PE20000439A1 - Proceso para hacer ureas 1,3-disustituidas-4-oxociclicas - Google Patents
Proceso para hacer ureas 1,3-disustituidas-4-oxociclicasInfo
- Publication number
- PE20000439A1 PE20000439A1 PE1999000354A PE00035499A PE20000439A1 PE 20000439 A1 PE20000439 A1 PE 20000439A1 PE 1999000354 A PE1999000354 A PE 1999000354A PE 00035499 A PE00035499 A PE 00035499A PE 20000439 A1 PE20000439 A1 PE 20000439A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- make
- alkyl
- disustituid
- ureas
- Prior art date
Links
- 150000003672 ureas Chemical class 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000003440 anti-fibrillation Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Catalysts (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
PROCESO PARA HACER UREAS 1,3-DISUSTITUIDAS-4-OXICICLICAS DE FORMULA GENERAL (I), EN DONDE : i) R1, R2 Y R3 PUEDEN SER DE PREFERENCIA H, Cl, F, Br, NH2, COOH, CH3SO2NH, SO3H, OH, ALCOXI, ALQUILO, ALCOXICARBONILO, HIDROXIALQUILO, CARBOXIALQUILO Y ACILOXI; ii) R4 PUEDE SER ALQUILO, ALQUENILO, ALQUINILO, ALQUILACILO Y HETEROALQUILO SUSTITUIDO O NO; iii) A ES UN GRUPO AMINO ALQUENILO O ALQUILO C1-C7 DE CADENA RECTA O RAMIFICADA SATURADA O NO, SUSTITUIDA O NO; o A ES UN HETEROCICLO SATURADO O NO, SUSTITUIDO O NO DE 5, 6 o 7 MIEMBROS QUE CONTIENEN POR LO MENOS UN NITROGENO Y R4 ESTA UNIDO A ESTE NITROGENO. EL PROCESO PARA HACER COMPUESTOS DE FORMULA GENERAL (I) COMPRENDE : a) REACCIONAR UNA UREA 1-SUBSTITUIDA-4-OXOCICLICA CON UN REACTIVO DE CADENA DE CARBONO QUE CONTIENE POR LO MENOS DOS GRUPOS RESIDUALES EN PRESENCIA DE UNA BASE SUAVE Y UN DISOLVENTE PARA FORMAR UN ADUCTO QUE CONTIENE POR LO MENOS UN GRUPO RESIDUAL; b) CONDENSAR EL ADUCTO CON UNA AMINA PARA FORMAR UNA UREA 1,3-DISUBSTITUIDA-4-OXOCICLICA. EL COMPUESTO (I) PUEDE SER UTIL EN EL TRATAMIENTO DE VARIOS DESORDENES MEDICOS, COMO AGENTE ANTIFIBRILATORIO Y ANTIARRITMICO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8340698P | 1998-04-29 | 1998-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000439A1 true PE20000439A1 (es) | 2000-07-13 |
Family
ID=22178103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000354A PE20000439A1 (es) | 1998-04-29 | 1999-04-29 | Proceso para hacer ureas 1,3-disustituidas-4-oxociclicas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6420568B1 (es) |
| EP (1) | EP1075474B1 (es) |
| JP (1) | JP4514950B2 (es) |
| KR (1) | KR100400051B1 (es) |
| CN (1) | CN1298402A (es) |
| AR (1) | AR019120A1 (es) |
| AT (1) | ATE275563T1 (es) |
| AU (1) | AU747237B2 (es) |
| BR (1) | BR9910078A (es) |
| CA (1) | CA2330685A1 (es) |
| CO (1) | CO5050358A1 (es) |
| DE (1) | DE69920003T2 (es) |
| HU (1) | HUP0101356A3 (es) |
| ID (1) | ID27316A (es) |
| IL (1) | IL138405A (es) |
| MY (1) | MY133752A (es) |
| NO (1) | NO20005425D0 (es) |
| NZ (1) | NZ506773A (es) |
| PE (1) | PE20000439A1 (es) |
| PL (1) | PL198951B1 (es) |
