AR007200A1 - Derivados de acido n,n'-di(2-hidroxibencil)etilendiamina-n,n'-diacetico, su aplicacion, su empleo, procedimiento para elaborarlos y preparacionesfarmaceuticas que contienen a dichos derivados. - Google Patents

Derivados de acido n,n'-di(2-hidroxibencil)etilendiamina-n,n'-diacetico, su aplicacion, su empleo, procedimiento para elaborarlos y preparacionesfarmaceuticas que contienen a dichos derivados.

Info

Publication number
AR007200A1
AR007200A1 ARP970102121A ARP970102121A AR007200A1 AR 007200 A1 AR007200 A1 AR 007200A1 AR P970102121 A ARP970102121 A AR P970102121A AR P970102121 A ARP970102121 A AR P970102121A AR 007200 A1 AR007200 A1 AR 007200A1
Authority
AR
Argentina
Prior art keywords
derivatives
lower alkyl
hydrogen
procedure
application
Prior art date
Application number
ARP970102121A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR007200A1 publication Critical patent/AR007200A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen derivados de ácido N,N-di(2-hidroxibencil)etilendiamina-N,N- diacético de la fórmula (I), en la cual R1 es hidrógeno o acilo; R2 es OR3 oNR4R5; R3 es alquilo inferior, cicloalquilo inferior, alcoxi inferior-alquilo inferior, alcoxi inferior-carbonilo-alquilo inferior, o bien alcoxicarboxiinferior-alquilo inferior, substituidos o insustituidos; R4 y R5, independientemente entre ellos, son hidrógeno, o bien alquilo inferiorinsustituido o sustituido; R6 y R7 independientemente entre ellos son hidrógeno, halógeno, alquilo inferior o alcoxi inferior; R8 y R9individualmente son hidrógeno, o en conjunto n-butileno; y sales de los mismos. Los compuestos acusan valiosas propiedades farmacéuticas y son particularmenteactivos como quelantes de hierro. Pueden ser aprovechados para el tratamiento de un exceso de hierro en el cuerpo de seres de sangre caliente. Además sedescribe la aplicación y el empleo de dichos derivados, el procedimiento para obtenerlosy preparaciones farmacéuticas que los contienen.
ARP970102121A 1996-05-21 1997-05-20 Derivados de acido n,n'-di(2-hidroxibencil)etilendiamina-n,n'-diacetico, su aplicacion, su empleo, procedimiento para elaborarlos y preparacionesfarmaceuticas que contienen a dichos derivados. AR007200A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH127296 1996-05-21

Publications (1)

Publication Number Publication Date
AR007200A1 true AR007200A1 (es) 1999-10-13

Family

ID=4206536

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102121A AR007200A1 (es) 1996-05-21 1997-05-20 Derivados de acido n,n'-di(2-hidroxibencil)etilendiamina-n,n'-diacetico, su aplicacion, su empleo, procedimiento para elaborarlos y preparacionesfarmaceuticas que contienen a dichos derivados.

Country Status (3)

Country Link
AR (1) AR007200A1 (es)
AU (1) AU2958397A (es)
WO (1) WO1997044313A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE285232T1 (de) 1998-02-04 2005-01-15 Univ Florida N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie
CA2385551A1 (en) 1999-10-01 2001-04-12 Dmi Biosciences, Inc. Metal-binding compounds and uses therefor
US6646157B2 (en) 1999-12-21 2003-11-11 Geltex Pharmaceuticals, Inc. Method for making HBED
WO2015191343A1 (en) 2014-06-12 2015-12-17 The Procter & Gamble Company System and methods of detecting and demonstrating ultraviolet damage to hair via evaluation of protein fragments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632637A (en) * 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
US4528196A (en) * 1981-02-23 1985-07-09 The United States Of America As Represented By The Department Of Health And Human Services Chelating agents for the treatment of iron overload
EP0734374A1 (en) * 1993-12-16 1996-10-02 Novartis AG N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid derivatives as chelating agents

Also Published As

Publication number Publication date
AU2958397A (en) 1997-12-09
WO1997044313A1 (en) 1997-11-27

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