PE20010320A1 - Antagonistas de los receptores de la il-8 - Google Patents

Antagonistas de los receptores de la il-8

Info

Publication number
PE20010320A1
PE20010320A1 PE2000000592A PE0005922000A PE20010320A1 PE 20010320 A1 PE20010320 A1 PE 20010320A1 PE 2000000592 A PE2000000592 A PE 2000000592A PE 0005922000 A PE0005922000 A PE 0005922000A PE 20010320 A1 PE20010320 A1 PE 20010320A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
heteroaryl
group
receptors
Prior art date
Application number
PE2000000592A
Other languages
English (en)
Inventor
Katherine L Widdowson
John G Gleason
Gregory M Benson
Deborah L Bryan
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20010320A1 publication Critical patent/PE20010320A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE AL USO DE COMPUESTOS DE GUANIDINA DE FORMULA I, DONDE: Z ES CIANO, OR11, C(O)NR15R16, R18, C(O)R11, S(O)2R17; 1-2 A SON N, Y EL RESTO SON C SUSTITUIDO CON H o R1; R ES UN GRUPO CON H IONIZABLE CON UN PKa DE 10 O MENOS; R1 ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10 HALOSUSTITUIDO, ALCOXI C1-C10; AZIDA, (CR8R8)qS(O)tR4, (CR8R8)qNR4R5, ENTRE OTROS; q ES 0-10; t ES 0-2; v ES 1-4; m ES 1-3; R4 Y R5 SON H, ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, ENTRE OTROS; Y ES H, HALOGENO, NITRO, CIANO, ENTRE OTROS; R8 ES H, ALQUILO C1-C4; R11 ES H, ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4; HETEROARILO, ENTRE OTROS; R13 Y R14 SON H, ALQUILO C1-C4; R15 Y R16 SON H, ALQUILO C1-C4, ARIL-ALQUILO C1-C4, HETEROARILO, HETEROARIL-ALQUILO C1-C4, ENTRE OTROS; R17 ES ALQUILO C1-C4, NR15R16, OR11, ARILO, ARIL-ALQUILO C1-C4, HETEROARILO, ENTRE OTROS; R18 ES ALQUILO C1-C4, ARILO, ARIL-ALQUILO C1-C4, ENTRE OTROS; W1 ES UN GRUPO a, ENTRE OTROS; E ES UN GRUPO b, ENTRE OTROS; EL * ES EL PUNTO DE UNION DEL ANILLO. LOS COMPUESTOS I INHIBEN LA UNION DE LAS QUIMIOQUINAS GROO, GROß, GROÛ, NAP-2 A LOS RECEPTORES O o ß DE LA INTERLEUQUINA 8 IL-8 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE MALARIA, RESTENOSIS, ANGIOGENESIS, ATEROSCLEROSIS, OSTEOPOROSIS, GINGIVITIS, HERPESVIRUS, VIRUS DE LA HEPATITIS
PE2000000592A 1999-06-16 2000-06-14 Antagonistas de los receptores de la il-8 PE20010320A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14002599P 1999-06-16 1999-06-16

Publications (1)

Publication Number Publication Date
PE20010320A1 true PE20010320A1 (es) 2001-05-18

Family

ID=22489384

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000592A PE20010320A1 (es) 1999-06-16 2000-06-14 Antagonistas de los receptores de la il-8

Country Status (6)

Country Link
AU (1) AU5622400A (es)
CO (1) CO5190720A1 (es)
EC (1) ECSP003529A (es)
PE (1) PE20010320A1 (es)
UY (1) UY26208A1 (es)
WO (1) WO2000076508A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1917244A2 (de) 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684032A (en) * 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
EP1021181A4 (en) * 1996-03-28 2002-06-26 Smithkline Beecham Corp INDOLCARBOXYLIC ACIDS AS CHEMOKIN INHIBITORS

Also Published As

Publication number Publication date
WO2000076508A1 (en) 2000-12-21
UY26208A1 (es) 2000-12-29
CO5190720A1 (es) 2002-08-29
AU5622400A (en) 2001-01-02
ECSP003529A (es) 2002-01-25

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Legal Events

Date Code Title Description
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