ATE285232T1 - N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie - Google Patents

N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie

Info

Publication number
ATE285232T1
ATE285232T1 AT99905716T AT99905716T ATE285232T1 AT E285232 T1 ATE285232 T1 AT E285232T1 AT 99905716 T AT99905716 T AT 99905716T AT 99905716 T AT99905716 T AT 99905716T AT E285232 T1 ATE285232 T1 AT E285232T1
Authority
AT
Austria
Prior art keywords
hydroxybenzyl
ethylenediamine
bis
diacetic acid
sodium salts
Prior art date
Application number
AT99905716T
Other languages
English (en)
Inventor
Raymond J Bergeron Jr
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Application granted granted Critical
Publication of ATE285232T1 publication Critical patent/ATE285232T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99905716T 1998-02-04 1999-02-03 N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie ATE285232T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7360398P 1998-02-04 1998-02-04
PCT/US1999/002388 WO1999039706A1 (en) 1998-02-04 1999-02-03 Pharmaceuticals comprising n,n'-bis(2- hydroxybenzyl) ethylenediamine-n, n'-diacetic acid for iron chelating therapy

Publications (1)

Publication Number Publication Date
ATE285232T1 true ATE285232T1 (de) 2005-01-15

Family

ID=22114691

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99905716T ATE285232T1 (de) 1998-02-04 1999-02-03 N,n'-bis(2-hydroxybenzyl)ethylendiamin-n,n'- diessigsäure und natriumsalze davon zur eisenchelatierungstherapie

Country Status (13)

Country Link
US (2) US6242492B1 (de)
EP (1) EP1052985B1 (de)
JP (1) JP2002502816A (de)
CN (1) CN1227006C (de)
AT (1) ATE285232T1 (de)
AU (1) AU752383B2 (de)
CA (1) CA2319255C (de)
DE (1) DE69922787T2 (de)
ES (1) ES2235461T3 (de)
NZ (1) NZ506528A (de)
PT (1) PT1052985E (de)
TR (1) TR200002256T2 (de)
WO (1) WO1999039706A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7232830B2 (en) * 1998-06-26 2007-06-19 Elaine A Delack Method for treatment of neurodegenerative diseases and effects of aging
KR20100075503A (ko) 1999-10-01 2010-07-02 디엠아이 바이오사이언시스, 인크 금속 결합 화합물 및 그의 용도
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
AU2293101A (en) 1999-12-21 2001-07-03 Geltex Pharmaceuticals, Inc. Method for making hbed
US7160855B2 (en) * 2002-03-14 2007-01-09 Children's Hospital & Research Center At Oakland Enhancement of iron chelation therapy
ES2732625T3 (es) * 2005-04-04 2019-11-25 Univ Florida Análogos de poliéter de desferritiocina
TWI488624B (zh) 2008-09-22 2015-06-21 Nat University Corp Asahikawa Medical College 鐵螯合劑、其製造方法及鐵離子之定量、捕捉方法
WO2010133907A1 (en) * 2009-05-18 2010-11-25 Carlo Ghisalberti Hexadentate chelators in inflammatory bowel disease
US20110077417A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for Hydroxylated Contrast Enhancement Agents
US20110077396A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US8378134B2 (en) * 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
EP2664333B1 (de) 2011-01-14 2016-10-12 Disease Adsorption System Technologies Co., Ltd. Polymere eisenchelatbildner
WO2012104204A1 (en) 2011-01-31 2012-08-09 Vifor (International) Ag Iron-carbohydrate complex compounds for the intravenous therapy of malaria
CN104706631A (zh) * 2013-12-14 2015-06-17 于莹莹 一种铁螯合剂作为制备抗癌药物的应用
PL3313814T3 (pl) 2015-06-25 2020-07-13 Akzo Nobel Chemicals International B.V. Sposób otrzymywania fenolowych związków kwasu etylenodiaminodioctowego
EP3313813B1 (de) 2015-06-25 2019-04-10 Akzo Nobel Chemicals International B.V. Verfahren zur herstellung von phenolischen ethylendiamindiessigsäureverbindungen

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US3005848A (en) 1957-09-09 1961-10-24 Geigy Chem Corp Ethylenediamine derivatives containing aromatic rings
US3758540A (en) 1968-02-13 1973-09-11 A Martell Ferric chelates of n-(2-hydroxybenzyl) substituted aminopoly carboxylic acids
BE786946A (fr) 1971-07-29 1973-01-29 Ciba Geigy Chelates pour combattre des symptomes de carences en metaux dans des systemes biologiques
GB1439048A (en) 1973-09-11 1976-06-09 Ciba Geigy Ag Metal complexes of bis-azomethines and processes for their manufacture
FR2267308B1 (de) 1974-04-12 1976-10-08 Protex Manuf Prod Chimiq
CH602857A5 (de) 1976-12-10 1978-08-15 Ciba Geigy Ag
US4130582A (en) 1977-04-19 1978-12-19 Ciba-Geigy Corporation Preparation of phenolic ethylenediaminepolycarboxylic acids
US4352751A (en) 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4528196A (en) * 1981-02-23 1985-07-09 The United States Of America As Represented By The Department Of Health And Human Services Chelating agents for the treatment of iron overload
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4454106A (en) 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4909257A (en) 1986-05-01 1990-03-20 The Regents Of The University Of California Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
IE980696A1 (en) 1988-10-31 2000-12-13 Dow Chemical Co Chelants processing ortho ligating functionality and complexes thereof
US5376154A (en) 1991-05-13 1994-12-27 The Lubrizol Corporation Low-sulfur diesel fuels containing organometallic complexes
US5840739A (en) * 1992-11-16 1998-11-24 University Of Florida Research Foundation, Inc. Thiazoline acid derivatives
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
HUT74457A (en) * 1993-12-16 1996-12-30 Ciba Geigy Ag N,n`-bis(2-hydroxybenzyl)ethylenediamine-n,n`-diacetic acid derivatives, process for preparing them and pharmaceutical compns. contg. them
US5539138A (en) 1994-07-28 1996-07-23 Merck Frosst Canada, Inc. High affinity chelates containing isothiocyanate groups, useful for coupling with peptides and proteins
AR007200A1 (es) 1996-05-21 1999-10-13 Novartis Ag Derivados de acido n,n'-di(2-hidroxibencil)etilendiamina-n,n'-diacetico, su aplicacion, su empleo, procedimiento para elaborarlos y preparacionesfarmaceuticas que contienen a dichos derivados.

Also Published As

Publication number Publication date
AU2581499A (en) 1999-08-23
CN1227006C (zh) 2005-11-16
WO1999039706A1 (en) 1999-08-12
US6531510B1 (en) 2003-03-11
TR200002256T2 (tr) 2001-03-21
US6242492B1 (en) 2001-06-05
EP1052985B1 (de) 2004-12-22
EP1052985A1 (de) 2000-11-22
JP2002502816A (ja) 2002-01-29
NZ506528A (en) 2002-11-26
AU752383B2 (en) 2002-09-19
WO1999039706A9 (en) 2000-09-21
ES2235461T3 (es) 2005-07-01
CA2319255A1 (en) 1999-08-12
DE69922787T2 (de) 2005-12-15
CN1290163A (zh) 2001-04-04
PT1052985E (pt) 2005-04-29
DE69922787D1 (de) 2005-01-27
CA2319255C (en) 2010-01-26

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