PE20001059A1 - Derivados de benzamida como inhibidores de la trombina - Google Patents
Derivados de benzamida como inhibidores de la trombinaInfo
- Publication number
- PE20001059A1 PE20001059A1 PE1999000995A PE00099599A PE20001059A1 PE 20001059 A1 PE20001059 A1 PE 20001059A1 PE 1999000995 A PE1999000995 A PE 1999000995A PE 00099599 A PE00099599 A PE 00099599A PE 20001059 A1 PE20001059 A1 PE 20001059A1
- Authority
- PE
- Peru
- Prior art keywords
- benzamide
- ilamino
- pyridin
- alkyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE AMIDA DE FORMULA I DONDE R1 ES ALQUILO C1-C4, CICLOALQUILO C3-C8; R2 ES ALQUILO C1-C4, ALQUENILO C3-C4; R3 ES H, ALQUILO C1-C3, HALOGENO; R4 ES ALQUILO C1-C6. SON COMPUESTOSS PREFERIDOS N-ETIL-N-ISOPROPIL-3-METIL-5-[2S-(PIRIDIN-4-ILAMINO)-PROPOXI]-BENZAMIDA; N,N-DIISOPROPIL-3-METIL-5-[2S-(PIRIDIN-4-ILAMINO)-PROPOXI]-BENZAMIDA; N-ISOPROPIL-3,N-DIMETIL-5-[2S-(PIRIDIN-4-ILAMINO)-PROPROXI]-BENZAMIDA; 3,N-DIMETIL-N-PROPIL-5-[2S-(PIRIDIN-4-ILAMINO)-PROPOXI]BENZAMIDA; 3-METIL-N,N-DIPROPIL-5-[2S-(PIRIDIN-4-ILAMINO)-PROPOXI]-BENZAMIDA; N-ETIL-3-METIL-N-PROPIL-5-[2S-(PIRIDIN-4-ILAMINO)-PROPOXI]-BENZAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE LA TROMBINA POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO ENFERMEDADES VASCULARES AGUDAS, TROMBOSIS CORONARIA, ATAQUE, EMBOLIA PULMONAR, TROMBOSIS VENOSA PROFUNDA, INFARTO DE MIOCARDIO, ANGINA INESTABLE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821483.6A GB9821483D0 (en) | 1998-10-03 | 1998-10-03 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001059A1 true PE20001059A1 (es) | 2000-10-23 |
Family
ID=10839873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000995A PE20001059A1 (es) | 1998-10-03 | 1999-09-30 | Derivados de benzamida como inhibidores de la trombina |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6441008B1 (es) |
| EP (1) | EP1117644A1 (es) |
| JP (1) | JP3457281B2 (es) |
| KR (1) | KR20010075546A (es) |
| CN (1) | CN1328548A (es) |
| AR (1) | AR023332A1 (es) |
| AU (1) | AU758007B2 (es) |
| BR (1) | BR9914267A (es) |
| CA (1) | CA2345997A1 (es) |
| CO (1) | CO5140085A1 (es) |
| CZ (1) | CZ20011216A3 (es) |
| GB (1) | GB9821483D0 (es) |
| HU (1) | HUP0103744A3 (es) |
| IL (1) | IL142301A0 (es) |
| MA (1) | MA26695A1 (es) |
| NO (1) | NO20011654L (es) |
| NZ (1) | NZ510839A (es) |
| PE (1) | PE20001059A1 (es) |
| PL (1) | PL347152A1 (es) |
| TR (1) | TR200100906T2 (es) |
| WO (1) | WO2000020394A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117144D0 (en) * | 2001-07-13 | 2001-09-05 | Glaxo Group Ltd | Process |
| DK1637141T3 (da) | 2004-09-21 | 2012-02-27 | Trobio Ab | Stabiliseret proteasesammensætning omfattende en serinprotease, morpholinderivater og reversible inhibitorer af serinproteasen |
