PE20001022A1 - Compuestos de pirazina - Google Patents
Compuestos de pirazinaInfo
- Publication number
- PE20001022A1 PE20001022A1 PE1999000868A PE00086899A PE20001022A1 PE 20001022 A1 PE20001022 A1 PE 20001022A1 PE 1999000868 A PE1999000868 A PE 1999000868A PE 00086899 A PE00086899 A PE 00086899A PE 20001022 A1 PE20001022 A1 PE 20001022A1
- Authority
- PE
- Peru
- Prior art keywords
- disorders
- pirazine
- compounds
- alkyl
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DE PIRAZINA DE FORMULA I, DONDE R1 ES FENILO SUSTITUIDO POR HALOGENO DE PREFERENCIA TRICLOROFENILO; R2 ES NH2; R3 ES NH2, H; R4 ES CXNRaRb, CXNH-(CH2)y-NRaRb; X ES =O, =S; y ES 0-2; Ra Y Rb SON H, ALQUILO C1-C4 O JUNTO CON N FORMAN UN HETEROCICLO DE 5-6 MIEMBROS CON 1-2 N OPCIONALMENTE SUSTITUIDOS CON UNO O MAS ALQUILO C1-C4. UN COMPUESTO PREFERIDO ES 2,6-DIAMINO-5-CARBOXAMIDO-3-(2,3,5-TRICLOROFENIL)PIRAZINA. TAMBIEN SE REFIERE A UN PROCESO PARA LA PREPARACION. EL COMPUESTO I ES UN BLOQUEADOR DEL CANAL DE SODIO Y PUEDE SER UTIL PARA EL TRATAMIENTO DE EPILEPSIA, TRASTORNO BIPOLAR, DEPRESION MANIACA, DEPRESION UNIPOLAR, DOLOR, TRASTORNOS EN LA FUNCION DEL INTESTINO, TRASTORNOS NEURODEGENERATIVOS, NEUROPROTECCION, NEURODEGENERACION, ZUMBIDO DEL OIDO; TOLERANCIA INVERSA, UN AGENTE INDUCTOR DE DEPENDENCIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9818881.6A GB9818881D0 (en) | 1998-08-28 | 1998-08-28 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20001022A1 true PE20001022A1 (es) | 2000-10-16 |
Family
ID=10838055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999000868A PE20001022A1 (es) | 1998-08-28 | 1999-08-26 | Compuestos de pirazina |
Country Status (15)
Country | Link |
---|---|
US (2) | US6503909B1 (es) |
EP (1) | EP1107960A1 (es) |
JP (1) | JP2002523499A (es) |
KR (1) | KR20010079696A (es) |
CN (1) | CN1324349A (es) |
AU (1) | AU5624999A (es) |
BR (1) | BR9913183A (es) |
CA (1) | CA2341543A1 (es) |
CO (1) | CO5130006A1 (es) |
GB (1) | GB9818881D0 (es) |
MA (1) | MA26681A1 (es) |
PE (1) | PE20001022A1 (es) |
TR (1) | TR200100603T2 (es) |
TW (1) | TW429255B (es) |
WO (1) | WO2000012488A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA006938B1 (ru) | 2000-02-16 | 2006-06-30 | Ньюроджин Корпорейшн | Замещенные арилпиразины |
EP1500653A1 (en) * | 2000-02-16 | 2005-01-26 | Neurogen Corporation | Substituted arylpyrazines |
GB0010971D0 (en) * | 2000-05-05 | 2000-06-28 | Glaxo Group Ltd | Process |
US7704995B2 (en) | 2002-05-03 | 2010-04-27 | Exelixis, Inc. | Protein kinase modulators and methods of use |
JP4901102B2 (ja) * | 2002-05-03 | 2012-03-21 | エクセリクシス, インク. | プロテインキナーゼモジュレーターおよびその使用方法 |
JP2006509729A (ja) | 2002-08-20 | 2006-03-23 | ニューロジェン・コーポレーション | Crf受容体モジュレータとしての5−置換−2−アリールピラジン類 |
CA2529623A1 (en) * | 2003-06-16 | 2005-02-17 | Celltech R & D, Inc. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
US20070287677A1 (en) * | 2004-03-30 | 2007-12-13 | Genomldea Inc. | Rad51 Expression Inhibitors, Pharmaceutical Agents Containing The Inhibitors As Active Ingredients, And Uses Thereof |
US7592429B2 (en) * | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
EP2094731A2 (en) * | 2006-11-10 | 2009-09-02 | UCB Pharma S.A. | Anti human sclerostin antibodies |
EP2097450A2 (en) * | 2006-11-10 | 2009-09-09 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
CL2008002775A1 (es) * | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
KR20100101656A (ko) * | 2007-12-14 | 2010-09-17 | 암젠 인크 | 항-스클레로스틴 항체를 사용한 골절 치료 방법 |
KR20230135541A (ko) * | 2022-03-16 | 2023-09-25 | (주)아름테라퓨틱스 | 신규한 화합물 및 이의 체크포인트 키나제 2 저해 용도 |
CN115611700B (zh) * | 2022-10-11 | 2024-06-14 | 辽宁东大光明化工科技有限责任公司 | 一种1-溴-2,5-二氯-3-氟苯的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3575975A (en) | 1968-07-25 | 1971-04-20 | Merck & Co Inc | Process for the preparation of 3-aminopyrazinoylureas |
US3544568A (en) * | 1969-03-18 | 1970-12-01 | Merck & Co Inc | 3-amino-5,6-substituted pyrazinamides |
US4402958A (en) | 1981-11-19 | 1983-09-06 | American Cyanamid Company | Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates |
MA26473A1 (fr) | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
-
1998
- 1998-08-28 GB GBGB9818881.6A patent/GB9818881D0/en not_active Ceased
-
1999
- 1999-08-26 TR TR2001/00603T patent/TR200100603T2/xx unknown
- 1999-08-26 US US09/762,295 patent/US6503909B1/en not_active Expired - Fee Related
- 1999-08-26 CA CA002341543A patent/CA2341543A1/en not_active Abandoned
- 1999-08-26 WO PCT/EP1999/006248 patent/WO2000012488A1/en not_active Application Discontinuation
- 1999-08-26 JP JP2000567518A patent/JP2002523499A/ja active Pending
- 1999-08-26 PE PE1999000868A patent/PE20001022A1/es not_active Application Discontinuation
- 1999-08-26 KR KR1020017002509A patent/KR20010079696A/ko not_active Application Discontinuation
- 1999-08-26 BR BR9913183-8A patent/BR9913183A/pt not_active Application Discontinuation
- 1999-08-26 AU AU56249/99A patent/AU5624999A/en not_active Abandoned
- 1999-08-26 CN CN99812550A patent/CN1324349A/zh active Pending
- 1999-08-26 EP EP99942919A patent/EP1107960A1/en not_active Withdrawn
- 1999-08-27 CO CO99054338A patent/CO5130006A1/es unknown
- 1999-08-27 TW TW088114723A patent/TW429255B/zh not_active IP Right Cessation
- 1999-08-27 MA MA25746A patent/MA26681A1/fr unknown
-
2002
- 2002-08-12 US US10/216,399 patent/US20030022904A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CO5130006A1 (es) | 2002-02-27 |
AU5624999A (en) | 2000-03-21 |
BR9913183A (pt) | 2001-05-15 |
US20030022904A1 (en) | 2003-01-30 |
CA2341543A1 (en) | 2000-03-09 |
US6503909B1 (en) | 2003-01-07 |
WO2000012488A1 (en) | 2000-03-09 |
KR20010079696A (ko) | 2001-08-22 |
EP1107960A1 (en) | 2001-06-20 |
TW429255B (en) | 2001-04-11 |
TR200100603T2 (tr) | 2001-07-23 |
GB9818881D0 (en) | 1998-10-21 |
JP2002523499A (ja) | 2002-07-30 |
MA26681A1 (fr) | 2004-12-20 |
CN1324349A (zh) | 2001-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |