES COMPUESTOS 2-(3-FENIL-1H-INDOL-2-ILO)-1-(TRIFLUOROACETIL)-PIRROLIDINA, ESTER METILICO DEL ACIDO O-METIL-2-(1-METIL-2-PIRROLIDINIL)-INDOL-3-ACETICO, 3-(1-CIANOETIL)-(1-METIL-2-PIRROLIDINIL)-INDOL Y 2-(1-METIL-2-PIRROLIDINIL)-3-VINILINDOL. SON COMPUESTOS PREFERIDOS {2-[5-CLORO-1-(2-DIETILAMINO-ETIL)-3-FENIL-1H-INDOL-2-ILO]-PIRROLIDIN-1-ILO}FURAN-2-ILO-METANONA, ESTER METILICO DEL ACIDO 4-{2-[5-CLORO-1-(2-DIETILAMINO-ETIL)-3-FENIL-1H-INDOL-2-ILO]-PIRROLIDIN-1-ILO}-4-OXO-BUTANOICO, {2-[5-CLORO-1-(2-DIETILAMINO-ETIL)-3-FENIL-1H-INDOL-2-ILO]-PIRROLIDIN-1-ILO}-CICLOBUTIL-METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. LOS COMPUESTOS MENCIONADOS INHIBEN LA NO-SINTASA Y SON UTILES PARA EL TRATAMIENTO DE LA MIGRANA, ESCLEROSIS, PARKINSON, ALZHEIMER
PE2002001168A 2001-12-06 2002-12-04 Derivados sustituidos del 2-pirrolidin-2-ilo-1h-indol PE20030748A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10159922A DE10159922A1 (de) 2001-12-06 2001-12-06 Substituierte 2-Pyrrolidin-2-yl-1H-indol-Derivate

Publications (1)

Publication Number Publication Date
PE20030748A1 true PE20030748A1 (es) 2003-09-05

Family

ID=7708242

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001168A PE20030748A1 (es) 2001-12-06 2002-12-04 Derivados sustituidos del 2-pirrolidin-2-ilo-1h-indol

Country Status (18)

Country Link
US (1) US7271192B2 (es)
EP (1) EP1451177B1 (es)
JP (1) JP4663982B2 (es)
AR (1) AR037707A1 (es)
AT (1) ATE357441T1 (es)
AU (1) AU2002363859B2 (es)
CA (1) CA2469346C (es)
CY (1) CY1106576T1 (es)
DE (2) DE10159922A1 (es)
DK (1) DK1451177T3 (es)
ES (1) ES2284973T3 (es)
HU (1) HUP0402283A3 (es)
MX (1) MXPA04005139A (es)
PE (1) PE20030748A1 (es)
PL (1) PL371270A1 (es)
PT (1) PT1451177E (es)
SI (1) SI1451177T1 (es)
WO (1) WO2003048156A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2385702T3 (es) 2005-06-07 2012-07-30 Kyowa Hakko Kirin Co., Ltd. Antagonistas de A2A para uso en el tratamiento de trastornos de la motricidad
MY159958A (en) * 2009-12-18 2017-02-15 Idenix Pharmaceuticals Inc 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
CN112010841A (zh) * 2020-08-20 2020-12-01 上海体育学院 一种基于吲哚骨架的吡咯烷衍生物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506683A (en) * 1963-10-07 1970-04-14 Upjohn Co 3-(2-pyrrolidinylidene)-3h-indoles
ES2143992T3 (es) * 1991-11-25 2000-06-01 Pfizer Derivados de 5-(hetero- o carbociclilamino)-indol, su preparacion y uso como 5-ht1 agonistas.
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
DK0716649T3 (da) * 1993-08-31 1999-02-08 Pfizer 5-Arylindolderivater
GB9523999D0 (en) * 1995-11-23 1996-01-24 Lilly Co Eli Indolyl neuropeptide y receptor antagonists
HN1998000118A (es) * 1997-08-27 1999-02-09 Pfizer Prod Inc 2 - aminopiridinas que contienen sustituyentes de anillos condensados.
KR20030060904A (ko) * 2000-10-06 2003-07-16 뉴로젠 코포레이션 Ｃｒｆ 수용체 조절자로서 벤즈이미다졸 및 인돌 유도체

Also Published As

Publication number Publication date
ES2284973T3 (es) 2007-11-16
EP1451177A1 (de) 2004-09-01
CY1106576T1 (el) 2012-01-25
DK1451177T3 (da) 2007-07-02
PT1451177E (pt) 2007-04-30
JP2005511694A (ja) 2005-04-28
WO2003048156A1 (de) 2003-06-12
PL371270A1 (en) 2005-06-13
US20050014815A1 (en) 2005-01-20
AU2002363859A1 (en) 2003-06-17
CA2469346C (en) 2010-10-19
US7271192B2 (en) 2007-09-18
DE10159922A1 (de) 2003-06-26
CA2469346A1 (en) 2003-06-12
HUP0402283A2 (hu) 2005-02-28
ATE357441T1 (de) 2007-04-15
JP4663982B2 (ja) 2011-04-06
AU2002363859B2 (en) 2008-09-18
HUP0402283A3 (en) 2009-07-28
SI1451177T1 (sl) 2007-08-31
EP1451177B1 (de) 2007-03-21
MXPA04005139A (es) 2004-08-11
AR037707A1 (es) 2004-12-01
DE50209798D1 (de) 2007-05-03

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