| RU (1) | RU2194705C2 (es) |
| SK (1) | SK15832000A3 (es) |
| TR (1) | TR200003136T2 (es) |
| TW (1) | TW492965B (es) |
| WO (1) | WO1999055701A1 (es) |
| ZA (1) | ZA200004714B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9910074A (pt) * | 1998-04-29 | 2000-12-26 | Procter & Gamble | Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas |
| CN100443473C (zh) * | 2005-04-30 | 2008-12-17 | 中国药科大学 | 1-氨基-3-(氮杂环基烷基)-2,4-咪唑二酮的合成方法 |
| US20120178762A1 (en) | 2006-12-15 | 2012-07-12 | Warner Chilcott Company, Llc | Compositions of azimilide dihydrochloride |
| TW200840578A (en) * | 2006-12-15 | 2008-10-16 | Procter & Gamble | Compositions of azimilide dihydrochloride |
| US8123815B2 (en) | 2008-11-24 | 2012-02-28 | Biomet Manufacturing Corp. | Multiple bearing acetabular prosthesis |
| US8308810B2 (en) | 2009-07-14 | 2012-11-13 | Biomet Manufacturing Corp. | Multiple bearing acetabular prosthesis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1310190A (es) * | 1960-12-27 | 1963-03-06 | ||
| US3919231A (en) | 1974-06-17 | 1975-11-11 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3906010A (en) | 1974-06-17 | 1975-09-16 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3946049A (en) | 1975-04-03 | 1976-03-23 | Morton-Norwich Products, Inc. | 5-phenyl-2-furamidoximes |
| US4001222A (en) | 1975-10-14 | 1977-01-04 | Morton-Norwich Products, Inc. | 3-(Aminoacyl)-1-{[5-(substituted phenyl)furfurylidene]amino}hydantoins and process for their preparation thereof |
| JPS5726653A (en) | 1980-05-09 | 1982-02-12 | Ciba Geigy Ag | Substituted phenyl ether |
| IL82856A0 (en) | 1986-06-26 | 1987-12-20 | Norwich Eaton Pharma | Pharmaceutical compositions containing 2-(5-phenyl-2-furanyl)imidazoles and certain such novel compounds |
| US4882354A (en) | 1987-12-16 | 1989-11-21 | Norwich Eaton Pharmaceuticals, Inc. | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| JP3031973B2 (ja) * | 1990-08-16 | 2000-04-10 | 富士レビオ株式会社 | フェニトイン誘導体 |
| RU2221788C2 (ru) * | 1991-08-14 | 2004-01-20 | Проктер энд Гэмбл Фармасьютикалз | Оксоциклические соединения мочевины, фармацевтическая композиция, способ лечения |
| RU2125568C1 (ru) | 1991-08-14 | 1999-01-27 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Соединения циклического уретана или их фармацевтически приемлемые соли, способ лечения людей и других млекопитающих, страдающих сердечной аритмией и/или сердечной фибрилляцией, фармацевтическая композиция для лечения аритмии и фибрилляции |
| BR9910074A (pt) * | 1998-04-29 | 2000-12-26 | Procter & Gamble | Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas |
-
1999
- 1999-04-27 NZ NZ506773A patent/NZ506773A/xx not_active Application Discontinuation
- 1999-04-27 JP JP2000545861A patent/JP4514950B2/ja not_active Expired - Fee Related
- 1999-04-27 BR BR9910078-9A patent/BR9910078A/pt not_active IP Right Cessation
- 1999-04-27 PL PL343733A patent/PL198951B1/pl not_active IP Right Cessation
- 1999-04-27 ID IDW20002480A patent/ID27316A/id unknown
- 1999-04-27 RU RU2000129802/04A patent/RU2194705C2/ru not_active IP Right Cessation
- 1999-04-27 HU HU0101356A patent/HUP0101356A3/hu unknown
- 1999-04-27 TR TR2000/03136T patent/TR200003136T2/xx unknown
- 1999-04-27 IL IL13840599A patent/IL138405A/xx not_active IP Right Cessation
- 1999-04-27 CN CN99805365A patent/CN1298402A/zh active Pending
- 1999-04-27 DE DE69920003T patent/DE69920003T2/de not_active Expired - Lifetime
- 1999-04-27 SK SK1583-2000A patent/SK15832000A3/sk unknown
- 1999-04-27 AU AU37644/99A patent/AU747237B2/en not_active Ceased
- 1999-04-27 EP EP99920062A patent/EP1075474B1/en not_active Expired - Lifetime
- 1999-04-27 WO PCT/US1999/009093 patent/WO1999055701A1/en not_active Application Discontinuation
- 1999-04-27 KR KR10-2000-7011922A patent/KR100400051B1/ko not_active IP Right Cessation
- 1999-04-27 AT AT99920062T patent/ATE275563T1/de not_active IP Right Cessation
- 1999-04-27 CA CA002330685A patent/CA2330685A1/en not_active Abandoned
- 1999-04-27 US US09/674,228 patent/US6420568B1/en not_active Expired - Lifetime
- 1999-04-29 PE PE1999000354A patent/PE20000439A1/es not_active Application Discontinuation
- 1999-04-29 AR ARP990101995A patent/AR019120A1/es not_active Application Discontinuation
- 1999-04-29 CO CO99025955A patent/CO5050358A1/es unknown
- 1999-04-29 MY MYPI99001689A patent/MY133752A/en unknown
- 1999-07-28 TW TW088106940A patent/TW492965B/zh not_active IP Right Cessation
-
2000
- 2000-09-07 ZA ZA200004714A patent/ZA200004714B/en unknown
- 2000-10-27 NO NO20005425A patent/NO20005425D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ506773A (en) | 2004-03-26 |
| WO1999055701A1 (en) | 1999-11-04 |
| BR9910078A (pt) | 2000-12-26 |
| NO20005425L (no) | 2000-10-27 |
| DE69920003T2 (de) | 2005-09-15 |
| ATE275563T1 (de) | 2004-09-15 |
| SK15832000A3 (sk) | 2001-06-11 |
| CN1298402A (zh) | 2001-06-06 |
| EP1075474A1 (en) | 2001-02-14 |
| PL343733A1 (en) | 2001-09-10 |
| IL138405A (en) | 2005-03-20 |
| US6420568B1 (en) | 2002-07-16 |
| KR100400051B1 (ko) | 2003-09-29 |
| PL198951B1 (pl) | 2008-08-29 |
| ZA200004714B (en) | 2002-01-30 |
| AR019120A1 (es) | 2001-12-26 |
| HUP0101356A3 (en) | 2003-08-28 |
| AU747237B2 (en) | 2002-05-09 |
| DE69920003D1 (de) | 2004-10-14 |
| RU2194705C2 (ru) | 2002-12-20 |
| JP2002513022A (ja) | 2002-05-08 |
| MY133752A (en) | 2007-11-30 |
| JP4514950B2 (ja) | 2010-07-28 |
| ID27316A (id) | 2001-03-22 |
| HUP0101356A2 (hu) | 2002-05-29 |
| CA2330685A1 (en) | 1999-11-04 |
| KR20010043053A (ko) | 2001-05-25 |
| TR200003136T2 (tr) | 2001-03-21 |
| IL138405A0 (en) | 2001-10-31 |
| EP1075474B1 (en) | 2004-09-08 |
| NO20005425D0 (no) | 2000-10-27 |
| TW492965B (en) | 2002-07-01 |
| CO5050358A1 (es) | 2001-06-27 |
| AU3764499A (en) | 1999-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |