PE20030614A1 - Benzo [b] azepin-2-ona sustitudas - Google Patents

Benzo [b] azepin-2-ona sustitudas

Info

Publication number
PE20030614A1
PE20030614A1 PE2002001056A PE2002001056A PE20030614A1 PE 20030614 A1 PE20030614 A1 PE 20030614A1 PE 2002001056 A PE2002001056 A PE 2002001056A PE 2002001056 A PE2002001056 A PE 2002001056A PE 20030614 A1 PE20030614 A1 PE 20030614A1
Authority
PE
Peru
Prior art keywords
azepin
benzo
ona
substitutes
alkyl
Prior art date
Application number
PE2002001056A
Other languages
English (en)
Inventor
Helmut Buschmann
Werner Englberger
Hans Schick
Michael Przewosny
Michael Sattlegger
Babette-Yvonne Kogel
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20030614A1 publication Critical patent/PE20030614A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIEREN A BENZO [B] AZEPIN-2-ONA SUSTITUDAS DE FORMULA I Y II DONDE R1-R4 SON ALQUILO C1-C10, CICLOALQUILO C3-C7 PUDIENDO ESTAR ENLAZADO CON PUENTES DE ETER, H, OH, HALOGENO; R5 ES H, ALQUILO C1-C10, ARILO, HETEROARILO; R6 ES H, UN RADICAL DE FORMULA -CH2-N(R7)2 DONDE AMBOS RADICALES PUEDEN SER DISTINTOS O CONJUNTAMENTE CON N FORMAN UN CICLO DE 3-8 MIEMBROS; R7 ES ALQUILO C1-C6; A ES -(CH)n+2-, -(CH2)n-CH=CH-, -(CH2)nCOO-, ENTRE OTROS; X ES UN HETEROCICLO. SON COMPUESTOS PREFERIDOS 2'-(8-CLORO-2-OXO-2,3-DIHIDRO-1H-BENZO[b]AZEPIN-5-IL]ACETATO DE [3''-(N,N-DIMETILAMINOMETIL)-4''-HIDROXI-4''-(m-METOXIFENIL)CICLOHEXILO], 2'-(8-CLORO-2-OXO-2,3-DIHIDRO-1H-BENZO[b]AZEPIN-5-IL]-N-[3''-(N,N-DIMETILAMINOMETIL)-4''-HIDROXI-4''-(m-METOXIFENIL)CICLOHEXIL-ACETAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON UTILES EN EL TRATAMIENTO DEL DOLOR
PE2002001056A 2001-10-29 2002-10-28 Benzo [b] azepin-2-ona sustitudas PE20030614A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10153348A DE10153348A1 (de) 2001-10-29 2001-10-29 Substituierte Benzo(b)azepin-2-on-Verbindungen

Publications (1)

Publication Number Publication Date
PE20030614A1 true PE20030614A1 (es) 2003-07-26

Family

ID=7704098

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001056A PE20030614A1 (es) 2001-10-29 2002-10-28 Benzo [b] azepin-2-ona sustitudas

Country Status (15)

Country Link
US (1) US7041662B2 (es)
EP (1) EP1444206B1 (es)
JP (1) JP2005511570A (es)
AR (1) AR037124A1 (es)
AT (1) ATE320418T1 (es)
CA (1) CA2464191A1 (es)
CY (1) CY1105039T1 (es)
DE (2) DE10153348A1 (es)
DK (1) DK1444206T3 (es)
ES (1) ES2260487T3 (es)
HU (1) HUP0401762A2 (es)
PE (1) PE20030614A1 (es)
PL (1) PL369852A1 (es)
PT (1) PT1444206E (es)
WO (1) WO2003037873A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013072B1 (ru) * 2004-05-12 2010-02-26 Байер Кропсайенс Аг Применение конденсированных производных азепинона для регулирования роста растений, композиция для регулирования роста растений и ее применение и способ регулирования роста растений
CA2566396A1 (en) * 2004-05-12 2005-11-17 Bayer Cropscience Gmbh Plant growth regulation
SE531698C2 (sv) 2007-07-12 2009-07-07 Respiratorius Ab Nya bronkdilaterande a,b-omättade amider
HUE060259T2 (hu) 2015-07-22 2023-02-28 Enanta Pharm Inc Benzodiazepin származékok mint RSV-gátlók
KR20210138684A (ko) 2019-03-18 2021-11-19 이난타 파마슈티칼스, 인코포레이티드 Rsv 억제제로서의 벤조디아제핀 유도체
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
CN112759545B (zh) * 2019-11-06 2022-12-13 复旦大学 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途
CN112759546B (zh) * 2019-11-06 2022-08-26 复旦大学 3-(二甲氨基甲基)哌啶-4-醇衍生物及其制备方法和药物用途
CN112759544B (zh) * 2019-11-06 2022-08-26 复旦大学 3-(二甲氨基甲基)哌啶-4-醇衍生物制备方法和药物用途
CN112759587B (zh) * 2019-11-06 2022-12-30 复旦大学 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途
US20230027752A1 (en) * 2019-11-06 2023-01-26 Fudan University Opioid receptor agonist, preparation method therefor and pharmaceutical use thereof
WO2022086840A1 (en) 2020-10-19 2022-04-28 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3475414A (en) * 1966-12-05 1969-10-28 Miles Lab Tetrahydro-1-benzazepin-2(1h)-one derivatives
TW213901B (es) * 1992-01-27 1993-10-01 Pfizer
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe

Also Published As

Publication number Publication date
CA2464191A1 (en) 2003-05-08
JP2005511570A (ja) 2005-04-28
WO2003037873A1 (de) 2003-05-08
HUP0401762A2 (hu) 2004-12-28
US7041662B2 (en) 2006-05-09
DK1444206T3 (da) 2006-07-24
PL369852A1 (en) 2005-05-02
EP1444206B1 (de) 2006-03-15
CY1105039T1 (el) 2010-03-03
ATE320418T1 (de) 2006-04-15
DE50206096D1 (de) 2006-05-11
US20040224938A1 (en) 2004-11-11
PT1444206E (pt) 2006-07-31
DE10153348A1 (de) 2003-05-08
ES2260487T3 (es) 2006-11-01
AR037124A1 (es) 2004-10-20
EP1444206A1 (de) 2004-08-11

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