AR007200A1 - DERIVATIVES OF ACID N, N'-DI (2-HIDROXIBENCIL) ETILENDIAMINA-N, N'-DIACETIC, ITS APPLICATION, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM AND PREPARATIONS FOR THESE DERIVATIVES. - Google Patents

DERIVATIVES OF ACID N, N'-DI (2-HIDROXIBENCIL) ETILENDIAMINA-N, N'-DIACETIC, ITS APPLICATION, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM AND PREPARATIONS FOR THESE DERIVATIVES.

Info

Publication number
AR007200A1
AR007200A1 ARP970102121A ARP970102121A AR007200A1 AR 007200 A1 AR007200 A1 AR 007200A1 AR P970102121 A ARP970102121 A AR P970102121A AR P970102121 A ARP970102121 A AR P970102121A AR 007200 A1 AR007200 A1 AR 007200A1
Authority
AR
Argentina
Prior art keywords
derivatives
lower alkyl
hydrogen
procedure
application
Prior art date
Application number
ARP970102121A
Other languages
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR007200A1 publication Critical patent/AR007200A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

Se describen derivados de ácido N,N-di(2-hidroxibencil)etilendiamina-N,N- diacético de la fórmula (I), en la cual R1 es hidrógeno o acilo; R2 es OR3 oNR4R5; R3 es alquilo inferior, cicloalquilo inferior, alcoxi inferior-alquilo inferior, alcoxi inferior-carbonilo-alquilo inferior, o bien alcoxicarboxiinferior-alquilo inferior, substituidos o insustituidos; R4 y R5, independientemente entre ellos, son hidrógeno, o bien alquilo inferiorinsustituido o sustituido; R6 y R7 independientemente entre ellos son hidrógeno, halógeno, alquilo inferior o alcoxi inferior; R8 y R9individualmente son hidrógeno, o en conjunto n-butileno; y sales de los mismos. Los compuestos acusan valiosas propiedades farmacéuticas y son particularmenteactivos como quelantes de hierro. Pueden ser aprovechados para el tratamiento de un exceso de hierro en el cuerpo de seres de sangre caliente. Además sedescribe la aplicación y el empleo de dichos derivados, el procedimiento para obtenerlosy preparaciones farmacéuticas que los contienen.Derivatives of N, N-di (2-hydroxybenzyl) ethylenediamine-N, N-diacetic acid of the formula (I) are described, in which R1 is hydrogen or acyl; R2 is OR3 or NR4R5; R3 is lower alkyl, lower cycloalkyl, lower alkoxy-lower alkyl, lower alkoxy-carbonyl-lower alkyl, or substituted or unsubstituted lower alkoxycarboxy-lower alkyl; R4 and R5, independently of one another, are hydrogen, or substituted or unsubstituted lower alkyl; R6 and R7 independently of one another are hydrogen, halogen, lower alkyl or lower alkoxy; R8 and R9 individually are hydrogen, or together n-butylene; and you leave them. The compounds have valuable pharmaceutical properties and are particularly active as iron chelators. They can be used to treat excess iron in the body of warm-blooded beings. In addition, the application and use of said derivatives, the procedure to obtain them and pharmaceutical preparations containing them are described.

ARP970102121A 1996-05-21 1997-05-20 DERIVATIVES OF ACID N, N'-DI (2-HIDROXIBENCIL) ETILENDIAMINA-N, N'-DIACETIC, ITS APPLICATION, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM AND PREPARATIONS FOR THESE DERIVATIVES. AR007200A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH127296 1996-05-21

Publications (1)

Publication Number Publication Date
AR007200A1 true AR007200A1 (en) 1999-10-13

Family

ID=4206536

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102121A AR007200A1 (en) 1996-05-21 1997-05-20 DERIVATIVES OF ACID N, N'-DI (2-HIDROXIBENCIL) ETILENDIAMINA-N, N'-DIACETIC, ITS APPLICATION, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM AND PREPARATIONS FOR THESE DERIVATIVES.

Country Status (3)

Country Link
AR (1) AR007200A1 (en)
AU (1) AU2958397A (en)
WO (1) WO1997044313A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200002256T2 (en) 1998-02-04 2001-03-21 University Of Florida Research Foundation, Inc. Pharmaceuticals containing N, N '-BIS (2-Hydroxybenzyl) ethylenediamine-N, N'diacetic acid in the treatment of iron chelating.
KR20110049875A (en) 1999-10-01 2011-05-12 디엠아이 바이오사이언시스, 인크 Metal-binding compounds and uses therefor
WO2001045696A1 (en) * 1999-12-21 2001-06-28 University Of Florida Research Foundation, Inc. N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid in iron chelating therapy
US20150362507A1 (en) 2014-06-12 2015-12-17 The Procter & Gamble Company System and Methods of Detecting and Demonstrating Ultraviolet Damage to Hair Via Evaluation of Protein Fragments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632637A (en) * 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
US4528196A (en) * 1981-02-23 1985-07-09 The United States Of America As Represented By The Department Of Health And Human Services Chelating agents for the treatment of iron overload
AU1033495A (en) * 1993-12-16 1995-07-03 Ciba-Geigy Ag N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid derivatives as chelating agents

Also Published As

Publication number Publication date
WO1997044313A1 (en) 1997-11-27
AU2958397A (en) 1997-12-09

Similar Documents

Publication Publication Date Title
IL129068A0 (en) Sulfinic acid derivatives and their preparation and use
BR9810554A (en) Aroil piperazines to regulate sexual activity
TR200000481T2 (en) Derivatives of N-Alkoxyphenylalanine.
TR199800436A2 (en) Use of pyrimidine derivatives for cancer prevention.
UY26256A1 (en) CARBOXYLIC ACID AMIDES, MEDICINES CONTAINING THESE COMPOUNDS, THEIR USE AND THEIR PREPARATION
LV10441A (en) The use of pyrimidine-4,6-dicarboxylic diamides for their application and therapeutic agents containing these compounds
ATE111342T1 (en) DYE FOR KERATINE FIBERS.
NZ220835A (en) 5-alkoxy-2,4-diamino-alkylbenzenes and their use in hair dyeing agents
DE69806962T2 (en) FSNMU as an anti-inflammatory agent in the surface tissues of mammals
ES2135769T3 (en) DERIVATIVES OF ISOTIOUREA AS INHIBITORS OF NO-SINTASA.
FR2684296B1 (en) PROCESS FOR DYEING KERATINIC FIBERS WITH AN ACID PH ALCOXYMETAPHENYLENEDIAMINE AND COMPOSITIONS IMPLEMENTED.
ES2046384T3 (en) PREPARATION OF DYE FOR THE HAIR.
AR007200A1 (en) DERIVATIVES OF ACID N, N'-DI (2-HIDROXIBENCIL) ETILENDIAMINA-N, N'-DIACETIC, ITS APPLICATION, ITS EMPLOYMENT, PROCEDURE TO PREPARE THEM AND PREPARATIONS FOR THESE DERIVATIVES.
FI872576A0 (en) PEPTIDER MED INVERKAN PAO DIURES OCH NATRIURES, FOERFARANDE FOER FRAMSTAELLNING AV DESSA OCH MEDEL INNEHAOLLANDE DESSA OCH DERAS ANVAENDNING.
ES2059688T3 (en) DERIVATIVES OF AMINO ACID INHIBITORS OF ENZYMES, PROCEDURE FOR THEIR PREPARATION, AGENTS THAT CONTAIN THEM AND THEIR USE.
ES2176723T3 (en) COMPOSITIONS FOR THE DYE OF THE QUERATINIC FIBERS CONTAINING PIRAZOLIN-3,5-DIONA, ITS USE AS COPULATORS FOR THE DYE AND DYE METHOD.
BE901090A (en) TINCTORIAL COMPOSITION FOR THE DIRECT COLORING OF KERATINIC FIBERS, CONTAINING AT LEAST ONE NITRO-2 PARAPHENYLENEDIAMINE N-SUBSTITUTED COSOLUBILIZED.
FR2430232A1 (en) NOVEL ARYLAMINOBENZOIC ACIDS USEFUL IN PARTICULAR AS HYPOGLYCEMATING AGENTS
DE60000234T2 (en) Indole compounds, their use in dyeing and making up keratin fibers, compositions containing them and dyeing processes
MX9301627A (en) AGENT TO BE USED AS AN ANTI-IRRITANT AND CONTAINING COMPOSITION.
BR8906421A (en) PROCESS FOR THE PREPARATION OF PYRIDINE-3-PEROXICARBOXYLIC ACID MONOPERSULPHATE
BR9906975A (en) Compound, use of it, pharmaceutical composition, and process to stimulate the release of growth hormone by the pituitary of a mammal
MX9303392A (en) DERIVATIVES OF IMIDAZO BENZOXAZIN-1-ONA SUBSTITUTED AND PROCESS FOR ITS PREPARATION.
DE59608649D1 (en) OXIDATION DYE FOR DYING KERATINE FIBERS CONTAINING A SPECIAL COMBINATION OF DEVELOPER COMPONENTS AND ALKALIZING AGENTS
ZA902543B (en) Nitroaniline dyes with a cyano substituent group