| CA2621059C (en) * | 2005-09-22 | 2013-08-13 | Trobio Ab | Stabilized protease composition |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW257757B (es) | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| NZ262941A (en) | 1993-03-29 | 1997-07-27 | Zeneca Ltd | Pyridine derivatives and medicaments |
| GB9525620D0 (en) | 1995-12-15 | 1996-02-14 | Glaxo Group Ltd | Chemical compounds |
-
1998
- 1998-10-03 GB GBGB9821483.6A patent/GB9821483D0/en not_active Ceased
-
1999
- 1999-09-29 AR ARP990104910A patent/AR023332A1/es not_active Application Discontinuation
- 1999-09-30 CZ CZ20011216A patent/CZ20011216A3/cs unknown
- 1999-09-30 WO PCT/EP1999/007194 patent/WO2000020394A1/en not_active Application Discontinuation
- 1999-09-30 US US09/806,407 patent/US6441008B1/en not_active Expired - Fee Related
- 1999-09-30 CA CA002345997A patent/CA2345997A1/en not_active Abandoned
- 1999-09-30 CN CN99813786A patent/CN1328548A/zh active Pending
- 1999-09-30 EP EP99952472A patent/EP1117644A1/en not_active Withdrawn
- 1999-09-30 PL PL99347152A patent/PL347152A1/xx not_active Application Discontinuation
- 1999-09-30 KR KR1020017004191A patent/KR20010075546A/ko not_active Application Discontinuation
- 1999-09-30 AU AU64670/99A patent/AU758007B2/en not_active Ceased
- 1999-09-30 NZ NZ510839A patent/NZ510839A/en unknown
- 1999-09-30 CO CO99061898A patent/CO5140085A1/es unknown
- 1999-09-30 PE PE1999000995A patent/PE20001059A1/es not_active Application Discontinuation
- 1999-09-30 JP JP2000574511A patent/JP3457281B2/ja not_active Expired - Fee Related
- 1999-09-30 TR TR2001/00906T patent/TR200100906T2/xx unknown
- 1999-09-30 HU HU0103744A patent/HUP0103744A3/hu unknown
- 1999-09-30 IL IL14230199A patent/IL142301A0/xx unknown
- 1999-09-30 BR BR9914267-8A patent/BR9914267A/pt not_active IP Right Cessation
- 1999-10-01 MA MA25797A patent/MA26695A1/fr unknown
-
2001
- 2001-04-02 NO NO20011654A patent/NO20011654L/no not_active Application Discontinuation
-
2002
- 2002-01-10 US US10/044,769 patent/US6670381B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3457281B2 (ja) | 2003-10-14 |
| CA2345997A1 (en) | 2000-04-13 |
| JP2002526531A (ja) | 2002-08-20 |
| BR9914267A (pt) | 2001-07-03 |
| AU758007B2 (en) | 2003-03-13 |
| US20020169189A1 (en) | 2002-11-14 |
| GB9821483D0 (en) | 1998-11-25 |
| PL347152A1 (en) | 2002-03-25 |
| AU6467099A (en) | 2000-04-26 |
| NO20011654D0 (no) | 2001-04-02 |
| MA26695A1 (fr) | 2004-12-20 |
| WO2000020394A1 (en) | 2000-04-13 |
| NZ510839A (en) | 2003-08-29 |
| US6441008B1 (en) | 2002-08-27 |
| KR20010075546A (ko) | 2001-08-09 |
| TR200100906T2 (tr) | 2001-07-23 |
| AR023332A1 (es) | 2002-09-04 |
| HUP0103744A3 (en) | 2002-03-28 |
| US6670381B2 (en) | 2003-12-30 |
| NO20011654L (no) | 2001-05-30 |
| HUP0103744A2 (hu) | 2002-02-28 |
| EP1117644A1 (en) | 2001-07-25 |
| CZ20011216A3 (cs) | 2001-09-12 |
| CO5140085A1 (es) | 2002-03-22 |
| IL142301A0 (en) | 2002-03-10 |
| CN1328548A (zh) | 2001-12-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |