PE120699A1 - Procedimiento e intermedios utiles para preparar antifolatos - Google Patents

Procedimiento e intermedios utiles para preparar antifolatos

Info

Publication number
PE120699A1
PE120699A1 PE1998000912A PE00091298A PE120699A1 PE 120699 A1 PE120699 A1 PE 120699A1 PE 1998000912 A PE1998000912 A PE 1998000912A PE 00091298 A PE00091298 A PE 00091298A PE 120699 A1 PE120699 A1 PE 120699A1
Authority
PE
Peru
Prior art keywords
procedure
antifolates
prepare
useful intermediates
useful
Prior art date
Application number
PE1998000912A
Other languages
English (en)
Inventor
Brian James Slattery
Charles Jackson Barnett
Douglas Kjell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE120699A1 publication Critical patent/PE120699A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA IV; DONDE M ES UN CATION METALICO; n ES 1 o 2; R2 ES NHCH(CO2R3)CH2CH2CO2R3 o OR3; R3 ES UN GRUPO PROTECTOR DE CARBOXILO; X ES UN ENLACE o ALQUIL-DIILO C1-C4. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE LA REACCION DEL COMPUESTO III CON M+(HSO3-)n; m ES CATION METALICO; n ES 1 o 2 EN UN DISOLVENTE COMO ACETONITRILO. EL COMPUESTO III ES UN INTERMEDIO UTIL EN LA SINTESIS DE COMPUESTOS ANTIFOLATO VALIOSOS; QUE PUEDEN SER UTILES PARA EL TRATAMIENTO DEL CANCER
PE1998000912A 1997-09-26 1998-09-24 Procedimiento e intermedios utiles para preparar antifolatos PE120699A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93838597A 1997-09-26 1997-09-26

Publications (1)

Publication Number Publication Date
PE120699A1 true PE120699A1 (es) 1999-12-01

Family

ID=25471339

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000912A PE120699A1 (es) 1997-09-26 1998-09-24 Procedimiento e intermedios utiles para preparar antifolatos

Country Status (15)

Country Link
EP (1) EP0905128B1 (es)
AR (1) AR017152A1 (es)
AT (1) ATE213494T1 (es)
CO (1) CO4970706A1 (es)
CY (1) CY2005003I2 (es)
DE (1) DE69803909T2 (es)
DK (1) DK0905128T3 (es)
ES (1) ES2169481T3 (es)
HK (1) HK1020437A1 (es)
MY (1) MY116775A (es)
PE (1) PE120699A1 (es)
PT (1) PT905128E (es)
SI (1) SI0905128T1 (es)
TW (1) TW442457B (es)
ZA (1) ZA987550B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL208061B1 (pl) * 2000-02-25 2011-03-31 Lilly Co Eli Postać krystaliczna heptahydratu soli disodowej kwasu N-[4-[2-(2-amino-4,7-dihydro-4-okso-3H-pirolo [2,3-d]-pirymidyn-5-ylo) etylo] benzoilo]-L-glutaminowego i jej zastosowanie
CN100395246C (zh) * 2005-06-15 2008-06-18 江苏豪森药业股份有限公司 用于制造叶酸拮抗剂及其中间体的方法
CN101591247B (zh) * 2008-05-30 2012-09-05 上海希迪制药有限公司 合成4-(4-甲酯基苯基)丁醛的方法
WO2010028105A2 (en) * 2008-09-08 2010-03-11 Dr. Reddy's Laboratories Ltd. Amorphous pemetrexed disodium
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
CN103459392B (zh) * 2011-03-25 2016-08-17 台湾神隆股份有限公司 一种制备培美曲塞盐的方法
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
KR101578093B1 (ko) * 2013-09-05 2015-12-16 주식회사 삼양바이오팜 고순도 페메트렉세드 제조를 위한 향상된 중간체 제조 방법 및 이를 사용하여 고순도 페메트렉세드를 제조하는 방법
CN107628947B (zh) * 2017-09-14 2020-07-28 浙江工业大学 一种培美曲塞二钠关键中间体的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines

Also Published As

Publication number Publication date
DK0905128T3 (da) 2002-03-25
AR017152A1 (es) 2001-08-22
TW442457B (en) 2001-06-23
CY2005003I1 (el) 2011-02-02
ATE213494T1 (de) 2002-03-15
CO4970706A1 (es) 2000-11-07
EP0905128A1 (en) 1999-03-31
DE69803909D1 (de) 2002-03-28
CY2005003I2 (el) 2011-02-02
SI0905128T1 (en) 2002-08-31
DE69803909T2 (de) 2002-10-10
HK1020437A1 (en) 2000-04-20
ES2169481T3 (es) 2002-07-01
PT905128E (pt) 2002-07-31
EP0905128B1 (en) 2002-02-20
ZA987550B (en) 2000-02-21
MY116775A (en) 2004-03-31

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed